Mucoepidermoid carcinoma medical therapy: Difference between revisions
Jump to navigation
Jump to search
Badria Munir (talk | contribs) No edit summary |
Badria Munir (talk | contribs) No edit summary |
||
| Line 4: | Line 4: | ||
==Overview== | ==Overview== | ||
There is no medical treatment for mucoepidermoid carcinoma. Radiotherapy can be neoadjuvant treatment in some lesions (dependent on the tumor stage and size). | There is no medical treatment for mucoepidermoid carcinoma. [[Radiotherapy]] can be neoadjuvant treatment in some lesions (dependent on the tumor stage and size). | ||
==Medical Therapy== | ==Medical Therapy== | ||
There is no medical treatment for mucoepidermoid carcinoma, However chemotherapy can be used in order to shrink down the tumor. | There is no medical treatment for mucoepidermoid carcinoma, However [[chemotherapy]] can be used in order to shrink down the tumor. [[Chemotherapy]] can be the option for palliative care. Following agents can be used: [[Radiotherapy]] can be neoadjuvant treatment in some lesions (dependent on the tumor stage and size).<ref name="pmid6731349">{{cite journal |vauthors=Evans HL |title=Mucoepidermoid carcinoma of salivary glands: a study of 69 cases with special attention to histologic grading |journal=Am. J. Clin. Pathol. |volume=81 |issue=6 |pages=696–701 |year=1984 |pmid=6731349 |doi= |url=}}</ref><ref name="pmid6731349">{{cite journal |vauthors=Evans HL |title=Mucoepidermoid carcinoma of salivary glands: a study of 69 cases with special attention to histologic grading |journal=Am. J. Clin. Pathol. |volume=81 |issue=6 |pages=696–701 |year=1984 |pmid=6731349 |doi= |url=}}</ref> | ||
** Doxorubicin | ** [[Doxorubicin]] | ||
** Mitoxantrone | ** [[Mitoxantrone]] | ||
** Vinorelbine, | ** [[Vinorelbine|Vinorelbine,]] | ||
** A new form of 5-fluorouracil called fluoropyrimidine | ** A new form of [[5-fluorouracil]] called fluoropyrimidine | ||
* Newer combinations with antimicrotubule agents such as cisplatin has shown some efficacy in malignant tumors. | * Newer combinations with [[Antimicrotubule agent|antimicrotubule agents]] such as [[cisplatin]] has shown some efficacy in malignant tumors. | ||
* Paclitaxel has demonstrated moderate activity against mucoepidermoid tumors and adenocarcinomas but no effect adenoid cystic carcinoma.<ref name="pmid19052760">{{cite journal |vauthors=Stenner M, Klussmann JP |title=Current update on established and novel biomarkers in salivary gland carcinoma pathology and the molecular pathways involved |journal=Eur Arch Otorhinolaryngol |volume=266 |issue=3 |pages=333–41 |date=March 2009 |pmid=19052760 |doi=10.1007/s00405-008-0882-7 |url=}}</ref> | * [[Paclitaxel]] has demonstrated moderate activity against mucoepidermoid tumors and [[adenocarcinomas]] but no effect adenoid cystic carcinoma.<ref name="pmid19052760">{{cite journal |vauthors=Stenner M, Klussmann JP |title=Current update on established and novel biomarkers in salivary gland carcinoma pathology and the molecular pathways involved |journal=Eur Arch Otorhinolaryngol |volume=266 |issue=3 |pages=333–41 |date=March 2009 |pmid=19052760 |doi=10.1007/s00405-008-0882-7 |url=}}</ref> | ||
*Various biological agents under investigation are: | *Various biological agents under investigation are: | ||
** Trastuzumab | ** [[Trastuzumab]] | ||
** Imatinib | ** [[Imatinib]] | ||
** Cetuximab | ** [[Cetuximab]] | ||
===Radiotherapy=== | ===Radiotherapy=== | ||
[[Radiotherapy]] can be used alone in non resecatable tumors as well as adjuvant therapy after surgery and [[chemotherapy]]. Various techniques using radiotherapy has demonstrated significant efficiacy in treatment of salivary gland tumors: | |||
Various techniques using radiotherapy has | ** Gamma-knife [[stereotactic radiosurgery]] | ||
** Gamma-knife stereotactic radiosurgery | ** [[Brachytherapy]] | ||
** Brachytherapy | ** [[Iodine-125]] | ||
** Iodine-125 | ** [[Proton]] based radiation | ||
** Proton based radiation | ** [[Neutron]] therapy<ref name="pmid30630270">{{cite journal |vauthors=Park G, Lee SW |title=Postoperative radiotherapy for mucoepidermoid carcinoma of the major salivary glands: long-term results of a single-institution experience |journal=Radiat Oncol J |volume=36 |issue=4 |pages=317–324 |date=December 2018 |pmid=30630270 |doi=10.3857/roj.2018.00409 |url=}}</ref> | ||
** Neutron therapy<ref name="pmid30630270">{{cite journal |vauthors=Park G, Lee SW |title=Postoperative radiotherapy for mucoepidermoid carcinoma of the major salivary glands: long-term results of a single-institution experience |journal=Radiat Oncol J |volume=36 |issue=4 |pages=317–324 |date=December 2018 |pmid=30630270 |doi=10.3857/roj.2018.00409 |url=}}</ref> | |||
==References== | ==References== | ||
| Line 34: | Line 33: | ||
{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
[[Category:Disease]] | [[Category:Disease]] | ||
Latest revision as of 19:39, 22 January 2019
|
Mucoepidermoid carcinoma Microchapters |
|
Differentiating Mucoepidermoid Carcinoma from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Mucoepidermoid carcinoma medical therapy On the Web |
|
American Roentgen Ray Society Images of Mucoepidermoid carcinoma medical therapy |
|
Risk calculators and risk factors for Mucoepidermoid carcinoma medical therapy |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Badria Munir M.B.B.S.[2] , Maria Fernanda Villarreal, M.D. [3]
Overview
There is no medical treatment for mucoepidermoid carcinoma. Radiotherapy can be neoadjuvant treatment in some lesions (dependent on the tumor stage and size).
Medical Therapy
There is no medical treatment for mucoepidermoid carcinoma, However chemotherapy can be used in order to shrink down the tumor. Chemotherapy can be the option for palliative care. Following agents can be used: Radiotherapy can be neoadjuvant treatment in some lesions (dependent on the tumor stage and size).[1][1]
- Doxorubicin
- Mitoxantrone
- Vinorelbine,
- A new form of 5-fluorouracil called fluoropyrimidine
- Newer combinations with antimicrotubule agents such as cisplatin has shown some efficacy in malignant tumors.
- Paclitaxel has demonstrated moderate activity against mucoepidermoid tumors and adenocarcinomas but no effect adenoid cystic carcinoma.[2]
- Various biological agents under investigation are:
Radiotherapy
Radiotherapy can be used alone in non resecatable tumors as well as adjuvant therapy after surgery and chemotherapy. Various techniques using radiotherapy has demonstrated significant efficiacy in treatment of salivary gland tumors:
- Gamma-knife stereotactic radiosurgery
- Brachytherapy
- Iodine-125
- Proton based radiation
- Neutron therapy[3]
References
- ↑ 1.0 1.1 Evans HL (1984). "Mucoepidermoid carcinoma of salivary glands: a study of 69 cases with special attention to histologic grading". Am. J. Clin. Pathol. 81 (6): 696–701. PMID 6731349.
- ↑ Stenner M, Klussmann JP (March 2009). "Current update on established and novel biomarkers in salivary gland carcinoma pathology and the molecular pathways involved". Eur Arch Otorhinolaryngol. 266 (3): 333–41. doi:10.1007/s00405-008-0882-7. PMID 19052760.
- ↑ Park G, Lee SW (December 2018). "Postoperative radiotherapy for mucoepidermoid carcinoma of the major salivary glands: long-term results of a single-institution experience". Radiat Oncol J. 36 (4): 317–324. doi:10.3857/roj.2018.00409. PMID 30630270.