Pseudohyperaldosteronism
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Pseudohyperaldosteronism is a condition caused by the chronic excessive ingestion of licorice. Licorice inhibits the 11-beta hydroxysteroid dehydrogenase type II (Protein:HSD11B2) enzyme resulting in inappropriate stimulation of the mineralocorticoid receptor by cortisol.
This condition is characterized by hypertension, kaliuresis and reduced plasma renin.
References
1: Armanini D, Calo L, Semplicini A. Pseudohyperaldosteronism: pathogenetic mechanisms. Crit Rev Clin Lab Sci. Jun;40(3):295-335, 2003
2: Takeuchi K, Abe K, Sato M, Yasujima M, Omata K, Murakami O, Yoshinaga K. Plasma aldosterone level in a female case of pseudohyperaldosteronism (Liddle's syndrome). Endocrinol Jpn. Feb;36(1):167-73, 1989
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Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
