Terlipressin
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| Terlipressin
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| Systematic (IUPAC) name | |
| (2S)-1-[(4S,7S,10S,13S,16S,19S)-19-[[2- [[2-[(2-Aminoacetyl)amino]acetyl]amino] acetyl]amino]-13-benzyl-10-(2-carbamoylethyl)- 7-(carbamoylmethyl)-16-[(4-hydroxyphenyl) methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8, 11,14,17-pentazacycloicosane-4-carbonyl]-N- [(1S)-5-amino-1-(carbamoylmethylcarbamoyl) pentyl]pyrrolidine-2-carboxamide | |
| Identifiers | |
| CAS number | |
| ATC code | H01 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C52H74N16O15S2 |
| Mol. mass | 1227.37 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Protein binding | ~30% |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | IV |
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Terlipressin is an analogue of vasopressin used as a vasoactive drug in the management of hypotension. It has been found to be effective when norepinephrine does not help.
Indications for use include norepinephrine-resistant septic shock[1] and hepatorenal syndrome.[1] In addition, it is used in bleeding esophageal varices.[1]
Terlipressin is marketed under the brand name Glypressin (Ferring Pharmaceuticals).
See also
References
Pituitary and hypothalamic hormones and analogues (H01) | |
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| Anterior pituitary | Adrenocorticotropic hormone (Corticotropin, Tetracosactide) - Thyrotropin - Somatropin/agonists (Somatrem, Mecasermin, Sermorelin) - other (Pegvisomant) |
| Posterior pituitary | Vasopressin (Desmopressin, Lypressin, Terlipressin, Ornipressin, Argipressin) - Oxytocin (Demoxytocin, Carbetocin) |
| Hypothalamic | gonadotropin-releasing hormones (Gonadorelin, Nafarelin, Histrelin) - antigrowth hormone (Somatostatin, Octreotide, Lanreotide) - anti-gonadotropin-releasing hormones (Ganirelix, Cetrorelix) |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
