Gardner's syndrome
You don't need to be Editor-In-Chief to add or edit content to WikiDoc. You can begin to add to or edit text on this WikiDoc page by clicking on the edit button at the top of this page. Next enter or edit the information that you would like to appear here. Once you are done editing, scroll down and click the Save page button at the bottom of the page.
| Gardner's syndrome Classification and external resources | |
 | |
|---|---|
| OMIM | 175100 |
| DiseasesDB | 5094 |
| MedlinePlus | 000266 |
| eMedicine | med/2712 derm/163 |
| MeSH | D005736 |
Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [1] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.
Gardner's syndrome is a genetic disorder characterized by the presence of multiple polyps in the colon together with tumors outside the colon. The extracolonic tumors may include osteomas of the skull, thyroid cancer, epidermoid cysts, fibromas and sebaceous cysts. The countless polyps in the colon predispose to the development of colon cancer.
Inheritance
Gardner's syndrome is inherited in an autosomal dominant manner. Typically, one parent has Gardner's syndrome. Each of their children, male and female alike, are at 50% risk of inheriting the gene for Gardner's syndrome and manifesting it.
Diagnosis
Gardner's syndrome can be identified based on oral findings, including multiple impacted and supernumerary teeth, multiple jaw osteomas which give a "cotton-wool" appearance to the jaws, as well as multiple odontomas, congenital hypertrophy of the retinal pigment epithelium (CHRPE), in addition to multiple adenomatous polyps of the colon.
Eponym
The syndrome is named for Eldon J. Gardner (1909-1989), a college teacher of genetics, who first described it in 1951.[1] Gardner had been introduced to a large Utah family with the syndrome by a premedical student in his course in genetics.
Genetics
Gardner's syndrome is now known to be caused by mutation in the APC gene located in chromosome 5q21 (band q21 on chromosome 5). This is the same gene as is mutant in familial adenomatous polyposis (FAP), a more common disease that also predisposes to colon cancer.
New genetic and molecular information has caused some genetic disorders to be split into multiple entities while other genetic disorders merge into one condition. After existing for most of the second half of the 20th century, Gardner's syndrome has vanished as a separate entity. It has been merged into familial adenomatous polyposis (FAP) and is now considered simply a phenotypic variant of FAP.
References
- ↑ Gardner EJ (1951). "A genetic and clinical study of intestinal polyposis, a predisposing factor for carcinoma of the colon and rectum". Am J Hum Genet. 3: 167–76. PMID 14902760.
External Links
- Gardner's syndrome at NIH's Office of Rare Diseases
WikiDoc Research Resources for Gardner's syndrome | |
|---|---|
| Articles on Gardner's syndrome | Most recent articles on Gardner's syndrome • Most cited articles on Gardner's syndrome • Review articles on Gardner's syndrome • Articles on Gardner's syndrome in N Eng J Med, Lancet, BMJ |
| Media (Slides, Video, Images, MP3) on Gardner's syndrome | Powerpoint slides on Gardner's syndrome • Images of Gardner's syndrome • Photos of Gardner's syndrome • Podcasts & MP3s on Gardner's syndrome • Videos on Gardner's syndrome |
| Evidence Based Medicine Regarding Gardner's syndrome | Cochrane Collaboration on Gardner's syndrome • Bandolier on Gardner's syndrome • TRIP on Gardner's syndrome |
| Cost Effectiveness of Gardner's syndrome | Cost Effectiveness of Gardner's syndrome |
| Clinical Trials Involving Gardner's syndrome | Ongoing Trials on Gardner's syndrome at Clinical Trials.gov • Trial results on Gardner's syndrome • Clinical Trials on Gardner's syndrome at Google |
| Guidelines / Policies / Government Resources (FDA/CDC) Regarding Gardner's syndrome | US National Guidelines Clearinghouse on Gardner's syndrome • NICE Guidance on Gardner's syndrome • NHS PRODIGY Guidance • FDA on Gardner's syndrome • CDC on Gardner's syndrome |
| Textbook Information on Gardner's syndrome | Books and Textbook Information on Gardner's syndrome |
| Pharmacology Resources on Gardner's syndrome | Dosing of Gardner's syndrome • Drug interactions with Gardner's syndrome • Side effects of Gardner's syndrome • Allergic reactions to Gardner's syndrome • Overdose information on Gardner's syndrome • Carcinogenicity information on Gardner's syndrome • Gardner's syndrome in pregnancy • Pharmacokinetics of Gardner's syndrome • |
| Genetics, Pharmacogenomics, and Proteinomics of Gardner's syndrome | Genetics of Gardner's syndrome • Pharmacogenomics of Gardner's syndrome • Proteomics of Gardner's syndrome |
| Newstories on Gardner's syndrome | Gardner's syndrome in the news • Be alerted to news on Gardner's syndrome • News trends on Gardner's syndrome |
| Commentary on Gardner's syndrome | Blogs on Gardner's syndrome |
| Patient Resources on Gardner's syndrome | Patient resources on Gardner's syndrome • Discussion groups on Gardner's syndrome • Patient Handouts on Gardner's syndrome • Directions to Hospitals Treating Gardner's syndrome • Risk calculators and risk factors for Gardner's syndrome |
| Healthcare Provider Resources on Gardner's syndrome | Symptoms of Gardner's syndrome • Causes & Risk Factors for Gardner's syndrome • Diagnostic studies for Gardner's syndrome • Treatment of Gardner's syndrome |
| Continuing Medical Education (CME) Programs on Gardner's syndrome | CME Programs on Gardner's syndrome |
| International Resources on Gardner's syndrome | Gardner's syndrome en Espanol • Gardner's syndrome en Francais |
| Business Resources on Gardner's syndrome | Gardner's syndrome in the Marketplace • Patents on Gardner's syndrome |
| Informatics Resources on Gardner's syndrome | List of terms related to Gardner's syndrome |
| ||||
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
