Prokaryotic release factors
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There are three known prokaryotic release factors involved in the termination of translation.
- RF1 recognizes the stop codon UAG
- RF2 recognizes the stop codon UGA (both RF1 and RF2 recognize the stop codon UAA)
- RF3 promotes termination by either factor by accelerating dissociation.
The release factors provide the means of termination by having a conformation that mimics that of tRNA molecules. The decoding release factor binds to the A site of the ribosome and directly recognise the stop codon [1]. Once RF1 (or RF2) and RF3 are bound to the ribosome, the polypeptide is released, and the ribosome and release factors dissasemble, thus completing the process of translation [1].
References
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