HLA-DR8
| |
| human major histocompatibility complex, class II, DR8
| |
| Haplotypes groups | DQA*01:DRB1*0801 to
DQA*01:DRB1*0806 |
| Structure (See HLA-DR) | |
| Identifiers | alpha *0101
|
| Symbol(s) | HLA-DRA |
| EBI-HLA | DRA*0101 |
| Identifiers | beta 1 *0801 to *0806
|
| Symbol(s) | HLA-DRB1 |
| EBI-HLA | DRB1*0801 |
| EBI-HLA | DRB1*0802 |
| EBI-HLA | DRB1*0803 |
| EBI-HLA | DRB1*0804 |
| EBI-HLA | DRB1*0805 |
| EBI-HLA | DRB1*0806 |
| Shared data | |
| Locus | chr.6 6p21.31 |
HLA-DR8 (DR8) is a HLA-DR serotype that recognizes the DRB1*0801 to *0807, and *0810 to *0812 gene products.
Serology
| DRB1* | DR8 | Sample |
| allele | % | size (N) |
| 0801 | 95 | 1076 |
| 0802 | 96 | 265 |
| 0803 | 88 | 230[2] |
| 0804 | 93 | 186 |
| 0805 | >60 | 5 |
| 0806 | >75 | 13 |
The serological reaction of DR8 is relatively good. The serology of DRB1*0808, *0809 and *0813 to *0832 serotypes is unknown.
Disease associations
DQ8 is linked to papillary thyroid carcinomas [3], early onset pauciarticular juvenile chronic arthritis[4][5], primary biliary cirrhosis[6]
by allele
HLA-DRB1*0801 is linked to primary biliary cirrhosis[7] In Mexicans DR8 is found more often in type-2 juvenile diabetes.[8]
HLA-DRB1*0803 is also linked to primary biliary cirrhosis[7]
Genetic Linkage
| DR8 Haplotypes
| |||
| DRA | DRB1 | ||
|---|---|---|---|
| Haplotypes | *0101 | *0801 | *0101 |
| DQA1 | DQB1 | DRB1 | |
| Haplotypes | *0401 | *0402 | *0801 |
| HLA-A | HLA-B | DRB1 | |
| Haplotypes | *0000 | *0000 | *0801 |
HLA-DR8 is not genetically linked to HLA-DR51 to DR53, but is linked to DQ4 serotypes.
References
- ↑ derived from IMGT/HLA
- ↑ DR12 - 3%
- ↑ Porto T, Coelho I, Boavida J, Pereira C, Nunes J, Mendonça D, Martins B, Sobrinho L, Leite V (2006). "Association of HLA DQ4-DR8 haplotype with papillary thyroid carcinomas.". Clin Endocrinol (Oxf) 64 (2): 179-83. PMID 16430717.
- ↑ Haas J, Truckenbrodt H, Paul C, Hoza J, Scholz S, Albert E. "Subtypes of HLA-DRB1*03, *08, *11, *12, *13 and *14 in early onset pauciarticular juvenile chronic arthritis (EOPA) with and without iridocyclitis.". Clin Exp Rheumatol 12 Suppl 10: S7-14. PMID 7955632.
- ↑ Säilä H, Pitkäniemi J, Tuomilehto J, Savolainen A, Alakulppi N, Tuomilehto-Wolf E, Leirisalo-Repo M, Aho K (2004). "HLA and susceptibility to juvenile idiopathic arthritis: a study of affected sibpairs in an isolated Finnish population.". J Rheumatol 31 (11): 2281-5. PMID 15517645.
- ↑ Underhill J, Donaldson P, Bray G, Doherty D, Portmann B, Williams R (1992). "Susceptibility to primary biliary cirrhosis is associated with the HLA-DR8-DQB1*0402 haplotype.". Hepatology 16 (6): 1404-8. PMID 1359995.
- ↑ 7.0 7.1 Charatcharoenwitthaya P, Lindor K. "Current concepts in the pathogenesis of primary biliary cirrhosis.". Ann Hepatol 4 (3): 161-75. PMID 16177655.
- ↑ Rodríguez-Ventura AL, Yamamoto-Furusho JK, Coyote N, et al (2007). "HLA-DRB1*08 allele may help to distinguish between type 1 diabetes mellitus and type 2 diabetes mellitus in Mexican children". Pediatric diabetes 8 (1): 5-10. doi:10.1111/j.1399-5448.2006.00221.x. PMID 17341285.
HLA DR Serotypes |
|---|
| DR - DR1 - DR2 - DR3 - DR4 - DR5 - DR6 - DR7 - DR8 - DR9 - DR10 - DR11 - DR12 - DR13 - DR14 - DR15 - DR16 - DR17 - DR18 - DR51 - DR52 - DR53 |
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