Multiple endocrine neoplasia type 2 laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Overview

Laboratory findings consistent with the diagnosis of multiple endocrine neoplasia type 2 include hypercalcemia, hypophosphatemia, elevated parathyroid hormone, and elevated norepinephrine.

Laboratory Findings

• Laboratory findings consistent with the diagnosis of multiple endocrine neoplasia type 2 are tabulated below.

Laboratory findings

Test	Findings
Metabolic	Hypophosphatemia Hypercalcemia Elevated calcitonin Elevated epinephrine Elevated norepinephrine Elevated metanephrine Elevated vanillylmandelic acid Elevated parathyroid hormone Elevated pentagastrin
Urinalysis	Elevated norepinephrine Elevated metanephrine Elevated vanillylmandelic acid
Adapted from Marquard J, Eng C. Multiple Endocrine Neoplasia Type 2. 1999 Sep 27 [Updated 2015 Jun 25]. In: Pagon RA, Adam MP, Ardinger HH, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2015. Available from: http://www.ncbi.nlm.nih.gov/books/NBK1257/

Laboratory tests Normal Range Abnormal value Serum Serum phosphate 2.4 to 4.1 mg/dL <2.4 or >4.1 Serum calcium 8.5-10.2 mg/dL <8.5 or >10.2 mg/dL Serum calcitonin less than 10pg/mL >=100 pg/mL Serum epinephrine less than 30 pg/mL > 30 pg/mL Serum metanephrine less than 30 pg/mL > 30 pg/mL Serum parathyroid hormone 10-65 pg/mL <10 pg/mL or >65 pg/mL Urine Epineprhine 0.5 - 20 mcg/24 hours >20 mcg/24 hours Metaneprhrine 24 - 96 mcg/24 hours > 96 mcg/24 hours Norepinephrine 15 - 80 mcg/24 hours >80 mcg/24 hours Normetanephrine 75 - 375 mcg/24 hours >375 mcg/24 hours Total urine catecholamines 14 - 110 mcg/24 hours >110 mcg/24 hours Total vanillylmandelic acid 2 - 7 milligrams (mg)/24 hours >7 milligrams (mg)/24 hours References ​​​ Template:WikiDoc Sources