M2 AML

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M2 AML Classification and external resources
ICD-O:	9874/3

WikiDoc Resources for M2 AML
Articles
Most recent articles on M2 AML Most cited articles on M2 AML Review articles on M2 AML Articles on M2 AML in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on M2 AML Images of M2 AML Photos of M2 AML Podcasts & MP3s on M2 AML Videos on M2 AML
Evidence Based Medicine
Cochrane Collaboration on M2 AML Bandolier on M2 AML TRIP on M2 AML
Clinical Trials
Ongoing Trials on M2 AML at Clinical Trials.gov Trial results on M2 AML Clinical Trials on M2 AML at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on M2 AML NICE Guidance on M2 AML NHS PRODIGY Guidance FDA on M2 AML CDC on M2 AML
Books
Books on M2 AML
News
M2 AML in the news Be alerted to news on M2 AML News trends on M2 AML
Commentary
Blogs on M2 AML
Definitions
Definitions of M2 AML
Patient Resources / Community
Patient resources on M2 AML Discussion groups on M2 AML Patient Handouts on M2 AML Directions to Hospitals Treating M2 AML Risk calculators and risk factors for M2 AML
Healthcare Provider Resources
Symptoms of M2 AML Causes & Risk Factors for M2 AML Diagnostic studies for M2 AML Treatment of M2 AML
Continuing Medical Education (CME)
CME Programs on M2 AML
International
M2 AML en Espanol M2 AML en Francais
Businness
M2 AML in the Marketplace Patents on M2 AML
Experimental / Informatics
List of terms related to M2 AML

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Main article: Acute myeloid leukemia

Overview

M2 is a subtype of AML (Acute Myeloid Leukemia). This subtypeis characterized by a translocation of a part of chromosome 8 to chromosome 21, written as t(8;21). On both sides of the chromosome, now containing pieces from two chromosomes, the DNA codes for different proteins. These two proteins are now being created as one single large protein, with a different effect in the body as the two proteins originally coded by the two different chromosomes. The two different proteins that are fused together are:

• RUNX1
• ETO

References

• Nature Reviews: Cancer

v • d • e Pathology: hematology, myeloid hematologic disease (primarily D50-D77, 280-289)
RBCs/ hemoglobinopathy	+ Polycythemia - Macrocytosis - Anemia Nutritional Iron deficiency anemia (Plummer-Vinson syndrome), Megaloblastic anemia (Pernicious anemia) Hemolytic Hereditary enzyme: G6PD Deficiency - Pyruvate kinase deficiency - Triosephosphate isomerase deficiency hemoglobin: Thalassemia - Sickle-cell disease/trait membrane: Hereditary spherocytosis - Hereditary elliptocytosis - Hereditary stomatocytosis Acquired Autoimmune (Warm, Cold), HUS, MAHA, PNH, PCH, Myelophthisic Aplastic Acquired PRCA, Diamond-Blackfan anemia, Fanconi anemia, Sideroblastic anemia Blood tests Normocytic - Microcytic - Macrocytic - Normochromic - Hypochromic Other Methemoglobinemia
Coagulation/platelets/ coagulopathy/ bleeding diathesis	+ Hypercoagulability primary: Antithrombin III deficiency - Protein C deficiency/Activated protein C resistance/Protein S deficiency/Factor V Leiden - Hyperprothrombinemia acquired: DIC (Congenital afibrinogenemia, Purpura fulminans) - autoimmune (Antiphospholipid) Other Essential thrombocytosis - clotting factor: Hemophilia (A/VIII, B/IX, C/XI) • Von Willebrand disease • Hypoprothrombinemia/II - XIII platelet function: Bernard-Soulier syndrome - Glanzmann's thrombasthenia - Gray platelet syndrome - May Hegglin anomaly - Pelger-Huet anomaly Purpura: Henoch-Schönlein, ITP (Evans syndrome), TTP Thrombocytopenia (Heparin-induced thrombocytopenia)
Monocytes/ macrophages	+ Histiocytosis WHO-I (Langerhans cell histiocytosis) WHO-II/non-Langerhans-cell (Juvenile xanthogranuloma, Hemophagocytic lymphohistiocytosis) WHO-III/malignant (Acute monocytic leukemia, Malignant histiocytosis, Erdheim-Chester disease) Other Chronic granulomatous disease -cytosis: Monocytosis - -penia: Monocytopenia
Granulocytes	+ -cytosis: granulocytosis (Neutrophilia, Eosinophilia, Basophilia) - -penia: Granulocytopenia/agranulocytosis (Neutropenia, Kostmann syndrome)
See also hematological malignancy and immune disorders

v • d • e WikiDoc Research Resources for M2 AML
Articles on M2 AML	Most recent articles on M2 AML • Most cited articles on M2 AML • Review articles on M2 AML • Articles on M2 AML in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on M2 AML	Powerpoint slides on M2 AML • Images of M2 AML • Photos of M2 AML • Podcasts & MP3s on M2 AML • Videos on M2 AML
Evidence Based Medicine Regarding M2 AML	Cochrane Collaboration on M2 AML • Bandolier on M2 AML • TRIP on M2 AML
Cost Effectiveness of M2 AML	Cost Effectiveness of M2 AML
Clinical Trials Involving M2 AML	Ongoing Trials on M2 AML at Clinical Trials.gov • Trial results on M2 AML • Clinical Trials on M2 AML at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding M2 AML	US National Guidelines Clearinghouse on M2 AML • NICE Guidance on M2 AML • NHS PRODIGY Guidance • FDA on M2 AML • CDC on M2 AML
Textbook Information on M2 AML	Books and Textbook Information on M2 AML
Pharmacology Resources on M2 AML	Dosing of M2 AML • Drug interactions with M2 AML • Side effects of M2 AML • Allergic reactions to M2 AML • Overdose information on M2 AML • Carcinogenicity information on M2 AML • M2 AML in pregnancy • Pharmacokinetics of M2 AML •
Genetics, Pharmacogenomics, and Proteinomics of M2 AML	Genetics of M2 AML • Pharmacogenomics of M2 AML • Proteomics of M2 AML
Newstories on M2 AML	M2 AML in the news • Be alerted to news on M2 AML • News trends on M2 AML
Commentary on M2 AML	Blogs on M2 AML
Patient Resources on M2 AML	Patient resources on M2 AML • Discussion groups on M2 AML • Patient Handouts on M2 AML • Directions to Hospitals Treating M2 AML • Risk calculators and risk factors for M2 AML
Healthcare Provider Resources on M2 AML	Symptoms of M2 AML • Causes & Risk Factors for M2 AML • Diagnostic studies for M2 AML • Treatment of M2 AML
Continuing Medical Education (CME) Programs on M2 AML	CME Programs on M2 AML
International Resources on M2 AML	M2 AML en Espanol • M2 AML en Francais
Business Resources on M2 AML	M2 AML in the Marketplace • Patents on M2 AML
Informatics Resources on M2 AML	List of terms related to M2 AML

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