Alzheimer's disease causes: Difference between revisions
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* AKAP9 gene: | * AKAP9 gene: | ||
** In African-Americans only | ** In African-Americans only | ||
| colspan="1" rowspan="1" |15%-25% | | colspan="1" rowspan="1" |15%-25% of familial cases | ||
|- | |- | ||
| colspan="1" rowspan="1" | | | colspan="1" rowspan="1" | | ||
Line 52: | Line 52: | ||
** Proportion: 10-15 % of early onset AD cases | ** Proportion: 10-15 % of early onset AD cases | ||
** Protein: Amyloid precursor protein (APP) | ** Protein: Amyloid precursor protein (APP) | ||
| colspan="1" rowspan="1" |<2% | | colspan="1" rowspan="1" |<2% of familia cases | ||
|- | |- | ||
| colspan="1" rowspan="1" |'''Unknown (includes genetic/environment interactions)''' | | colspan="1" rowspan="1" |'''Unknown (includes genetic/environment interactions)''' |
Revision as of 23:50, 17 September 2017
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
Causes
The following are the causes of Alzheimer's dementia (AD):[1][2][3][4][5]
Cause | Specific characteristics | Percentage of cases |
---|---|---|
Chromosomal (Down syndrome) |
|
<1% |
All familial | ~25% | |
|
|
15%-25% of familial cases |
|
|
<2% of familia cases |
Unknown (includes genetic/environment interactions) |
|
~75% |
References
- ↑ "Alzheimer Disease Overview - GeneReviews® - NCBI Bookshelf".
- ↑ Brickell KL, Steinbart EJ, Rumbaugh M, Payami H, Schellenberg GD, Van Deerlin V, Yuan W, Bird TD (2006). "Early-onset Alzheimer disease in families with late-onset Alzheimer disease: a potential important subtype of familial Alzheimer disease". Arch. Neurol. 63 (9): 1307–11. doi:10.1001/archneur.63.9.1307. PMID 16966510.
- ↑ Campion D, Dumanchin C, Hannequin D, Dubois B, Belliard S, Puel M, Thomas-Anterion C, Michon A, Martin C, Charbonnier F, Raux G, Camuzat A, Penet C, Mesnage V, Martinez M, Clerget-Darpoux F, Brice A, Frebourg T (1999). "Early-onset autosomal dominant Alzheimer disease: prevalence, genetic heterogeneity, and mutation spectrum". Am. J. Hum. Genet. 65 (3): 664–70. doi:10.1086/302553. PMC 1377972. PMID 10441572.
- ↑ Munoz DG, Feldman H (2000). "Causes of Alzheimer's disease". CMAJ. 162 (1): 65–72. PMC 1232234. PMID 11216203.
- ↑ Hölscher C (1998). "Possible causes of Alzheimer's disease: amyloid fragments, free radicals, and calcium homeostasis". Neurobiol. Dis. 5 (3): 129–41. doi:10.1006/nbdi.1998.0193. PMID 9848086.