Thin basement membrane disease diagnostic study of choice

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Diagnostic Study of Choice

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Marufa Marium, M.B.B.S[2]

Overview

Renal biopsy is the gold standard test for TBMD. The WHO guideline for normal GBM thickness is 250nm for adult and 180nm for children of 2-11 years of age. Diffuse thinning of 50% of glomerular basement membrane in glomerular capillaries is the criteria for diagnosing TBMD on Electron microscopy.

Diagnostic study of choice

The following result of Renal biopsy is confirmatory of TBMD:

References

  1. Foster K, Markowitz GS, D'Agati VD (May 2005). "Pathology of thin basement membrane nephropathy". Semin Nephrol. 25 (3): 149–58. doi:10.1016/j.semnephrol.2005.01.006. PMID 15880325.
  2. Vogler C, McAdams AJ, Homan SM (1987). "Glomerular basement membrane and lamina densa in infants and children: an ultrastructural evaluation". Pediatr Pathol. 7 (5–6): 527–34. doi:10.3109/15513818709161416. PMID 3449814.
  3. "Thin Basement Membrane Nephropathy | American Society of Nephrology".
  4. Gubler MC, Knebelmann B, Beziau A, Broyer M, Pirson Y, Haddoum F, Kleppel MM, Antignac C (April 1995). "Autosomal recessive Alport syndrome: immunohistochemical study of type IV collagen chain distribution". Kidney Int. 47 (4): 1142–7. doi:10.1038/ki.1995.163. PMID 7783412.

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