Monocytosis

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Monocytosis Classification and external resources
Bone marrow smear from a patient with a 23-month history of CML who developed a slight monocytosis, increased blasts in the blood and marrow, and an increase in marrow eosinophils with abnormal basophilic-staining granules. Cytogenetic studies showed cells with both a t(9;22) and an inv (16) abnormality. (Wright-Giemsa stain). Image courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology
ICD-10	D72.8
ICD-9	288.8
DiseasesDB	22713

WikiDoc Resources for Monocytosis
Articles
Most recent articles on Monocytosis Most cited articles on Monocytosis Review articles on Monocytosis Articles on Monocytosis in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Monocytosis Images of Monocytosis Photos of Monocytosis Podcasts & MP3s on Monocytosis Videos on Monocytosis
Evidence Based Medicine
Cochrane Collaboration on Monocytosis Bandolier on Monocytosis TRIP on Monocytosis
Clinical Trials
Ongoing Trials on Monocytosis at Clinical Trials.gov Trial results on Monocytosis Clinical Trials on Monocytosis at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Monocytosis NICE Guidance on Monocytosis NHS PRODIGY Guidance FDA on Monocytosis CDC on Monocytosis
Books
Books on Monocytosis
News
Monocytosis in the news Be alerted to news on Monocytosis News trends on Monocytosis
Commentary
Blogs on Monocytosis
Definitions
Definitions of Monocytosis
Patient Resources / Community
Patient resources on Monocytosis Discussion groups on Monocytosis Patient Handouts on Monocytosis Directions to Hospitals Treating Monocytosis Risk calculators and risk factors for Monocytosis
Healthcare Provider Resources
Symptoms of Monocytosis Causes & Risk Factors for Monocytosis Diagnostic studies for Monocytosis Treatment of Monocytosis
Continuing Medical Education (CME)
CME Programs on Monocytosis
International
Monocytosis en Espanol Monocytosis en Francais
Businness
Monocytosis in the Marketplace Patents on Monocytosis
Experimental / Informatics
List of terms related to Monocytosis

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Monocytosis is an increase in the number of circulating monocytes. In humans, 950/μL is regarded as at the upper limit of normal; monocyte counts above this level are regarded as monocytosis.

Reference Range
Monocytes	0-0.95 x 10,000/microliters

Differential Diagnosis of Causes of Monocytosis

Infections

• Bacterial Endocarditis
• Brucellosis
• Cytomegalovirus
• Herpes Zoster Virus
• Infectious Endocarditis
• Infectious hepatitis
• Kala-azar
• listeriosis
• Malaria
• Mononeucleosis
• Relapsing fever
• Syphillis
• Tuberculosis
• Trypanosomiasis
• Whooping cough
• Rocky Mountain spotted fever

Hematologic

• Acute lymphocytic leukemia
• Benign familial neutropenia
• Carcinoma
• chronic neutropenia
• Lymphoproliferative disease
• Melodyspastic syndromes
• Myeloproliferative disease
• Other malignant lymphomas
• Recovery from neutropenia

Gastrointestinal

• Cirrhosis
• Ulcerative Colitis

Miscellaneous

• Drugs
• Gaucher's Disease
• Irritable Bowel Syndrome
• Lipid Storage Disease
• Sarcoidosis
• Systemic Lupus Erythematosus
• rheumatoid arthritis
• inflammatory bowel disease

v • d • e Pathology: hematology, myeloid hematologic disease (primarily D50-D77, 280-289)
RBCs/ hemoglobinopathy	+ Polycythemia - Macrocytosis - Anemia Nutritional Iron deficiency anemia (Plummer-Vinson syndrome), Megaloblastic anemia (Pernicious anemia) Hemolytic Hereditary enzyme: G6PD Deficiency - Pyruvate kinase deficiency - Triosephosphate isomerase deficiency hemoglobin: Thalassemia - Sickle-cell disease/trait membrane: Hereditary spherocytosis - Hereditary elliptocytosis - Hereditary stomatocytosis Acquired Autoimmune (Warm, Cold), HUS, MAHA, PNH, PCH, Myelophthisic Aplastic Acquired PRCA, Diamond-Blackfan anemia, Fanconi anemia, Sideroblastic anemia Blood tests Normocytic - Microcytic - Macrocytic - Normochromic - Hypochromic Other Methemoglobinemia
Coagulation/platelets/ coagulopathy/ bleeding diathesis	+ Hypercoagulability primary: Antithrombin III deficiency - Protein C deficiency/Activated protein C resistance/Protein S deficiency/Factor V Leiden - Hyperprothrombinemia acquired: DIC (Congenital afibrinogenemia, Purpura fulminans) - autoimmune (Antiphospholipid) Other Essential thrombocytosis - clotting factor: Hemophilia (A/VIII, B/IX, C/XI) • Von Willebrand disease • Hypoprothrombinemia/II - XIII platelet function: Bernard-Soulier syndrome - Glanzmann's thrombasthenia - Gray platelet syndrome - May Hegglin anomaly - Pelger-Huet anomaly Purpura: Henoch-Schönlein, ITP (Evans syndrome), TTP Thrombocytopenia (Heparin-induced thrombocytopenia)
Monocytes/ macrophages	+ Histiocytosis WHO-I (Langerhans cell histiocytosis) WHO-II/non-Langerhans-cell (Juvenile xanthogranuloma, Hemophagocytic lymphohistiocytosis) WHO-III/malignant (Acute monocytic leukemia, Malignant histiocytosis, Erdheim-Chester disease) Other Chronic granulomatous disease -cytosis: Monocytosis - -penia: Monocytopenia
Granulocytes	+ -cytosis: granulocytosis (Neutrophilia, Eosinophilia, Basophilia) - -penia: Granulocytopenia/agranulocytosis (Neutropenia/Kostmann syndrome, Eosinopenia, Basopenia)
See also hematological malignancy and immune disorders

v • d • e WikiDoc Research Resources for Monocytosis
Articles on Monocytosis	Most recent articles on Monocytosis • Most cited articles on Monocytosis • Review articles on Monocytosis • Articles on Monocytosis in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Monocytosis	Powerpoint slides on Monocytosis • Images of Monocytosis • Photos of Monocytosis • Podcasts & MP3s on Monocytosis • Videos on Monocytosis
Evidence Based Medicine Regarding Monocytosis	Cochrane Collaboration on Monocytosis • Bandolier on Monocytosis • TRIP on Monocytosis
Cost Effectiveness of Monocytosis	Cost Effectiveness of Monocytosis
Clinical Trials Involving Monocytosis	Ongoing Trials on Monocytosis at Clinical Trials.gov • Trial results on Monocytosis • Clinical Trials on Monocytosis at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Monocytosis	US National Guidelines Clearinghouse on Monocytosis • NICE Guidance on Monocytosis • NHS PRODIGY Guidance • FDA on Monocytosis • CDC on Monocytosis
Textbook Information on Monocytosis	Books and Textbook Information on Monocytosis
Pharmacology Resources on Monocytosis	Dosing of Monocytosis • Drug interactions with Monocytosis • Side effects of Monocytosis • Allergic reactions to Monocytosis • Overdose information on Monocytosis • Carcinogenicity information on Monocytosis • Monocytosis in pregnancy • Pharmacokinetics of Monocytosis •
Genetics, Pharmacogenomics, and Proteinomics of Monocytosis	Genetics of Monocytosis • Pharmacogenomics of Monocytosis • Proteomics of Monocytosis
Newstories on Monocytosis	Monocytosis in the news • Be alerted to news on Monocytosis • News trends on Monocytosis
Commentary on Monocytosis	Blogs on Monocytosis
Patient Resources on Monocytosis	Patient resources on Monocytosis • Discussion groups on Monocytosis • Patient Handouts on Monocytosis • Directions to Hospitals Treating Monocytosis • Risk calculators and risk factors for Monocytosis
Healthcare Provider Resources on Monocytosis	Symptoms of Monocytosis • Causes & Risk Factors for Monocytosis • Diagnostic studies for Monocytosis • Treatment of Monocytosis
Continuing Medical Education (CME) Programs on Monocytosis	CME Programs on Monocytosis
International Resources on Monocytosis	Monocytosis en Espanol • Monocytosis en Francais
Business Resources on Monocytosis	Monocytosis in the Marketplace • Patents on Monocytosis
Informatics Resources on Monocytosis	List of terms related to Monocytosis

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .