Pneumoconiosis natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Dushka Riaz, MD
Overview
Prognosis is generally poor, and mortality rates vary depending on the specific pneumoconiosis. For example, berylliosis patients mortality rates are between 6 to 35%. [1] [2]
Natural History, Complications, and Prognosis
Natural History
- The symptoms of pneumoconiosis typically develop 10-20 years after exposure to the specific particle, for example, silica in the case of silicosis. [2]
Complications
- Common complications of pneumoconiosis include: [3] [4] [5] [6] [7] [8] [9] [10] [11] [12]
- Pulmonary fibrosis (accelerated by concomitant cigarette smoking)
- Emphysema
- COPD
- Pleural effusion
- Pleural plaques
- Malignant Mesothelioma (Asbestosis)
- Carcinoma
- Tuberculosis
- Scleroderma
- SLE
- Glomerulonephritis
- Pulmonary hypertension
- Cor pulmonale
- Respiratory failure
- Chronic necrotizing aspergillosis (Silicosis)
- Rheumatoid arthritis
- Chronic kidney disease
- Sarcoidosis
- Bronchitis
Prognosis
The prognosis for pneumoconiosis is poor and leads to respiratory complications and premature death. The prognosis is deemed to be poor particularly when fibrosis is found on CT scans. [2] [13] [14] Patients progress quickly to cor pulmonale and respiratory failure. In the case of silicosis, the survival is generally less than four years. [15] [16]
References
- ↑ PEYTON MF, WORCESTER J (1959). "Exposure data and epidemiology of the beryllium case registry, 1958". AMA Arch Ind Health. 19 (2): 94–9. PMID 13616725.
- ↑ 2.0 2.1 2.2 "StatPearls". 2021. PMID 32310362 Check
|pmid=value (help). - ↑ Fujimura N (2000). "Pathology and pathophysiology of pneumoconiosis". Curr Opin Pulm Med. 6 (2): 140–4. doi:10.1097/00063198-200003000-00010. PMID 10741774.
- ↑ Chong S, Lee KS, Chung MJ, Han J, Kwon OJ, Kim TS (2006). "Pneumoconiosis: comparison of imaging and pathologic findings". Radiographics. 26 (1): 59–77. doi:10.1148/rg.261055070. PMID 16418244.
- ↑ Cullinan P, Reid P (2013). "Pneumoconiosis". Prim Care Respir J. 22 (2): 249–52. doi:10.4104/pcrj.2013.00055. PMC 6442808. PMID 23708110.
- ↑ Yew WW, Leung CC, Chang KC, Zhang Y, Chan DP (2019). "Can treatment outcomes of latent TB infection and TB in silicosis be improved?". J Thorac Dis. 11 (1): E8–E10. doi:10.21037/jtd.2018.12.113. PMC 6384370. PMID 30863615.
- ↑ Blanco JJ, Barcala FJ, Moure MA, Mao MC (2011). "[Chronic necrotizing pulmonary aspergillosis as a complication of silicosis]". An Sist Sanit Navar. 34 (1): 109–14. doi:10.4321/s1137-66272011000100013. PMID 21532653.
- ↑ Makol A, Reilly MJ, Rosenman KD (2011). "Prevalence of connective tissue disease in silicosis (1985-2006)-a report from the state of Michigan surveillance system for silicosis". Am J Ind Med. 54 (4): 255–62. doi:10.1002/ajim.20917. PMID 20957678.
- ↑ Zaghi G, Koga F, Nisihara RM, Skare TL, Handar A, Rosa Utiyama SR; et al. (2010). "Autoantibodies in silicosis patients and in silica-exposed individuals". Rheumatol Int. 30 (8): 1071–5. doi:10.1007/s00296-009-1116-z. PMID 19705119.
- ↑ Hertzberg VS, Rosenman KD, Reilly MJ, Rice CH (2002). "Effect of occupational silica exposure on pulmonary function". Chest. 122 (2): 721–8. doi:10.1378/chest.122.2.721. PMID 12171857.
- ↑ Hnizdo E, Vallyathan V (2003). "Chronic obstructive pulmonary disease due to occupational exposure to silica dust: a review of epidemiological and pathological evidence". Occup Environ Med. 60 (4): 237–43. doi:10.1136/oem.60.4.237. PMC 1740506. PMID 12660371.
- ↑ Tron V, Wright JL, Harrison N, Wiggs B, Churg A (1987). "Cigarette smoke makes airway and early parenchymal asbestos-induced lung disease worse in the guinea pig". Am Rev Respir Dis. 136 (2): 271–5. doi:10.1164/ajrccm/136.2.271. PMID 2887135.
- ↑ Sahin H, Brown KK, Curran-Everett D, Hale V, Cool CD, Vourlekis JS; et al. (2007). "Chronic hypersensitivity pneumonitis: CT features comparison with pathologic evidence of fibrosis and survival". Radiology. 244 (2): 591–8. doi:10.1148/radiol.2442060640. PMID 17641377.
- ↑ Walsh SL, Sverzellati N, Devaraj A, Wells AU, Hansell DM (2012). "Chronic hypersensitivity pneumonitis: high resolution computed tomography patterns and pulmonary function indices as prognostic determinants". Eur Radiol. 22 (8): 1672–9. doi:10.1007/s00330-012-2427-0. PMID 22466512.
- ↑ Marchiori E, Ferreira A, Müller NL (2001). "Silicoproteinosis: high-resolution CT and histologic findings". J Thorac Imaging. 16 (2): 127–9. doi:10.1097/00005382-200104000-00012. PMID 11292205.
- ↑ Marchiori E, Souza CA, Barbassa TG, Escuissato DL, Gasparetto EL, Souza AS (2007). "Silicoproteinosis: high-resolution CT findings in 13 patients". AJR Am J Roentgenol. 189 (6): 1402–6. doi:10.2214/AJR.07.2402. PMID 18029877.