Hyperlipidemia classification
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Classification |
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Overview
Hyperlipidemias are classified according to the Fredrickson classification which is based on the pattern of lipoproteins on electrophoresis or ultracentrifugation.[1] It was later adopted by the World Health Organization (WHO). It does not directly account for HDL, and it does not distinguish among the different genes that may be partially responsible for some of these conditions. It remains a popular system of classification, but is considered dated by many.
Classification
| Hyperlipoproteinemia | Synonyms | Problems | Labs description | Treatment |
|---|---|---|---|---|
| Type I | Buerger-Gruetz syndrome, Primary hyperlipoproteinaemia, or Familial hyperchylomicronemia | Decreased lipoprotein lipase (LPL) or altered ApoC2 | Elevated Chylomicrons | Diet Control |
| Type IIa | Polygenic hypercholesterolaemia or Familial hypercholesterolemia | LDL receptor deficiency | Elevated LDL only | Bile Acid Sequestrants, Statins, Niacin |
| Type IIb | Combined hyperlipidemia | Decreased LDL receptor and Increased ApoB | Elevated LDL, VLDL and Triglycerides | Statins, Niacin, Gemfibrozil |
| Type III | Familial Dysbetalipoproteinemia | Defect in ApoE synthesis | Increased IDL | Drug of choice: Gemfibrozil |
| Type IV | Endogenous Hyperlipemia | Increased VLDL production and Decreased elimination | Increased VLDL | Drug of choice: Niacin |
| Type V | Familial Hypertriglyceridemia | Increased VLDL production and Decreased LPL | Increased VLDL and Chylomicrons | Niacin, Gemfibrozil |
Unclassified forms
Non-classified forms are extremely rare:
- Hypo-alpha lipoproteinemia
- Hypo-beta lipoproteinemia (prevalence 0.01-0.1%)
References
- ↑ Frederickson DS, Lee RS. A system for phenotyping hyperlipidemia. Circulation 1965;31:321-7. PMID 14262568.
External links
de:Hyperlipoproteinämiehe:היפרליפידמיהsv:Hyperlipidemi
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