| File:Illustration Glycyrrhiza glabra0.jpg|
| Glycyrrhiza glabra|
Liquorice or licorice (see spelling differences) (IPA: /ˈlɪkərɪʃ, ˈlɪkərɪs, ˈlɪkrɪʃ/, or /ˈlɪkrɪs/) is the root of Glycyrrhiza glabra, from which a sweet flavour can be extracted. The liquorice plant is a legume (related to beans and peas) and native to southern Europe and parts of Asia. It is an herbaceous perennial, growing to 1 m in height, with pinnate leaves about 7–15 centimetres (3–6 inches) long, with 9–17 leaflets. The flowers are 0.8–1.2 cm (1/3 to 1/2 inch) long, purple to pale whitish blue, produced in a loose inflorescence. The fruit is an oblong pod, 2–3 centimetres (about 1 inch) long, containing several seeds.
Cultivation and uses
Liquorice extract is produced by boiling liquorice root and subsequently evaporating most of the water (in fact, the word 'liquorice' is derived from the Ancient Greek words for 'sweet root'). Liquorice extract is traded both in solid and syrup form. Its active principle is glycyrrhizin, a sweetener more than 50 times as sweet as sucrose which also has pharmaceutical effects. G. uralensis contains this chemical in much greater concentration.
Liquorice flavour is found in a wide variety of liquorice candies. The most popular in the United Kingdom are liquorice allsorts. In continental Europe, however, far stronger, saltier candies are preferred. It should be noted, though, that in most of these candies the taste is reinforced by aniseed oil, and the actual content of liquorice is quite low.
Pontefract in Yorkshire was the first place where liquorice mixed with sugar began to be used as a sweet in the same way it is in the modern day. In the Netherlands Liquorice candy is called "Drop" (and it is actually one of the most popular forms of candy), but only a few of the many forms that are sold contain aniseed, although mixing it with mint, menthol or with laurel is popular, and mixing it with Ammonium chloride creates the very popular salty liquorice. 
Liquorice is also found in some soft drinks (such as root beer), and is in some herbal teas where it provides a sweet aftertaste. The flavour is common in medicines to disguise unpleasant flavours. Dutch youth often make their own "Dropwater" (Liquorice water) by putting a few pieces of laurel liquorice and a piece of liquorice root in a bottle with water and then shake it to a frothy liquid, and Dutch youths like to drink a liquorice based liqueur called a "dropshot".
Liquorice is popular in Italy (particularly in the South) and Spain in its natural form. The root of the plant is simply dug up, washed and chewed as mouth-freshener. Throughout Italy unsweetened liquorice is consumed in the form of small black pieces made only from 100% pure liquorice extract; the taste is bitter and intense. In Calabria a popular liqueur is made from pure liquorice extract. Liquorice is also very popular in Syria where it is sold as a drink. Dried liquorice root can be chewed as a sweet. According to the US Department of Agriculture Food Database, black liquorice contains approximately 100 calories per ounce (28g).
Powdered liquorice root is an effective expectorant, and has been used for this purpose since ancient times, especially in Ayurvedic medicine where it is also used in tooth powders. Modern cough syrups often include liquorice extract as an ingredient. Additionally, liquorice may be useful in conventional and naturopathic medicine for both mouth ulcers and peptic ulcers. Non-prescription aphthous ulcer treatment CankerMelts incorporates glycyrrhiza in a dissolving adherent troche. Liquorice is also a mild laxative and may be used as a topical antiviral agent for shingles, ophthalmic, oral or genital herpes.
Liquorice affects the body's endocrine system as it contains isoflavones (phytoestrogens). It can lower the amount of serum testosterone, but whether it affects the amount of free testosterone is unclear. Large doses of glycyrrhizinic acid and glycyrrhetinic acid in liquorice extract can lead to hypokalemia and serious increases in blood pressure, a syndrome known as apparent mineralocorticoid excess. These side effects stem from the inhibition of the enzyme 11β-hydroxysteroid dehydrogenase (type 2) and subsequent increase in activity of cortisol on the kidney. 11β-hydroxysteroid dehydrogenase normally inactivates cortisol in the kidney; thus, liquorice's inhibition of this enzyme makes the concentration of cortisol appear to increase. Cortisol acts at the same receptor as the hormone aldosterone in the kidney and the effects mimic aldosterone excess, although aldosterone remains low or normal during liquorice overdose. To decrease the chances of these serious side effects, deglycyrrhizinated liquorice preparations are available. The disabling of similar enzymes in the gut by glycyrrhizinic acid and glycyrrhetinic acid also causes increased mucus and decreased acid secretion. It inhibits Helicobacter pylori, is used as an aid for healing stomach and duodenal ulcers, and in moderate amounts may soothe an upset stomach. Liquorice can be used to treat ileitis, leaky gut syndrome, irritable bowel syndrome and Crohn's disease as it is antispasmodic in the bowels.
Liquorice is an adaptogen which helps reregulate the Hypothalamic-pituitary-adrenal axis. It can also be used for auto-immune conditions including lupus, scleroderma, rheumatoid arthritis and animal dander allergies.
In traditional Chinese medicine, liquorice is commonly used in herbal formulae to "harmonize" the other ingredients in the formula and to carry the formula into all 12 of the regular meridians and to relieve a spasmodic cough.
In traditional American herbalism it is used in the Hoxsey anti-cancer formula.
Excessive consumption of liquorice or liquorice candy is known to be toxic to the liver and may produce hypokalemia, hypertension  and edema. There have been occasional cases where blood pressure has increased with excessive consumption of liquorice tea, but such occasions are rare and reversible when the herb is withdrawn. Most cases of hypertension from liquorice were caused by eating too much concentrated liquorice candy. Doses as low as 50g daily for two weeks can cause a significant rise in blood pressure.
- Glycyrrhiza glabra (chip of Spanish wood).jpg
Sliver of liquorice root
- Glycyrrhiza glabra (Pile of Spanish wood chips).jpg
Various liqourice root slivers
- "Glycyrrhiza glabra information from NPGS/GRIN". www.ars-grin.gov. Retrieved 2008-03-06.
- Huxley, A., ed. (1992). New RHS Dictionary of Gardening. ISBN 0-333-47494-5
- "Right good food from the Ridings". AboutFood.com. 25 October 2007. Check date values in:
-  Dutch website of Wageningen University with English information about "Drop"
-  semi-official "drop-shot" site (In Dutch)
- Licorice Calories
- عرقسوس (Liquorice)
- Das, S.K. "Deglycyrrhizinated liquorice in aphthous ulcers". The Journal of the Association of Physicians of India. Association of Physicians of India. 37 (10): 647. Unknown parameter
- Krausse, R. (2004). "In vitro anti-Helicobacter pylori activity of Extractum liquiritiae, glycyrrhizin and its metabolites". The Journal of Antimicrobial Chemotherapy. Oxford University Press. 54 (1): 243–246. Unknown parameter
- Materia Medica, retrieved 24 May 2007
- Winston, David (2007). Adaptogens: Herbs for Strength, Stamina, and Stress Relief. Healing Arts Press. Unknown parameter
- Bensky, Dan (2004). Chinese Herbal Medicine: Materia Medica, Third Edition. Eastland Press. ISBN 0939616424. Unknown parameter
- The Nurse's Guide To Herbal Remedies from Salisbury University
- Liquorice and hypertension Editorial in The Netherlands Journal of Medicine, 2005
- A Guide to Medicinal and Aromatic Plants from Purdue University
- Subhuti Dharmananda, Ph.D., Safety Issues Affecting Herbs: Herbs that May Increase Blood Pressue, retrieved 24 May 2007
- Sigurjónsdóttir, H.A., et al. Liquorice-induced rise in blood pressure: a linear dose-response relationship. Journal of Human Hypertension (2001) 15, 549-552.
- Herb Teas and Old Remedies : Liquorice (fr.with translator)
- National Institute of Health - Medline
- PDRhealth.com - Profile of Deglycyrrhizinated Licorice (DGL)
- Chemical & Engineering News article on Licorice
- Non-profit dedicated to promoting licorice
- Offers information and more than 160 licorice products from 13 countries
- Pontefract Liquorice Festival
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