Metabolic acidosis future or investigational therapies: Difference between revisions

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==== <u><big>Experimental Treatment:</big></u> ====
====<u><big>Experimental Treatment:</big></u>====
Small animal studies of various models of shock and lactic acidosis demonstrated improved cardiac function, reduced mortality, and decreased generation of pro-inflammatory cytokines; human studies yet to be performed, so options include as follows:
Small animal studies of various models of [[shock]] and [[lactic acidosis]] demonstrated improved [[cardiac]] function, reduced [[mortality]], and decreased generation of pro-inflammatory [[cytokines]]; human studies yet to be performed, so options include as follows:


# Dichloroacetate
#[[Dichloroacetate]]
# Administration of selective inhibitors Na+-H+ Exchanger 1 or amilonde analogues
#Administration of [[selective inhibitors Na+-H+ Exchanger]] 1 or [[amiloride]] analogues
# Administration of inhibitors of transient receptor potential vanilloid 1
#Administration of inhibitors of transient receptor potential vanilloid 1
# Administration of selective inhibitors acid sensing Ion channel la
#Administration of selective inhibitors acid sensing [[Ion channels|Ion channel]] la
# Administration of inhibitors of mitogen activated protein kinase
#Administration of inhibitors of [[mitogen]] activated protein [[Protein kinase inhibitor|kinase]]


==References==
==References==

Latest revision as of 20:09, 19 February 2021



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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Experimental Treatment:

Small animal studies of various models of shock and lactic acidosis demonstrated improved cardiac function, reduced mortality, and decreased generation of pro-inflammatory cytokines; human studies yet to be performed, so options include as follows:

  1. Dichloroacetate
  2. Administration of selective inhibitors Na+-H+ Exchanger 1 or amiloride analogues
  3. Administration of inhibitors of transient receptor potential vanilloid 1
  4. Administration of selective inhibitors acid sensing Ion channel la
  5. Administration of inhibitors of mitogen activated protein kinase

References

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