Prilocaine
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| Image:Prilocaine.png | |
| Prilocaine
| |
| Systematic (IUPAC) name | |
| N-(2-methylphenyl)-2-propylamino-propanamide | |
| Identifiers | |
| CAS number | |
| ATC code | N01 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C13H20N2O |
| Mol. mass | 220.311 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Protein binding | 55% |
| Metabolism | Hepatic and renal |
| Half life | 10-150 minutes, longer with impaired hepatic or renal function |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
B (U.S.) |
| Legal status | |
| Routes | ? |
Prilocaine (pronounced /ˈpraɪloʊkeɪn/) is a local anesthetic of the amino amide type. In its injectable form (trade name Citanest), it is often used in dentistry. It is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/prilocaine or EMLA). As it has low cardiac toxicity, it is commoly used for intravenous regional anaesthesia (IVRA).
In some patients, a metabolite of prilocaine may cause the unusual side-effect of methaemoglobinaemia.
Maximum dosage for dental use: 6.0mg/kg (2.7mg/lb), with a maximum dose of 400mg.
de:PrilocainAcknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
