Renal cell carcinoma causes

Jump to: navigation, search

Renal cell carcinoma Microchapters


Patient Information


Historical Perspective




Differentiating Renal cell carcinoma from other Diseases

Epidemiology and Demographics

Risk Factors


Natural history, Complications and Prognosis



Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings


Chest X Ray



Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies


Medical Therapy


Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Renal cell carcinoma causes On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides


American Roentgen Ray Society Images of Renal cell carcinoma causes

All Images
Echo & Ultrasound
CT Images

Ongoing Trials at Clinical

US National Guidelines Clearinghouse

NICE Guidance

FDA on Renal cell carcinoma causes

CDC on Renal cell carcinoma causes

Renal cell carcinoma causes in the news

Blogs on Renal cell carcinoma causes

Directions to Hospitals Treating Renal cell carcinoma

Risk calculators and risk factors for Renal cell carcinoma causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Farima Kahe M.D. [2]


The causes of renal cell carcinoma include von hippel-lindau (VHL), hereditary paragangliomas, leiomyomatosis, birt-hogg-dube syndrome, and several other genetic factors.


Sporadic development of renal cell carcinomas contributes to the majority of cases of the most common renal cell carcinoma, the conventional (or clear cell) carcinoma.[1][2][3]

The following tables show the sporadic and hereditary renal-cell carcinomas and associated causes:

Sporadic Forms of Renal Cell Carcinoma

Sporadic Forms of Renal Cell Carcinoma[4]
Histologic Appearance Incidence Gene Frequency
Conventional (Clear Cell) 75 VHL 60 %
Papillary 12 MET
13 %
< 1 %
Chromophobe 4
Oncocytoma 4
Collecting Duct < 1
Unclassified 3 - 5
Adapted from Cohen HT, McGovern FJ. Renal-cell carcinoma.N Engl J Med. 2005; 353:2477-90

Hereditary Forms of Renal Cell Carcinoma

Hereditary Forms of Renal Cell Carcinoma[4]
Syndrome Associated Gene Common Histological Appearance
VHL Disease VHL Conventional (Clear Cell)
FCRC Chromosome 3p translocation Conventional (Clear Cell)
Hereditary Paraganglioma SDHB Conventional (Clear Cell)
HPRC MET Papillary
HLRCC FH Papillary
Birt-Hogg-Dube Syndrome BHD Chromophobe / Oncocytoma
Adapted from Cohen HT, McGovern FJ. Renal-cell carcinoma.N Engl J Med. 2005; 353:2477-90


  1. Haas NB, Nathanson KL (January 2014). "Hereditary kidney cancer syndromes". Adv Chronic Kidney Dis. 21 (1): 81–90. doi:10.1053/j.ackd.2013.10.001. PMC 3872053. PMID 24359990.
  2. Linehan WM, Srinivasan R, Schmidt LS (May 2010). "The genetic basis of kidney cancer: a metabolic disease". Nat Rev Urol. 7 (5): 277–85. doi:10.1038/nrurol.2010.47. PMC 2929006. PMID 20448661.
  3. Linehan WM (November 2012). "Genetic basis of kidney cancer: role of genomics for the development of disease-based therapeutics". Genome Res. 22 (11): 2089–100. doi:10.1101/gr.131110.111. PMC 3483538. PMID 23038766.
  4. 4.0 4.1 Cohen HT, McGovern FJ (2005). "Renal-cell carcinoma". N Engl J Med. 353 (23): 2477–90. doi:10.1056/NEJMra043172. PMID 16339096.