Rickettsia prowazekii
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| Rickettsia prowazekii | ||||||||||||||
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| Rickettsia prowazekii da Rocha-Lima, 1916 |
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Rickettsia prowazekii is a species of gram negative, rod shaped, aerobic bacteria that is the etiologic agent of epidemic typhus, transmitted in the feces of lice and fleas. R. prowazekii is often surrounded by a protein microcapsular layer and slime layer; the natural life cycle of the bacteria generally involves a vertebrate and an invertebrate host, usually an arthropod, typically a louse. A form of R. prowazekii that exists in the feces of arthropods remains stably infective for months. Henrique da Rocha Lima , a brazilian doctor discovered this bacteria, in 1916. Vaccines against R. prowazekii were developed in the 1940s, and were highly effective in reducing typhus deaths among U.S. soldiers during World War II. Immunity following recovery from infection with, or by immunization against, R. prowazekii is lifelong in most cases. However, R. prowazekii can establish a latent infection, which can reactivate after years or decades.
References
- NIAID Biodefense Research Agenda for Category B and C Priority PathogensPDF (1.44 MiB) National Institutes of Health, National Institute of Allergy and Infectious Diseases. NIH Publication No. 03-5315. (January 2003).
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
