Acinic cell carcinoma pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ramyar Ghandriz MD[2]
Overview
Pathophysiology
Genetics
- The development of acinic cell carcinoma is the result of multiple genetic mutations that suggest association of tumor suppression genes such as[1][2]:
- chromosome 5q
- chromosome 6p
- chromosome 17p
- Deletions of chromosome 6q
- Loss of Y
- Trisomy 21
- Molucular syudies suggest that retinoblastoma pathway also can be involved with acinic cell carcinoma.[3]
Associated Conditions
Gross Pathology
- On gross pathology, acinic cell carcinoma usually presents as a solitary, encapsulated, soft tumor of gray-whit appearance.[4][5]
- In case of recurrent lesions, the tumor is often lobulated without capsule with necrosis area.
Microscopic Pathology
- On microscopic histopathological acinar cell carcinoma is defined by serous acinar cell differentiation.[8][9][10][11]
- several growth patterns are recognized:
- Non-specific glandular
- Solid-lobular
- Microcystic
- Papillary-cystic
- Follicular
- several cell types and their own differentiation are recognized:
- Acinar cells
- Intercalated ductal cells
- Vacuolated cells
- Clear cells
References
- ↑ El-Naggar, Adel K; Abdul-Karim, Fadi W; Hurr, Kenneth; Callender, David; Luna, Mario A; Batsakis, John G (1998). "Genetic Alterations in Acinic Cell Carcinoma of the Parotid Gland Determined by Microsatellite Analysis". Cancer Genetics and Cytogenetics. 102 (1): 19–24. doi:10.1016/S0165-4608(97)00273-2. ISSN 0165-4608.
- ↑ Sandros J, Mark J, Happonen RP, Stenman G (1988). "Specificity of 6q- markers and other recurrent deviations in human malignant salivary gland tumors". Anticancer Res. 8 (4): 637–43. PMID 3178153.
- ↑ Liu, T; Zhu, E; Wang, L; Okada, T; Yamaguchi, A; Okada, N (2005). "Abnormal expression of Rb pathway–related proteins in salivary gland acinic cell carcinoma". Human Pathology. 36 (9): 962–970. doi:10.1016/j.humpath.2005.06.014. ISSN 0046-8177.
- ↑ "Tumors of the Salivary Glands, Atlas of Tumor Pathology: Third Series, Fascicle 17 G. L. Ellis and P. L. Auclair. Armed Forces Institute of Pathology, Washington D.C. ISBN: 1 881041 26 3 (Printed). 1996. Price: $69.00. ISBN: 1 881041 41 7 (CD-ROM). 1998. Price: $65.00". The Journal of Pathology. 192 (4): 564–565. 2000. doi:10.1002/1096-9896(200012)192:4<564::AID-PATH737>3.0.CO;2-M. ISSN 0022-3417.
- ↑ Cha, Wonjae; Kim, Min-Su; Ahn, Jae-Chul; Cho, Sung-Woo; Sunwoo, Woongsang; Song, Chang Myeon; Kwon, Tack-Kyun; Sung, Myung-Whun; Kim, Kwang Hyun (2011). "Clinical Analysis of Acinic Cell Carcinoma in Parotid Gland". Clinical and Experimental Otorhinolaryngology. 4 (4): 188. doi:10.3342/ceo.2011.4.4.188. ISSN 1976-8710.
- ↑ Sherwani, Rana; Akhtar, Kafil; Ahmad, Murad; Hasan, Abrar (2011). "Cytologic diagnosis of acinic cell carcinoma of minor salivary gland: a distinct rarely described entity". Clinics and Practice. 1 (3): 58. doi:10.4081/cp.2011.e58. ISSN 2039-7283.
- ↑ Ishikawa, S; Ishikawa, H; Fuyama, S; Kobayashi, T; Waki, T; Taira, Y; Iino, M (2016). "Report of a case of acinic cell carcinoma of the upper lip and review of Japanese cases of acinic cell carcinoma of the minor salivary glands". Journal of Clinical and Experimental Dentistry: 0–0. doi:10.4317/jced.53049. ISSN 1989-5488.
- ↑ Spiro, Ronald H.; Huvos, Andrew G.; Strong, Elliot W. (1978). "Acinic cell carcinoma of salivary origin.A clinicopathologic study of 67 cases". Cancer. 41 (3): 924–935. doi:10.1002/1097-0142(197803)41:3<924::AID-CNCR2820410321>3.0.CO;2-L. ISSN 0008-543X.
- ↑ Batsakis, John G.; Luna, Mario A.; El-Naggar, Adel K. (2016). "Histopathologic Grading of Salivary Gland Neoplasms: II. Acinic Cell Carcinomas". Annals of Otology, Rhinology & Laryngology. 99 (11): 929–933. doi:10.1177/000348949009901115. ISSN 0003-4894.
- ↑ Lewis, Jean E.; Olsen, Kerry D.; Weiland, Louis H. (1991). "Acinic cell carcinoma. Clinicopathologic review". Cancer. 67 (1): 172–179. doi:10.1002/1097-0142(19910101)67:1<172::AID-CNCR2820670129>3.0.CO;2-X. ISSN 0008-543X.
- ↑ Seifert, Gerhard (1992). "Histopathology of malignant salivary gland tumours". European Journal of Cancer Part B: Oral Oncology. 28 (1): 49–56. doi:10.1016/0964-1955(92)90013-Q. ISSN 0964-1955.
- ↑ Geiger, Jessica L.; García, Joaquín J.; Price, Katharine A.R. (2014). "Acinic Cell Carcinoma of the Salivary Gland with Metastatic Spread to the Pancreas". Case Reports in Oncology. 7 (1): 195–198. doi:10.1159/000360395. ISSN 1662-6575.