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{{ | '''Glia-derived nexin''' is a [[protein]] that in humans is encoded by the ''SERPINE2'' [[gene]].<ref name="pmid7665170">{{cite journal |vauthors=Carter RE, Cerosaletti KM, Burkin DJ, Fournier RE, Jones C, Greenberg BD, Citron BA, Festoff BW | title = The gene for the serpin thrombin inhibitor (PI7), protease nexin I, is located on human chromosome 2q33-q35 and on syntenic regions in the mouse and sheep genomes | journal = Genomics | volume = 27 | issue = 1 | pages = 196–9 |date=Oct 1995 | pmid = 7665170 | pmc = | doi =10.1006/geno.1995.1025 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5270| accessdate = }}</ref> | ||
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==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
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| citations = | | citations = | ||
*{{cite journal | author=Naldini L | *{{cite journal | author=Naldini L |title=Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor |journal=EMBO J. |volume=11 |issue= 13 |pages= 4825–33 |year= 1993 |pmid= 1334458 |doi= | pmc=556958 |name-list-format=vanc| author2=Tamagnone L | author3=Vigna E | display-authors=3 | last4=Sachs | first4=M | last5=Hartmann | first5=G | last6=Birchmeier | first6=W | last7=Daikuhara | first7=Y | last8=Tsubouchi | first8=H | last9=Blasi | first9=F }} | ||
*{{cite journal | author=Gloor S |title=A glia-derived neurite promoting factor with protease inhibitory activity belongs to the protease nexins |journal=Cell |volume=47 |issue= 5 |pages= 687–93 |year= 1987 |pmid= 2877744 |doi=10.1016/0092-8674(86)90511-8 |name-list-format=vanc| author2=Odink K | author3=Guenther J | display-authors=3 | last4=Nick | first4=Hanspeter | last5=Monard | first5=Denis }} | |||
*{{cite journal | author= | *{{cite journal | author=Sommer J |title=cDNA sequence coding for a rat glia-derived nexin and its homology to members of the serpin superfamily |journal=Biochemistry |volume=26 |issue= 20 |pages= 6407–10 |year= 1988 |pmid= 3427015 |doi=10.1021/bi00394a016 |name-list-format=vanc| author2=Gloor SM | author3=Rovelli GF | display-authors=3 | last4=Hofsteenge | first4=Jan | last5=Nick | first5=Hanspeter | last6=Meier | first6=Roland | last7=Monard | first7=Denis }} | ||
*{{cite journal | author=Scott RW |title=Protease nexin. Properties and a modified purification procedure |journal=J. Biol. Chem. |volume=260 |issue= 11 |pages= 7029–34 |year= 1985 |pmid= 3997857 |doi= |name-list-format=vanc| author2=Bergman BL | author3=Bajpai A | display-authors=3 | last4=Hersh | first4=RT | last5=Rodriguez | first5=H | last6=Jones | first6=BN | last7=Barreda | first7=C | last8=Watts | first8=S | last9=Baker | first9=JB }} | |||
*{{cite journal | author= | *{{cite journal |vauthors=Magnaldo T, Bernerd F, Darmon M |title=Galectin-7, a human 14-kDa S-lectin, specifically expressed in keratinocytes and sensitive to retinoic acid |journal=Dev. Biol. |volume=168 |issue= 2 |pages= 259–71 |year= 1995 |pmid= 7729568 |doi= 10.1006/dbio.1995.1078 }} | ||
*{{cite journal |vauthors=Donovan FM, Vaughan PJ, Cunningham DD |title=Regulation of protease nexin-1 target protease specificity by collagen type IV |journal=J. Biol. Chem. |volume=269 |issue= 25 |pages= 17199–205 |year= 1994 |pmid= 8006028 |doi= }} | |||
*{{cite journal | author= | *{{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }} | ||
*{{cite journal | author=Nykjaer A |title=Recycling of the urokinase receptor upon internalization of the uPA:serpin complexes |journal=EMBO J. |volume=16 |issue= 10 |pages= 2610–20 |year= 1997 |pmid= 9184208 |doi= 10.1093/emboj/16.10.2610 | pmc=1169872 |name-list-format=vanc| author2=Conese M | author3=Christensen EI | display-authors=3 | last4=Olson | first4=D | last5=Cremona | first5=O | last6=Gliemann | first6=J | last7=Blasi | first7=F }} | |||
*{{cite journal | | *{{cite journal | author=Suzuki Y |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |name-list-format=vanc| author2=Yoshitomo-Nakagawa K | author3=Maruyama K | display-authors=3 | last4=Suyama | first4=Akira | last5=Sugano | first5=Sumio }} | ||
*{{cite journal | | *{{cite journal |vauthors=Li Y, Lu YY |title=Applying a highly specific and reproducible cDNA RDA method to clone garlic up-regulated genes in human gastric cancer cells |journal=World J. Gastroenterol. |volume=8 |issue= 2 |pages= 213–6 |year= 2002 |pmid= 11925594 |doi= }} | ||
*{{cite journal | | *{{cite journal |vauthors=Grabham PW, Monard D, Gallimore PH, Grand RJ |title=Modulation of Human Neurite Outgrowth by Serine Proteases: A Comparison of the Interaction of Thrombin and Prothrombin with Glia-Derived Nexin |journal= The European Journal of Neuroscience|volume=3 |issue= 7 |pages= 663–668 |year= 1991|pmid= 12106474 |doi=10.1111/j.1460-9568.1991.tb00852.x }} | ||
*{{cite journal | author= | *{{cite journal |vauthors=Crisp RJ, Knauer MF, Knauer DJ |title=Protease nexin 1 is a potent urinary plasminogen activator inhibitor in the presence of collagen type IV |journal=J. Biol. Chem. |volume=277 |issue= 49 |pages= 47285–91 |year= 2003 |pmid= 12356769 |doi= 10.1074/jbc.M204813200 }} | ||
*{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }} | |||
*{{cite journal | author= | *{{cite journal | author=Petrovic D |title=Prothrombotic gene polymorphisms and atherothrombotic cerebral infarction |journal=Acta Neurol. Scand. |volume=108 |issue= 2 |pages= 109–13 |year= 2003 |pmid= 12859287 |doi=10.1034/j.1600-0404.2003.00126.x |name-list-format=vanc| author2=Milanez T | author3=Kobal J | display-authors=3 | last4=Bregar | first4=D. | last5=Potisk | first5=K. P. | last6=Peterlin | first6=B. }} | ||
*{{cite journal |vauthors=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819–24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504 | pmc=2286551 }} | |||
*{{cite journal | | *{{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-format=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }} | ||
*{{cite journal | | *{{cite journal | author=Kim JA |title=Brain endothelial hemostasis regulation by pericytes |journal=J. Cereb. Blood Flow Metab. |volume=26 |issue= 2 |pages= 209–17 |year= 2006 |pmid= 16015279 |doi= 10.1038/sj.jcbfm.9600181 |name-list-format=vanc| author2=Tran ND | author3=Li Z | display-authors=3 | last4=Yang | first4=Fan | last5=Zhou | first5=Weilin | last6=Fisher | first6=Mark J }} | ||
*{{cite journal | | *{{cite journal | author=Navaneetham D |title=Structural and mutational analyses of the molecular interactions between the catalytic domain of factor XIa and the Kunitz protease inhibitor domain of protease nexin 2 |journal=J. Biol. Chem. |volume=280 |issue= 43 |pages= 36165–75 |year= 2006 |pmid= 16085935 |doi= 10.1074/jbc.M504990200 |name-list-format=vanc| author2=Jin L | author3=Pandey P | display-authors=3 | last4=Strickler | first4=JE | last5=Babine | first5=RE | last6=Abdel-Meguid | first6=SS | last7=Walsh | first7=PN }} | ||
*{{cite journal | author= | *{{cite journal | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |name-list-format=vanc| author2=Venkatesan K | author3=Hao T | display-authors=3 | last4=Hirozane-Kishikawa | first4=Tomoko | last5=Dricot | first5=Amélie | last6=Li | first6=Ning | last7=Berriz | first7=Gabriel F. | last8=Gibbons | first8=Francis D. | last9=Dreze | first9=Matija }} | ||
}} | }} | ||
{{refend}} | {{refend}} | ||
==External links== | ==External links== | ||
* The [[MEROPS]] online database for peptidases and their inhibitors: [http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=I04.021 I04.021] | |||
* {{MeshName|SERPINE2+protein,+human}} | * {{MeshName|SERPINE2+protein,+human}} | ||
{{Serpins}} | {{Serpins}} | ||
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[[Category:Serine protease inhibitors]] | [[Category:Serine protease inhibitors]] | ||
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{{gene-2-stub}} | |||
Revision as of 06:09, 11 September 2017
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| External IDs | GeneCards: [1] | ||||||
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| Species | Human | Mouse | |||||
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| Ensembl |
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| UniProt |
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| RefSeq (mRNA) |
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| RefSeq (protein) |
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| Location (UCSC) | n/a | n/a | |||||
| PubMed search | n/a | n/a | |||||
| Wikidata | |||||||
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Glia-derived nexin is a protein that in humans is encoded by the SERPINE2 gene.[1][2]
See also
References
- ↑ Carter RE, Cerosaletti KM, Burkin DJ, Fournier RE, Jones C, Greenberg BD, Citron BA, Festoff BW (Oct 1995). "The gene for the serpin thrombin inhibitor (PI7), protease nexin I, is located on human chromosome 2q33-q35 and on syntenic regions in the mouse and sheep genomes". Genomics. 27 (1): 196–9. doi:10.1006/geno.1995.1025. PMID 7665170.
- ↑ "Entrez Gene: SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2".
Further reading
- Naldini L, Tamagnone L, Vigna E, et al. (1993). "Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor". EMBO J. 11 (13): 4825–33. PMC 556958. PMID 1334458.
- Gloor S, Odink K, Guenther J, et al. (1987). "A glia-derived neurite promoting factor with protease inhibitory activity belongs to the protease nexins". Cell. 47 (5): 687–93. doi:10.1016/0092-8674(86)90511-8. PMID 2877744.
- Sommer J, Gloor SM, Rovelli GF, et al. (1988). "cDNA sequence coding for a rat glia-derived nexin and its homology to members of the serpin superfamily". Biochemistry. 26 (20): 6407–10. doi:10.1021/bi00394a016. PMID 3427015.
- Scott RW, Bergman BL, Bajpai A, et al. (1985). "Protease nexin. Properties and a modified purification procedure". J. Biol. Chem. 260 (11): 7029–34. PMID 3997857.
- Magnaldo T, Bernerd F, Darmon M (1995). "Galectin-7, a human 14-kDa S-lectin, specifically expressed in keratinocytes and sensitive to retinoic acid". Dev. Biol. 168 (2): 259–71. doi:10.1006/dbio.1995.1078. PMID 7729568.
- Donovan FM, Vaughan PJ, Cunningham DD (1994). "Regulation of protease nexin-1 target protease specificity by collagen type IV". J. Biol. Chem. 269 (25): 17199–205. PMID 8006028.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Nykjaer A, Conese M, Christensen EI, et al. (1997). "Recycling of the urokinase receptor upon internalization of the uPA:serpin complexes". EMBO J. 16 (10): 2610–20. doi:10.1093/emboj/16.10.2610. PMC 1169872. PMID 9184208.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Li Y, Lu YY (2002). "Applying a highly specific and reproducible cDNA RDA method to clone garlic up-regulated genes in human gastric cancer cells". World J. Gastroenterol. 8 (2): 213–6. PMID 11925594.
- Grabham PW, Monard D, Gallimore PH, Grand RJ (1991). "Modulation of Human Neurite Outgrowth by Serine Proteases: A Comparison of the Interaction of Thrombin and Prothrombin with Glia-Derived Nexin". The European Journal of Neuroscience. 3 (7): 663–668. doi:10.1111/j.1460-9568.1991.tb00852.x. PMID 12106474.
- Crisp RJ, Knauer MF, Knauer DJ (2003). "Protease nexin 1 is a potent urinary plasminogen activator inhibitor in the presence of collagen type IV". J. Biol. Chem. 277 (49): 47285–91. doi:10.1074/jbc.M204813200. PMID 12356769.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Petrovic D, Milanez T, Kobal J, et al. (2003). "Prothrombotic gene polymorphisms and atherothrombotic cerebral infarction". Acta Neurol. Scand. 108 (2): 109–13. doi:10.1034/j.1600-0404.2003.00126.x. PMID 12859287.
- Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Kim JA, Tran ND, Li Z, et al. (2006). "Brain endothelial hemostasis regulation by pericytes". J. Cereb. Blood Flow Metab. 26 (2): 209–17. doi:10.1038/sj.jcbfm.9600181. PMID 16015279.
- Navaneetham D, Jin L, Pandey P, et al. (2006). "Structural and mutational analyses of the molecular interactions between the catalytic domain of factor XIa and the Kunitz protease inhibitor domain of protease nexin 2". J. Biol. Chem. 280 (43): 36165–75. doi:10.1074/jbc.M504990200. PMID 16085935.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
External links
- The MEROPS online database for peptidases and their inhibitors: I04.021
- SERPINE2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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