Metabolic syndrome medical therapy: Difference between revisions

Jump to navigation Jump to search
Line 7: Line 7:


==Treatment==
==Treatment==
The goal is to get the LDL down to < 100 mg/dl. The first line treatment is change of lifestyle (i.e., caloric restriction and physical activity). However, drug treatment is frequently required. Generally, the individual diseases that comprise the metabolic syndrome are treated separately (e.g. [[diuretic]]s and [[ACE inhibitor]]s for [[hypertension]]). Cholesterol drugs may be used to lower LDL cholesterol and triglyceride levels, if they are elevated, and to raise HDL levels if they are low. Use of drugs that decrease [[insulin resistance]] e.g., [[metformin]] and [[thiazolidinedione]]s is controversial and not FDA approved.


A recent study indicated that cardiovascular exercise was therapeutic in approximately 31% of cases. The most probable benefit was to triglyceride levels, with 43% showing improvement; conversely 91% of test subjects did not exhibit a decrease in fasting plasma glucose or insulin resistance.<ref name="katzmaryk">{{cite journal
* The first line treatment is change of lifestyle (i.e., caloric restriction and physical activity). However, drug treatment is frequently required.  
  | last = Katzmaryk,
  | first = Peter T
  | coauthors = Leon, Arthur S.; Wilmore, Jack H.; Skinner, James S.; Rao, D. C.; Rankinen, Tuomo; Bouchard, Claude
  | title = Targeting the Metabolic Syndrome with Exercise: Evidence from the HERITAGE Family Study.
  | journal = Med. Sci. Sports Exerc
  | volume = 35
  | issue = 10
  | pages = 1703-1709
  | date = [[October 2003]]
  | url = http://www.ms-se.com/pt/re/msse/abstract.00005768-200310000-00013.htm
  | accessdate = 2007-06-24 }}
</ref>
Many other studies have supported the value of increased physical activity along with restricted calories in metabolic syndrome.


* Generally, the individual diseases that comprise the metabolic syndrome are treated separately
** Hypertension - [[Diuretic]]s and [[ACE inhibitor]]s.
** Cholesterol drugs may be used to lower LDL cholesterol and triglyceride levels, if they are elevated, and to raise HDL levels if they are low. The goal is to get the LDL down to < 100 mg/dl.
**Use of drugs that decrease [[insulin resistance]] e.g., [[metformin]] and [[thiazolidinedione]]s is controversial and not FDA approved.


==See also==
==See also==

Revision as of 21:45, 28 September 2011

Metabolic syndrome Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Metabolic Syndrome from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Criteria

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Dietary Therapy

Physical Activity

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Tertiary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Metabolic syndrome medical therapy On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Metabolic syndrome medical therapy

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Metabolic syndrome medical therapy

CDC on Metabolic syndrome medical therapy

Metabolic syndrome medical therapy in the news

Blogs on Metabolic syndrome medical therapy

Directions to Hospitals Treating Metabolic syndrome

Risk calculators and risk factors for Metabolic syndrome medical therapy

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.B.B.S. [2]

Overview

Metabolic syndrome is formed by a constellation of medical disorders that increases one's risk for cardiovascular disease and diabetes. It effects a large number of people in a clustered fashion. Management of metabolic syndrome involves dietary modifications, exercise and drug therapy for the complications (diabetes, stroke, angina, myocardial infarction) found associated with these conditions.

Treatment

  • The first line treatment is change of lifestyle (i.e., caloric restriction and physical activity). However, drug treatment is frequently required.
  • Generally, the individual diseases that comprise the metabolic syndrome are treated separately
    • Hypertension - Diuretics and ACE inhibitors.
    • Cholesterol drugs may be used to lower LDL cholesterol and triglyceride levels, if they are elevated, and to raise HDL levels if they are low. The goal is to get the LDL down to < 100 mg/dl.
    • Use of drugs that decrease insulin resistance e.g., metformin and thiazolidinediones is controversial and not FDA approved.

See also

References

Template:WSTemplate:WH