Gangrene natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Edzel Lorraine Co, D.M.D., M.D.

Overview

Amputation and death are the most common consequence of critical limb ischemia/ chronic limb-threatening ischemia. ^[1] Gas gangrene has a higher fatality rate, ranging from 25% to 100%, if treatment is inadequate or delayed. Increased age, several comorbidities present, and involvement of trunk lead to a poor prognosis. ^[2]

There is a possibility of recurrence of critical limb ischemia/ chronic limb-threatening ischemia.
Follow-up after revascularization procedures is needed for at least two years.^[4]
Gas gangrene has higher fatality rate, ranging from 25% to 100%, if treatment is inadequate or delayed.
Increased age, several comorbidities present, and involvement of trunk lead to a poor prognosis. ^[2]

↑ ^1.0 ^1.1 Elsayed S, Clavijo LC (2015). "Critical limb ischemia". Cardiol Clin. 33 (1): 37–47. doi:10.1016/j.ccl.2014.09.008. PMID 25439329.
↑ ^2.0 ^2.1 Yang Z, Hu J, Qu Y, Sun F, Leng X, Li H; et al. (2015). "Interventions for treating gas gangrene". Cochrane Database Syst Rev (12): CD010577. doi:10.1002/14651858.CD010577.pub2. PMC 8652263 Check |pmc= value (help). PMID 26631369.
↑ Landry GJ (2007). "Functional outcome of critical limb ischemia". J Vasc Surg. 45 Suppl A: A141–8. doi:10.1016/j.jvs.2007.02.052. PMID 17544035.
↑ Conte MS, Bradbury AW, Kolh P, White JV, Dick F, Fitridge R; et al. (2019). "Global vascular guidelines on the management of chronic limb-threatening ischemia". J Vasc Surg. 69 (6S): 3S–125S.e40. doi:10.1016/j.jvs.2019.02.016. PMC 8365864 Check |pmc= value (help). PMID 31159978.