Primary amyloidosis MRI

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Shyam Patel [2]; Associate Editor(s)-in-Chief: Sabawoon Mirwais, M.B.B.S, M.D.[3]

Overview

MRI is commonly done to assess for amyloid deposition in particular organs. It can also be done to rule out other causes of organ dysfunction. However, MRI is more sensitive than CT in the diagnosis of amyloidosis. A cardiac MRI is used when an echocardiogram fails to differentiate amyloidosis from hypertrophic cardiomyopathy.

MRI

In cardiac amyloidosis the MRI findings may include[1]:

In hepatic amyloidosis the MRI scan findings may include:

In renal amyloidosis the MRI findings may include:

In amyloidosis involving the peripheral nerves the MRI findings may include:

  • Perineural enhancement

Images

MRI showing cardiac amyloidosis (yellow arrow). [2]
MRI showing hypothalamic amyloidosis (yellow arrows). [3]


References

  1. Falk RH, Quarta CC, Dorbala S (2014). "How to image cardiac amyloidosis". Circ Cardiovasc Imaging. 7 (3): 552–62. doi:10.1161/CIRCIMAGING.113.001396. PMC 4118308. PMID 24847009.
  2. Case courtesy of Dr David Cuevas, <a href="https://radiopaedia.org/">Radiopaedia.org</a>. From the case <a href="https://radiopaedia.org/cases/61600">rID: 61600</a>
  3. Case courtesy of Dr Rebecca Dumont Walter, <a href="https://radiopaedia.org/">Radiopaedia.org</a>. From the case <a href="https://radiopaedia.org/cases/42915">rID: 42915</a>

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