Premarin detailed information
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| Image:Premarin.png | |
| Premarin detailed information
| |
| Systematic (IUPAC) name | |
| sodium 13-methyl-17-oxo-3-sulfonatooxy-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[ a] phenanthrene | |
| Identifiers | |
| CAS number | |
| ATC code | G03 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C18H21NaO5S |
| Mol. mass | 372.412 g/mol |
| SMILES | & |
| Synonyms | conjugated estrogens equilin sulfate |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Protein binding | >90% |
| Metabolism | ? |
| Half life | 7.2 hours |
| Excretion | renal |
| Therapeutic considerations | |
| Pregnancy cat. |
X |
| Legal status |
℞ Prescription only |
| Routes | Oral, topical |
Premarin is the commercial name for compound drug consisting primarily of conjugated estrogens. Isolated from mare's urine (PREgnant MARes' urINe), it is manufactured by Wyeth Pharmaceuticals and has been marketed since 1942. It is available in oral (0.3/ 0.45/ 0.625/ 1.25mg), IV, and topical form.
Pharmacology
The major forms of estrogen in Premarin are estrone (>50%), equilin (15-25%) and equilenin. The estrogens in Premarin are often called "conjugated equine estrogens" (CEE) because the estrogen molecules are generally present with hydrophilic side-groups attached such as sulfate. Thus, estrone sulfate is actually the major molecule in Premarin. Estrone sulfate is easily absorbed into the blood after Premarin pills are taken by women. Estrone sulfate is converted to estradiol, an active estrogen normally found in women. It is not clear if estrogens such as equilin that are foreign to the human body have effects in women that are significantly different from the estrogens like estradiol that are normally made in the human body.
Indications
Premarin is indicated for the treatment of mild to severe vasomotor symptoms of the menopause, prevention of osteoporosis, and treatment of vaginal and vulvar atrophy. Premarin has been one of the most widely used drugs in the United States. Premarin became the form of estrogen most commonly used for hormone replacement therapy.
Controversy
Premarin is the subject of some contention. Animal rights activists claim that animal husbandry and urine collection methods used in Premarin's production cause undue stress and suffering to the mares involved.[1] Additionally, it is proposed that there is an overabundance of poorly bred foals produced by Pregnant Mare Urine (PMU) farms each year. However, PMU horses only represent 0.01% of equines in North America http://www.naeric.org/about_whatis.asp?strOver=11. There has been an increase in the number of registered horses on PMU ranches with almost all horses now being registered stock. http://www.naeric.org/inc/graph3.pdf[] The vast majority of these purebred foals are sold for pleasure riding and driving. http://www.naeric.org/about_faqs.asp
References
See also
External links
- Information page of the manufacturer
- Premarin information at the Food and Drug Administration (FDA) website
- Menopause resource - from Wyeth
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
