Paroxysmal nocturnal hemoglobinuria screening

Jump to navigation Jump to search

Paroxysmal nocturnal hemoglobinuria Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Paroxysmal nocturnal hemoglobinuria from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Paroxysmal nocturnal hemoglobinuria screening On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Paroxysmal nocturnal hemoglobinuria screening

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Paroxysmal nocturnal hemoglobinuria screening

CDC on Paroxysmal nocturnal hemoglobinuria screening

Paroxysmal nocturnal hemoglobinuria screening in the news

Blogs on Paroxysmal nocturnal hemoglobinuria screening

Directions to Hospitals Treating Paroxysmal nocturnal hemoglobinuria

Risk calculators and risk factors for Paroxysmal nocturnal hemoglobinuria screening

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]

Overview

According to the American society of hematology, screening for paroxysmal nocturnal hemolglobinuria is recommended among patients with hemoglobinuria, cytopenia, suspected myelodysplasia, negative direct coombs test intravascular hemolytic anemia, refractory anemia, and aplastic anemia with no apparent sign of intravascular hemolysis.

Screening

  • According to the American society of hematology, screening for paroxysmal nocturnal hemolglobinuria is recommended among patients with:[1]
    • Hemoglobinuria
    • Cytopenia
    • Suspected Myelodysplasia
    • Negative direct coombs test intravascular hemolytic anemia
    • Refractory anemia
    • Aplastic anemia with no apparent sign of intravascular hemolysis
    • Unexplained thrombosis especially in unusual sites as:
      • Budd-Chiari syndrome
      • Other intra-abdominal sites (eg, mesenteric or portal veins)
      • Cerebral veins
      • Dermal veins

References

  1. Parker C, Omine M, Richards S, Nishimura J, Bessler M, Ware R; et al. (2005). "Diagnosis and management of paroxysmal nocturnal hemoglobinuria". Blood. 106 (12): 3699–709. doi:10.1182/blood-2005-04-1717. PMC 1895106. PMID 16051736.

Template:WH Template:WS