Spondyloarthropathy epidemiology and demographics

epidemiology and demographics

Spondyloarthropathy Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating spondyloarthropathies from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Study of Choice
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
X-ray
Echocardiography and Ultrasound
CT scan
MRI
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Interventions
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Spondyloarthropathy epidemiology and demographics On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Spondyloarthropathy epidemiology and demographics All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Spondyloarthropathy epidemiology and demographics
CDC on Spondyloarthropathy epidemiology and demographics
Spondyloarthropathy epidemiology and demographics in the news
Blogs on Spondyloarthropathy epidemiology and demographics
Directions to Hospitals Treating Psoriasis
Risk calculators and risk factors for Spondyloarthropathy epidemiology and demographics

Spondyloarthropathy (SpA) is a world wide disease but it has been seen mostly throughout Europe, Asia, North Africa, and North America, which are the places for presence of HLA-B27. SpA and HLA-B27 is somehow absent among genetically unmixed native populations of South Africa and Australia.

Here are some labeled data that shows not only the prevalence of spondyloarthropathies but also the prevalence of HLA-B27 and its subtype.

Prevalence of AS and related spondyloarthropathies throughout different populations
populations	B27 frequency	Prevalence of AS		Prevalence of SpA (including AS)
		General population	B27+ part of population	General population	B27+ part of population
Eskimos (Alaska)	40%	0.4%	..	2.5%	..
Skimos (Alaska & Siberia) & Chukcki	25-40%	..	1.6%	2-3.4%	4.2%
Samis (Lapland)	24%	1.8%	6.8%	..	..
Northern Norway	10-16%	1.4%	..	..	..
Mordovia	16%	0.5%	..	..	..
Europe (Western)	8%	0.2%	2%	..	..

Basic HLA-B27 subtypes and their geographical distribution
HLA-B27 subtype	Geographical appearance	Assocoation
HLA-B*2702	Mediterranean populations	Association with AS
HLA-B*2704	Major subtype in Chinese and Japanese populations	Association with SpA
HLA-B*2705	Major subtype in Caucasians	Strong association with AS
HLA-B*2706	Healthy populations in Southeast Asia	Very weak association with SpA
HLA-B*2709	Healthy population of Sardinia	AS sparing

..