Lysogenic cycle
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Lysogeny, or the lysogenic cycle, is one of two methods of viral reproduction (the lytic cycle is the other). Lysogeny is characterized by the fusion of the nucleic acid of a bacteriophage with that of a host bacterium. The newly integrated genetic material, called a prophage can be transmitted to daughter cells at each subsequent cell division, and a later event (such as UV radiation) can release it, causing proliferation of new phages via the lytic cycle.
Mixed cycles
Following are some types of viruses that replicate by the lysogenic cycle, but also partly by the lytic cycle.
Bacteriophages
Some DNA phages, called temperate phages, only lyse a small fraction of bacterial cells; in the remaining majority of the bacteria, the phage DNA becomes integrated into the bacterial chromosome and replicates along with it. In this lysogenic state, the information contained in the viral nucleic acid is not expressed. The model organism for studying lysogeny is the lambda phage. Roughly 50-60 nucleotides are taken out of the lysogenic pathway and used.
Herpes simplex virus
The Herpes simplex virus first enters the lytic cycle after infecting a human, then the lysogenic cycle before travelling to the nervous system where it resides in the nerve fibers as an episomal element. After a long period of time (months to years) in a latent stage, the herpes virus is often reactivated to the lytic stage, during which it may cause disease symptoms similar to those experienced during the initial infection.
Lysogenic conversion
In some interactions between lysogenic phages and bacteria, lysogenic conversion may occur. It is when a temperate phage induces a change in the phenotype of the bacteria infected that is not part of a usual phage cycle. Changes can often involve the external membrane of the cell by making it impervious to other phages or even by increasing the pathogenic capability of the bacteria for a host.
Examples:
- Corynebacterium diphtheriae produces the toxin of diphtheria only when it is infected by the phage β. In this case, the gene that codes for the toxin is carried by the phage, not the bacteria.
- Vibrio cholerae is a non-toxic strain that can become toxic, producing cholera toxin, when it is infected with the phage CTXφ.
- Clostridium botulinum causes botulism.
- Streptococcus pyogenes causes scarlet fever.
- Shiga toxin
- Tetanus
Extra genes present in prophage genomes which do not have a phage function but (may) act as fitness factors for the lysogen are termed "morons".[1]
References
de:Lysogener Zyklus fr:Lysogénievi:Tiềm tan tg:Лизогения uk:Лізогенія
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .

