HLA-DR8

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Illustration of an HLA-DR (Human MHC class II) antigen receptor with bound antigen
human major histocompatibility complex, class II, DR8
Haplotypes groups DQA*01:DRB1*0801 to

DQA*01:DRB1*0806

Structure (See HLA-DR)
Identifiers
alpha *0101
Symbol(s) HLA-DRA
EBI-HLA DRA*0101
Identifiers
beta 1 *0801 to *0806
Symbol(s) HLA-DRB1
EBI-HLA DRB1*0801
EBI-HLA DRB1*0802
EBI-HLA DRB1*0803
EBI-HLA DRB1*0804
EBI-HLA DRB1*0805
EBI-HLA DRB1*0806
Shared data
Locus chr.6 6p21.31

HLA-DR8 (DR8) is a HLA-DR serotype that recognizes the DRB1*0801 to *0807, and *0810 to *0812 gene products.

Serology

DR8 serological recognition of the gene products of some DRB1*08 alleles[1]
DRB1* DR8 Sample
allele % size (N)
0801 95 1076
0802 96 265
0803 88 230[2]
0804 93 186
0805 >60 5
0806 >75 13

The serological reaction of DR8 is relatively good. The serology of DRB1*0808, *0809 and *0813 to *0832 serotypes is unknown.

Disease associations

DQ8 is linked to papillary thyroid carcinomas [3], early onset pauciarticular juvenile chronic arthritis[4][5], primary biliary cirrhosis[6]

by allele

HLA-DRB1*0801 is linked to primary biliary cirrhosis[7] In Mexicans DR8 is found more often in type-2 juvenile diabetes.[8]

HLA-DRB1*0803 is also linked to primary biliary cirrhosis[7]

Genetic Linkage

DR8 Haplotypes
DRA DRB1
Haplotypes *0101 *0801 *0101
DQA1 DQB1 DRB1
Haplotypes *0401 *0402 *0801
HLA-A HLA-B DRB1
Haplotypes *0000 *0000 *0801

HLA-DR8 is not genetically linked to HLA-DR51 to DR53, but is linked to DQ4 serotypes.

References

  1. derived from IMGT/HLA
  2. DR12 - 3%
  3. Porto T, Coelho I, Boavida J, Pereira C, Nunes J, Mendonça D, Martins B, Sobrinho L, Leite V (2006). "Association of HLA DQ4-DR8 haplotype with papillary thyroid carcinomas". Clin Endocrinol (Oxf). 64 (2): 179–83. PMID 16430717.
  4. Haas J, Truckenbrodt H, Paul C, Hoza J, Scholz S, Albert E. "Subtypes of HLA-DRB1*03, *08, *11, *12, *13 and *14 in early onset pauciarticular juvenile chronic arthritis (EOPA) with and without iridocyclitis". Clin Exp Rheumatol. 12 Suppl 10: S7–14. PMID 7955632.
  5. Säilä H, Pitkäniemi J, Tuomilehto J, Savolainen A, Alakulppi N, Tuomilehto-Wolf E, Leirisalo-Repo M, Aho K (2004). "HLA and susceptibility to juvenile idiopathic arthritis: a study of affected sibpairs in an isolated Finnish population". J Rheumatol. 31 (11): 2281–5. PMID 15517645.
  6. Underhill J, Donaldson P, Bray G, Doherty D, Portmann B, Williams R (1992). "Susceptibility to primary biliary cirrhosis is associated with the HLA-DR8-DQB1*0402 haplotype". Hepatology. 16 (6): 1404–8. PMID 1359995.
  7. 7.0 7.1 Charatcharoenwitthaya P, Lindor K. "Current concepts in the pathogenesis of primary biliary cirrhosis". Ann Hepatol. 4 (3): 161–75. PMID 16177655.
  8. Rodríguez-Ventura AL, Yamamoto-Furusho JK, Coyote N; et al. (2007). "HLA-DRB1*08 allele may help to distinguish between type 1 diabetes mellitus and type 2 diabetes mellitus in Mexican children". Pediatric diabetes. 8 (1): 5–10. doi:10.1111/j.1399-5448.2006.00221.x. PMID 17341285.