Chronic lymphocytic leukemia other diagnostic studies: Difference between revisions
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===Bone Marrow Biopsy=== | ===Bone Marrow Biopsy=== | ||
* [[Bone marrow biopsy]] and [[lymph node biopsy]] may be helpful in the diagnosis of chronic lymphocytic leukimea. Histopathological findings on biopsy can be found | |||
[[Bone marrow biopsy]] is not required in all cases of chronic lymphocytic leukemia. It is used to establish the findings of [[anemia]] and [[thrombocytopenia]]. It can distinguish between thrombocytopenia of peripheral destruction (in the spleen) and that due to marrow infiltration. | [[Bone marrow biopsy]] is not required in all cases of chronic lymphocytic leukemia. It is used to establish the findings of [[anemia]] and [[thrombocytopenia]]. It can distinguish between thrombocytopenia of peripheral destruction (in the spleen) and that due to marrow infiltration. | ||
Revision as of 20:54, 14 October 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]
Overview
Bone Marrow Biopsy
- Bone marrow biopsy and lymph node biopsy may be helpful in the diagnosis of chronic lymphocytic leukimea. Histopathological findings on biopsy can be found
Bone marrow biopsy is not required in all cases of chronic lymphocytic leukemia. It is used to establish the findings of anemia and thrombocytopenia. It can distinguish between thrombocytopenia of peripheral destruction (in the spleen) and that due to marrow infiltration.
Common biopsy methods used are:
- Bone marrow aspiration and biopsy
- Excisional lymph node biopsy
Cytogenetic Tests
- Detects any chromosomal mutations occurring in chronic lymphocytic leukemia. Common genetic mutations involved in the development of chronic lymphocytic leukemia can be found here.[1]
Fluorescent in situ hybridization
- Detects any chromosomal mutations occurring in chronic lymphocytic leukemia. Common genetic mutations involved in the development of chronic lymphocytic leukemia can be found here.[1]
References
- ↑ 1.0 1.1 Hallek M (2015). "Chronic lymphocytic leukemia: 2015 Update on diagnosis, risk stratification, and treatment". Am J Hematol. 90 (5): 446–60. doi:10.1002/ajh.23979. PMID 25908509.