Retinoblastoma history and symptoms: Difference between revisions
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{{CMG}}; {{AE}} {{Sahar}} {{Simrat}} | {{CMG}}; {{AE}} {{Sahar}} {{Simrat}} | ||
==Overview== | ==Overview== | ||
The hallmark of retinoblastoma is [[leukocoria]] which is an abnormal appearance of the retina as viewed through the [[pupil]], also known as amaurotic cat's eye reflex. Other common symptoms include strabismus and proptosis. The clinical presentation depends on the stage of the disease. | The hallmark of retinoblastoma is [[leukocoria]] which is an abnormal appearance of the [[retina]] as viewed through the [[pupil]], also known as amaurotic cat's eye reflex. Other common [[symptoms]] include [[strabismus]] and [[proptosis]]. The [[clinical]] presentation depends on the stage of the [[disease]]. | ||
==History and ymptoms== | ==History and ymptoms== | ||
Clinical features of retinoblatoma are approximately the same in variable studies and the common findings are as follow:<ref name="ChebbiBouguila2014">{{cite journal|last1=Chebbi|first1=A.|last2=Bouguila|first2=H.|last3=Boussaid|first3=S.|last4=Ben Aleya|first4=N.|last5=Zgholi|first5=H.|last6=Malek|first6=I.|last7=Zeghal|first7=I.|last8=Nacef|first8=L.|title=Le profil clinique du rétinoblastome en Tunisie|journal=Journal Français d'Ophtalmologie|volume=37|issue=6|year=2014|pages=442–448|issn=01815512|doi=10.1016/j.jfo.2014.01.009}}</ref><ref name="pmid14654593">{{cite journal |vauthors=Abramson DH, Beaverson K, Sangani P, Vora RA, Lee TC, Hochberg HM, Kirszrot J, Ranjithan M |title=Screening for retinoblastoma: presenting signs as prognosticators of patient and ocular survival |journal=Pediatrics |volume=112 |issue=6 Pt 1 |pages=1248–55 |date=December 2003 |pmid=14654593 |doi= |url=}}</ref><ref name="ShifaGezmu2017">{{cite journal|last1=Shifa|first1=Jemal Zeberga|last2=Gezmu|first2=Alemayehu Mekonnen|title=Presenting signs of retinoblastoma at a tertiary level teaching hospital in Ethiopia|journal=Pan African Medical Journal|volume=28|year=2017|issn=1937-8688|doi=10.11604/pamj.2017.28.66.11199}}</ref> | Clinical [[Features (pattern recognition)|features]] of retinoblatoma are approximately the same in variable studies and the common findings are as follow:<ref name="ChebbiBouguila2014">{{cite journal|last1=Chebbi|first1=A.|last2=Bouguila|first2=H.|last3=Boussaid|first3=S.|last4=Ben Aleya|first4=N.|last5=Zgholi|first5=H.|last6=Malek|first6=I.|last7=Zeghal|first7=I.|last8=Nacef|first8=L.|title=Le profil clinique du rétinoblastome en Tunisie|journal=Journal Français d'Ophtalmologie|volume=37|issue=6|year=2014|pages=442–448|issn=01815512|doi=10.1016/j.jfo.2014.01.009}}</ref><ref name="pmid14654593">{{cite journal |vauthors=Abramson DH, Beaverson K, Sangani P, Vora RA, Lee TC, Hochberg HM, Kirszrot J, Ranjithan M |title=Screening for retinoblastoma: presenting signs as prognosticators of patient and ocular survival |journal=Pediatrics |volume=112 |issue=6 Pt 1 |pages=1248–55 |date=December 2003 |pmid=14654593 |doi= |url=}}</ref><ref name="ShifaGezmu2017">{{cite journal|last1=Shifa|first1=Jemal Zeberga|last2=Gezmu|first2=Alemayehu Mekonnen|title=Presenting signs of retinoblastoma at a tertiary level teaching hospital in Ethiopia|journal=Pan African Medical Journal|volume=28|year=2017|issn=1937-8688|doi=10.11604/pamj.2017.28.66.11199}}</ref> | ||
*Leukocoria (an abnormal appearance of the [[retina]] as viewed through the [[pupil]], also known as amaurotic cat's eye reflex), (Please see below). | *[[Leukocoria]] (an abnormal appearance of the [[retina]] as viewed through the [[pupil]], also known as amaurotic cat's [[Red reflex|eye reflex]]), (Please see below). | ||
*Strabismus (especially when the macula is involved) | *[[Strabismus]] (especially when the [[macula]] is involved) | ||
*Decreased visual acquity | *Decreased visual acquity | ||
*Painful red eye | *Painful [[red eye]] | ||
*Anterior scleral staphyloma | *Anterior scleral staphyloma | ||
*Hyphema | *[[Hyphema]] | ||
*Buphthalmia | *Buphthalmia | ||
*Loss of vision | *[[Loss of vision]] | ||
Presenting symptoms in adult onset of the tumor are insidious and are such as:<ref name="KhetanSengupta2016">{{cite journal|last1=Khetan|first1=Vikas|last2=Sengupta|first2=Sabyasachi|last3=Pan|first3=Utsab|title=Adult onset retinoblastoma|journal=Indian Journal of Ophthalmology|volume=64|issue=7|year=2016|pages=485|issn=0301-4738|doi=10.4103/0301-4738.190099}}</ref> | Presenting [[symptoms]] in adult onset of the [[tumor]] are insidious and are such as:<ref name="KhetanSengupta2016">{{cite journal|last1=Khetan|first1=Vikas|last2=Sengupta|first2=Sabyasachi|last3=Pan|first3=Utsab|title=Adult onset retinoblastoma|journal=Indian Journal of Ophthalmology|volume=64|issue=7|year=2016|pages=485|issn=0301-4738|doi=10.4103/0301-4738.190099}}</ref> | ||
*Dimness of vision | *[[Vision loss|Dimness of vision]] | ||
*Perception of floater | *Perception of [[Floaters|floater]] | ||
*Pain and redness | *[[Eye Pain|Pain]] and [[Red eye|redness]] | ||
[[File:Retinoblastoma leukocoria.jpeg |thumb|none|200px|T2 MRI showing retinoblastoma<ref name="radio1">Image courtesy of Dr. Frank Gaillard [http://www.radiopaedia.org Radiopaedia] (original file [http://radiopaedia.org/cases/retinoblastoma-leukocoria]).[http://radiopaedia.org/licence Creative Commons BY-SA-NC</ref>]] | [[File:Retinoblastoma leukocoria.jpeg |thumb|none|200px|T2 MRI showing retinoblastoma<ref name="radio1">Image courtesy of Dr. Frank Gaillard [http://www.radiopaedia.org Radiopaedia] (original file [http://radiopaedia.org/cases/retinoblastoma-leukocoria]).[http://radiopaedia.org/licence Creative Commons BY-SA-NC</ref>]] | ||
Advanced and/or metastatic form of the tumor also presents with constitutional symptoms such as: | Advanced and/or [[metastatic]] form of the [[tumor]] also presents with constitutional [[symptoms]] such as: | ||
*Proptosis | *[[Proptosis]] | ||
*Weight loss | *[[Weight loss]] | ||
*Vomiting | *[[Vomiting]] | ||
*Headache | *[[Headache]] | ||
*Neurologic impairement | *[[Neurologic]] impairement | ||
*Orbital mass | *[[Orbital mass causes|Orbital mass]] | ||
==References== | ==References== | ||
Revision as of 17:59, 30 April 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[3] Simrat Sarai, M.D. [4]
Overview
The hallmark of retinoblastoma is leukocoria which is an abnormal appearance of the retina as viewed through the pupil, also known as amaurotic cat's eye reflex. Other common symptoms include strabismus and proptosis. The clinical presentation depends on the stage of the disease.
History and ymptoms
Clinical features of retinoblatoma are approximately the same in variable studies and the common findings are as follow:[1][2][3]
- Leukocoria (an abnormal appearance of the retina as viewed through the pupil, also known as amaurotic cat's eye reflex), (Please see below).
- Strabismus (especially when the macula is involved)
- Decreased visual acquity
- Painful red eye
- Anterior scleral staphyloma
- Hyphema
- Buphthalmia
- Loss of vision
Presenting symptoms in adult onset of the tumor are insidious and are such as:[4]
- Dimness of vision
- Perception of floater
- Pain and redness
Advanced and/or metastatic form of the tumor also presents with constitutional symptoms such as:
- Proptosis
- Weight loss
- Vomiting
- Headache
- Neurologic impairement
- Orbital mass
References
- ↑ Chebbi, A.; Bouguila, H.; Boussaid, S.; Ben Aleya, N.; Zgholi, H.; Malek, I.; Zeghal, I.; Nacef, L. (2014). "Le profil clinique du rétinoblastome en Tunisie". Journal Français d'Ophtalmologie. 37 (6): 442–448. doi:10.1016/j.jfo.2014.01.009. ISSN 0181-5512.
- ↑ Abramson DH, Beaverson K, Sangani P, Vora RA, Lee TC, Hochberg HM, Kirszrot J, Ranjithan M (December 2003). "Screening for retinoblastoma: presenting signs as prognosticators of patient and ocular survival". Pediatrics. 112 (6 Pt 1): 1248–55. PMID 14654593.
- ↑ Shifa, Jemal Zeberga; Gezmu, Alemayehu Mekonnen (2017). "Presenting signs of retinoblastoma at a tertiary level teaching hospital in Ethiopia". Pan African Medical Journal. 28. doi:10.11604/pamj.2017.28.66.11199. ISSN 1937-8688.
- ↑ Khetan, Vikas; Sengupta, Sabyasachi; Pan, Utsab (2016). "Adult onset retinoblastoma". Indian Journal of Ophthalmology. 64 (7): 485. doi:10.4103/0301-4738.190099. ISSN 0301-4738.
- ↑ Image courtesy of Dr. Frank Gaillard Radiopaedia (original file [1]).[http://radiopaedia.org/licence Creative Commons BY-SA-NC