Eosinophilic pneumonia natural history, complications, and prognosis: Difference between revisions
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==Overview== | ==Overview== | ||
If left untreated, patients with eosinophilic pneumonia may progress to develop dyspnea, pleural effusion, and respiratory failure. Common complications of eosinophilic pneumonia include [[Respiratory failure|respiratory failure,]] [[relapse]], and [[Adverse effect (medicine)|adverse effects]] of [[Steroid|steroids]]. Prognosis is generally excellent, and only a couple of lethal cases have been reported. | |||
==Natural History== | ==Natural History== | ||
If left untreated, patients with eosinophilic pneumonia may progress to develop dyspnea, pleural effusion, and respiratory failure. | |||
==Complications== | ==Complications== | ||
* Chronic [[prednisone]] is associated with many side effects, including [[Immunosuppression|increased infections]], [[Bone fracture|weakened bones]], [[Peptic ulcer|stomach ulcers]], and changes in appearance.{{ref|Naughton}} | |||
* [[Relapse]]: Relapses of ICEP are observed in up to 50% of patients. Relapses occur while tapering the dose of [[corticosteroids]] or after weaning. | |||
* [[Respiratory failure]]: Only a couple of lethal cases have been reported. | |||
== Prognosis == | == Prognosis == | ||
* Some patients with ICEP require lifelong therapy.<ref name="pmid12403693">{{cite journal| author=Philit F, Etienne-Mastroïanni B, Parrot A, Guérin C, Robert D, Cordier JF| title=Idiopathic acute eosinophilic pneumonia: a study of 22 patients. | journal=Am J Respir Crit Care Med | year= 2002 | volume= 166 | issue= 9 | pages= 1235-9 | pmid=12403693 | doi=10.1164/rccm.2112056 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12403693 }}</ref> | |||
* Response to [[corticosteroid]] treatment is dramatic and treatment always leads to complete resolution, [[pulmonary function tests]] return to normal after recovery from the illness.<ref name="pmid12403693" /> | |||
* The [[pleural effusions]] may resolve more slowly than the [[Parenchyma|pulmonary parenchymal]] opacities.<ref name="pmid8982150">{{cite journal| author=Pope-Harman AL, Davis WB, Allen ED, Christoforidis AJ, Allen JN| title=Acute eosinophilic pneumonia. A summary of 15 cases and review of the literature. | journal=Medicine (Baltimore) | year= 1996 | volume= 75 | issue= 6 | pages= 334-42 | pmid=8982150 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8982150 }}</ref> | |||
* [[Relapse|Relapses]] of ICEP are observed in up to 50% of patients and is usually associated with resumption of cigarette smoking after initial cessation. | |||
* These relapses occur while tapering the dose of [[corticosteroids]] or after weaning.<ref name="pmid22599359">{{cite journal| author=Rhee CK, Min KH, Yim NY, Lee JE, Lee NR, Chung MP et al.| title=Clinical characteristics and corticosteroid treatment of acute eosinophilic pneumonia. | journal=Eur Respir J | year= 2013 | volume= 41 | issue= 2 | pages= 402-9 | pmid=22599359 | doi=10.1183/09031936.00221811 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22599359 }}</ref> | |||
and | |||
These relapses occur while tapering the dose of corticosteroids | |||
or after weaning. | |||
==References== | ==References== | ||
Latest revision as of 19:55, 27 March 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Priyamvada Singh, M.D. [2]
Overview
If left untreated, patients with eosinophilic pneumonia may progress to develop dyspnea, pleural effusion, and respiratory failure. Common complications of eosinophilic pneumonia include respiratory failure, relapse, and adverse effects of steroids. Prognosis is generally excellent, and only a couple of lethal cases have been reported.
Natural History
If left untreated, patients with eosinophilic pneumonia may progress to develop dyspnea, pleural effusion, and respiratory failure.
Complications
- Chronic prednisone is associated with many side effects, including increased infections, weakened bones, stomach ulcers, and changes in appearance.[3]
- Relapse: Relapses of ICEP are observed in up to 50% of patients. Relapses occur while tapering the dose of corticosteroids or after weaning.
- Respiratory failure: Only a couple of lethal cases have been reported.
Prognosis
- Some patients with ICEP require lifelong therapy.[1]
- Response to corticosteroid treatment is dramatic and treatment always leads to complete resolution, pulmonary function tests return to normal after recovery from the illness.[1]
- The pleural effusions may resolve more slowly than the pulmonary parenchymal opacities.[2]
- Relapses of ICEP are observed in up to 50% of patients and is usually associated with resumption of cigarette smoking after initial cessation.
- These relapses occur while tapering the dose of corticosteroids or after weaning.[3]
References
- ↑ 1.0 1.1 Philit F, Etienne-Mastroïanni B, Parrot A, Guérin C, Robert D, Cordier JF (2002). "Idiopathic acute eosinophilic pneumonia: a study of 22 patients". Am J Respir Crit Care Med. 166 (9): 1235–9. doi:10.1164/rccm.2112056. PMID 12403693.
- ↑ Pope-Harman AL, Davis WB, Allen ED, Christoforidis AJ, Allen JN (1996). "Acute eosinophilic pneumonia. A summary of 15 cases and review of the literature". Medicine (Baltimore). 75 (6): 334–42. PMID 8982150.
- ↑ Rhee CK, Min KH, Yim NY, Lee JE, Lee NR, Chung MP; et al. (2013). "Clinical characteristics and corticosteroid treatment of acute eosinophilic pneumonia". Eur Respir J. 41 (2): 402–9. doi:10.1183/09031936.00221811. PMID 22599359.