Polidocanol

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EC no: 221-284-4

Structure: C₁₂H₂₅O(CH₂CH₂O)~9 H

Formula: C₃₀H₆₂O₁₀

Names: Polidocanol; (also polydocanol); Laureth 9; Macrogol lauryl ether; Lauromacrogols; (mixed macrogols); PEG-9 lauryl alcohol; POE-9 lauryl alcohol; Ethoxylated alcohols; Dodecylnonaoxyethylene glycol monoether; Dodecylpolyethyleneglycolether; Hydroxyl polyethoxy dodecane

Polidocanol is a sclerosant, an irritant injected to treat varicose veins. Polidocanol causes fibrosis inside varicose veins, occluding the lumen of the vessel, and reducing the appearance of the varicosity. It is not approved for use in the US. Current research is involved in development of Polidocanol as a topical therapy, where systemic safety might no longer be an issue. Systemic Polidocanol is sold outside the US under the brand name Aethoxysklerol.

External links

A German producer of Aethoxysklerol:

http://kreussler-pharma.de/index.php?PageID=72

Polidocanol treatment is currently being used inside of the U.S.Template:Polymer-stub

v • d • e Vasoprotectives (C05)
Antihemorrhoidals for topical use	corticosteroids (Hydrocortisone, Prednisolone, Betamethasone, Fluorometholone, Fluocortolone, Dexamethasone, Fluocinolone acetonide, Fluocinonide) - local anesthetics (Lidocaine, Tetracaine, Benzocaine, Cinchocaine, Procaine, Oxetacaine, Pramocaine) - other (Tribenoside)
Antivaricose therapy	heparins or heparinoids for topical use (Organo-heparinoid, Sodium apolate, Heparin, Pentosan polysulfate) - sclerosing agents for local injection (Monoethanolamine oleate, Polidocanol, Invert sugar, Sodium tetradecyl sulfate, Phenol) - Other (Calcium dobesilate)
Capillary stabilising agents	bioflavonoids (Rutoside, Monoxerutin, Diosmin, Troxerutin, Hidrosmin) - other (Tribenoside)