Hypertrichosis
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| Hypertrichosis Classification and external resources | |
| ICD-10 | L68. |
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| ICD-9 | 704.1 |
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Hypertrichosis, congenital generalized Hypertrichosis or werewolf syndrome is a medical term referring to a condition of excessive body hair. It can be generalized, symmetrically affecting most of the torso and limbs, or localized, affecting an area of skin. It may be mild or severe. In most cases, the term is used to refer to an above-average amount of normal body hair that is unwanted and is an aspect of human variability.
In medical practice, once generalized hypertrichosis has been distinguished from hirsutism, it is most often considered a variation of normal, primarily resulting from genetic factors.
Most of the people recently featured in the media with hypertrichosis are from the Aceves clan of Loreto, Zacatecas, Mexico, some of whom have emigrated to the United States. Many of them have worked for circuses. The brothers Victor Ramon "Danny" Ramos and Gabriel "Larry" Ramos have worked as acrobats. Their cousins, Jesus "Chuy" Aceves, and his sister, Lili, have worked in sideshows.
Although the statistic has been cited that this only occurs for 1 out of 10 billion people[3], 19 people alive today have hypertrichosis, out of ~6.5 billion people in the world, makes for an average of 1 in 340 million.
Body hair
 Human hair |
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Nearly all the skin of the human body except palms of hands and soles of feet is covered with hairs. The density of the hairs (in hair follicles per square centimeter) thickness of the hairs, color of the hairs, speed of hair growth, and qualities such as kinkiness, vary from one part of the body to another, and from one person to another. All of these features have strong genetic determinants, as demonstrated by the heritability of these qualities.
Doctors generally distinguish scalp hair, vellus hair, and androgenic (terminal) hair. Scalp hair is the hair on the head. Its absence is termed "baldness." Vellus hair is the hair on the rest of the body which has not been stimulated and transformed by sex hormones. Androgenic hair is the hair that greatly increases in heaviness and rate of growth with puberty.
Vellus hair
Even children are covered with fine vellus hair, varying in density, length, and heaviness, but usually white due to a lack of pigment.
It is evident that a slight genetic variation, or variation in hormone signalling, could turn this vellus hair into full thickness hair. Pigmented thick hairs may grow from a scar, presumably because in the process of growing a scar, the vellus hair follice is triggered into to growing as a thicker pigmented hair follicle.
Also, thick, pigmented hair is noted to grow on the skin near the site of a spinal injury. It is the ordinarily vellus hair follicle responding to a signal even though there is no scar, callous, or other change to the skin.
Duck down
With yet another minor genetic variation, a single hair follicle may start producing a bunch of hairs, which remain in a bundle at the base, but split apart if it grows long enough, and this resembles duck down. This is most common in male facial hair.
Androgenic hair
The hair follicles on much of the body respond to androgens (primarily testosterone and its derivatives). Generally, the rate of hair growth increases and the heaviness of the hairs increases in direct proportion to the androgen levels. However, different areas respond with different sensitivities. As puberty progresses, the sequence of appearance of sexual (androgenic) hair reflects the gradations of androgen sensitivity. The pubic area is most sensitive, and heavier hair usually grows there first in response to androgens. The following regions also respond to androgens, in order of decreasing sensitivity: axillary and perianal areas, sideburns, above the upper lip, periareolar areas, chin and beard areas, arms and legs, chest, shoulders, buttocks, back, and abdomen.
It is the hair in these areas that appears earlier or grows to excess in disorders of excess androgen (e.g., precocious puberty, late-onset congenital adrenal hyperplasia, and polycystic ovary syndrome).
Vellus hair and hypertrichosis
When the unwanted or excessive hair occurs in other places, and especially in other sequences of appearance, it is rarely due to a disorder of androgen excess. For example, it is not unusual for a young girl to be taken to a pediatric endocrinologist because her mother is distressed by the heaviness of the girl's arm and leg hair, but this condition is never due to a disorder of androgen excess if pubic hair has not appeared.
Most hypertrichosis is genetic, but a small number of unusual systemic disorders can sometimes increase vellus hair. Some drugs (e.g., diazoxide, diphenylhydantoin, and minoxidil) and toxins (e.g., mercury) can induce generalized hair growth as well. Unusual hypertrichosis can also be caused by untreated infection, or by malnutrition. For this reason, it is an occasional sign of anorexia nervosa.
Severe hypertrichosis
Severe hypertrichosis is quite rare, almost certainly due to unknown genetic defects, and can result in excessive or animal-like hair on both face and body. Some of these people have been displayed in carnival sideshows with names such as "dog-boy" or the "bearded lady." Fedor Jeftichew, Stephan Bibrowski and Annie Jones are well known examples.
Most of the people recently featured in the media with hypertrichosis are from the Aceves clan of Loreto, Zacatecas, Mexico, some of whom have emigrated to the United States. Many of them have worked for circuses. The brothers Victor Ramon "Danny" Ramos and Gabriel "Larry" Ramos have worked as acrobats. Their cousins, Jesus "Chuy" Aceves, and his sister, Lili, have worked in sideshows.
Localized hypertrichosis
In some cases an area of skin can react to repeated trauma or to some other asymmetric stimulus (such as wearing of a cast) with increased hair growth.
Treatment
In the vast majority of cases, hypertrichosis is a cosmetic problem. The treatments range from camouflage (e.g., bleaching with hydrogen peroxide), to temporary removal by waxing, or permanent removal by electrolysis or laser destruction of hair follicles.
See also
External links
Pictures
Other
- The Wolf People
- Barry Yeoman, When a Woman Goes Bald, Discover
- Close up picture Jesus "Chuy" Fajardo Aceves #1
- Jesus Fajardo Aceves picture #2
- Interview with Jesus "Chuy" Fajardo Aceves
- JoJo the Dog Faced Boy
- Larry and Danny Ramos Gomez, acrobats in the Mexican circus
- Danny featured, along with some relatives, on ABC's Medical Mysteries
- Article on Supatra Sasuphan of Bangkok, Thailand
- "Thailand's one-in-10-billion schoolgirl" by Peter Janssen, "Bangkok Post", retrieved September 13, 2006.
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WikiDoc Research Resources for Hypertrichosis | |
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| Articles on Hypertrichosis | Most recent articles on Hypertrichosis • Most cited articles on Hypertrichosis • Review articles on Hypertrichosis • Articles on Hypertrichosis in N Eng J Med, Lancet, BMJ |
| Media (Slides, Video, Images, MP3) on Hypertrichosis | Powerpoint slides on Hypertrichosis • Images of Hypertrichosis • Photos of Hypertrichosis • Podcasts & MP3s on Hypertrichosis • Videos on Hypertrichosis |
| Evidence Based Medicine Regarding Hypertrichosis | Cochrane Collaboration on Hypertrichosis • Bandolier on Hypertrichosis • TRIP on Hypertrichosis |
| Cost Effectiveness of Hypertrichosis | Cost Effectiveness of Hypertrichosis |
| Clinical Trials Involving Hypertrichosis | Ongoing Trials on Hypertrichosis at Clinical Trials.gov • Trial results on Hypertrichosis • Clinical Trials on Hypertrichosis at Google |
| Guidelines / Policies / Government Resources (FDA/CDC) Regarding Hypertrichosis | US National Guidelines Clearinghouse on Hypertrichosis • NICE Guidance on Hypertrichosis • NHS PRODIGY Guidance • FDA on Hypertrichosis • CDC on Hypertrichosis |
| Textbook Information on Hypertrichosis | Books and Textbook Information on Hypertrichosis |
| Pharmacology Resources on Hypertrichosis | Dosing of Hypertrichosis • Drug interactions with Hypertrichosis • Side effects of Hypertrichosis • Allergic reactions to Hypertrichosis • Overdose information on Hypertrichosis • Carcinogenicity information on Hypertrichosis • Hypertrichosis in pregnancy • Pharmacokinetics of Hypertrichosis • |
| Genetics, Pharmacogenomics, and Proteinomics of Hypertrichosis | Genetics of Hypertrichosis • Pharmacogenomics of Hypertrichosis • Proteomics of Hypertrichosis |
| Newstories on Hypertrichosis | Hypertrichosis in the news • Be alerted to news on Hypertrichosis • News trends on Hypertrichosis |
| Commentary on Hypertrichosis | Blogs on Hypertrichosis |
| Patient Resources on Hypertrichosis | Patient resources on Hypertrichosis • Discussion groups on Hypertrichosis • Patient Handouts on Hypertrichosis • Directions to Hospitals Treating Hypertrichosis • Risk calculators and risk factors for Hypertrichosis |
| Healthcare Provider Resources on Hypertrichosis | Symptoms of Hypertrichosis • Causes & Risk Factors for Hypertrichosis • Diagnostic studies for Hypertrichosis • Treatment of Hypertrichosis |
| Continuing Medical Education (CME) Programs on Hypertrichosis | CME Programs on Hypertrichosis |
| International Resources on Hypertrichosis | Hypertrichosis en Espanol • Hypertrichosis en Francais |
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
