Adult T-cell leukemia differential diagnosis: Difference between revisions

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{{Adult T-cell leukemia}}
[[Image:Home_logo1.png|right|250px|link=https://www.wikidoc.org/index.php/Adult_T-cell_leukemia]]
{{CMG}}; {{AE}} {{HL}}; {{GRR}} {{Nat}}


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==Overview==
Adult T-cell leukemia must be differentiated from other diseases that cause [[weight loss]],  [[night sweats]], [[hepatosplenomegaly]], and palpable [[lymph node]]s, such as [[hairy cell leukaemia]], prolymphocytic leukaemia, [[follicular lymphoma]], and [[mantle cell lymphoma]].
 
==Differentiating Adult T-cell Leukemia from other Diseases==
* Adult T-cell leukemia must be differentiated from other diseases that cause [[weight loss]], [[night sweats]], [[hepatosplenomegaly]], and palpable [[lymph node]]s, such as [[hairy cell leukaemia]], prolymphocytic leukaemia, [[follicular lymphoma]], and [[mantle cell lymphoma]].<ref name="wiki">Adult T-cell leukemia/lymphoma. Wikipedia (2015) https://en.wikipedia.org/wiki/Adult_T-cell_leukemia/lymphoma Accessed on November, 3 2015</ref><ref name="pmid20198459">{{cite journal |vauthors=Chuang SS, Ichinohasama R, Chu JS, Ohshima K |title=Differential diagnosis of angioimmunoblastic T-cell lymphoma with seropositivity for anti-HTLV antibody from adult T-cell leukemia/lymphoma |journal=Int. J. Hematol. |volume=91 |issue=4 |pages=687–91 |date=May 2010 |pmid=20198459 |doi=10.1007/s12185-010-0540-x |url=}}</ref><ref name="H">Hoffbrand V, Moss P. Essential Haematology. John Wiley & Sons; 2011</ref><ref name="pmid29685460">{{cite journal |vauthors=Rodríguez-Zúñiga MJM, Cortez-Franco F, Qujiano-Gomero E |title=Adult T-Cell Leukemia/Lymphoma. Review of the Literature |journal=Actas Dermosifiliogr |volume=109 |issue=5 |pages=399–407 |date=June 2018 |pmid=29685460 |doi=10.1016/j.ad.2017.08.014 |url=}}</ref>
* Based on the expression of cell surface markers, the table below differentiates adult T-cell leukemia from other diseases that cause similar clinical presentations:
{| style="border: 0px; font-size: 90%; margin: 3px; width: 1000px"
 
|+
! style="background: #4479BA; width: 600px;" | {{fontcolor|#FFF|'''Differential Diagnosis'''}}
! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|'''Surface Immunoglobulin'''}}
! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|'''CD5'''}}
! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|'''CD22/FMC7'''}}
! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|'''CD23'''}}
! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|'''CD79b'''}}
! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|'''CD103'''}}
 
|-
 
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
'''Chronic lymphocytic leukemia'''
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
Weakly positive
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
Positive
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
Negative
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
Positive
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
Negative
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
Positive/Negative
 
|-
 
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
'''Prolymphocytic leukemia'''
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
Strongly positive
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
Negative
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
Positive
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
Negative
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
Positive
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
Negative
 
|-
 
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
'''Hairy cell leukemia'''
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
Strongly positive
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
Negative
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
Positive
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
Negative
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
Positive/Negative
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
Positive
 
|-
 
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
'''Mantle cell lymphoma'''
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
Positive
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
Positive
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
Strongly positive
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
Negative
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
Strongly positive
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
Negative
 
|-
 
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
'''Follicular lymphoma'''
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
Strongly positive
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
Negative
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
Positive
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
Negative
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
Strongly positive
| style="padding: 5px 5px; background: #F5F5F5;" align="center" |
Negative
|}
<br>
* Adult T-cell leukemia must also be differentiated from other causes of [[fever]], [[hepatosplenomegaly]], and [[lymph node]] swelling such as:
:* [[Splenic marginal zone lymphoma]]
:* Nodal marginal zone [[lymphoma]]
:* [[Lymphoplasmacytic lymphoma]]
:* [[Sézary syndrome]]


==References==
==References==
{{Reflist|2}}
{{Reflist|2}}


{{WH}}
[[Category:Medicine]]
{{WS}}
 
[[Category:Needs content]]
[[Category:Disease]]
[[Category:Pathology]]
[[Category:Hematology]]
[[Category:Hematology]]
[[Category:Immunology]]
[[Category:Infectious disease]]
[[Category:Oncology]]
[[Category:Up-To-Date]]

Latest revision as of 20:18, 29 July 2020

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]; Grammar Reviewer: Natalie Harpenau, B.S.[3]

Overview

Adult T-cell leukemia must be differentiated from other diseases that cause weight loss, night sweats, hepatosplenomegaly, and palpable lymph nodes, such as hairy cell leukaemia, prolymphocytic leukaemia, follicular lymphoma, and mantle cell lymphoma.

Differentiating Adult T-cell Leukemia from other Diseases

Differential Diagnosis Surface Immunoglobulin CD5 CD22/FMC7 CD23 CD79b CD103

Chronic lymphocytic leukemia

Weakly positive

Positive

Negative

Positive

Negative

Positive/Negative

Prolymphocytic leukemia

Strongly positive

Negative

Positive

Negative

Positive

Negative

Hairy cell leukemia

Strongly positive

Negative

Positive

Negative

Positive/Negative

Positive

Mantle cell lymphoma

Positive

Positive

Strongly positive

Negative

Strongly positive

Negative

Follicular lymphoma

Strongly positive

Negative

Positive

Negative

Strongly positive

Negative


References

  1. ↑ Adult T-cell leukemia/lymphoma. Wikipedia (2015) https://en.wikipedia.org/wiki/Adult_T-cell_leukemia/lymphoma Accessed on November, 3 2015
  2. ↑ Chuang SS, Ichinohasama R, Chu JS, Ohshima K (May 2010). "Differential diagnosis of angioimmunoblastic T-cell lymphoma with seropositivity for anti-HTLV antibody from adult T-cell leukemia/lymphoma". Int. J. Hematol. 91 (4): 687–91. doi:10.1007/s12185-010-0540-x. PMID 20198459.
  3. ↑ Hoffbrand V, Moss P. Essential Haematology. John Wiley & Sons; 2011
  4. ↑ Rodríguez-Zúñiga M, Cortez-Franco F, Qujiano-Gomero E (June 2018). "Adult T-Cell Leukemia/Lymphoma. Review of the Literature". Actas Dermosifiliogr. 109 (5): 399–407. doi:10.1016/j.ad.2017.08.014. PMID 29685460. Vancouver style error: initials (help)
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