Spondyloarthropathy risk factors
Spondyloarthropathy risk factors
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Since the role of genetic in the presence of spondyloarthropathies have been known since several years ago, genetically predisposing individuals are who have HLA-B27 gene, are at risk of developing spondyloarthropathies.
The risk of developing spondyloarthropathies in individuals with HLA-B27 gene is 1-2%, however, it can increase to 15-20% if he/she have a first-degree relative with positive HLA-B27 gene and developed spondyloarthropathy.
There some genes that are suspicious for their association in SpA, which are included:
- HLA-B27
- HLA-B*2702 (Association with AS)
- HLA-B*2704 (Association with SpA)
- HLA-B*2705 (Strong association with AS)
- HLA-B*2706 (Very weak association with SpA)
- HLA-B*2709 (AS sparing)
- ERAP1
- IL23R
- TNFRSF1A
- TRADD
- TNFSF15
- IL1A
- IL1R2
- CARD9
- ANTXR2