Enoximone
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| Enoximone
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| Systematic (IUPAC) name | |
| 4-methyl-5-(4-methylsulfanylbenzoyl)-1,3- dihydroimidazol-2-one | |
| Identifiers | |
| CAS number | |
| ATC code | C01 |
| PubChem | |
| Chemical data | |
| Formula | C12H12N2O2S |
| Mol. mass | 248.302 g/mol |
| SMILES | & |
| Pharmacokinetic data | |
| Bioavailability | 50% (oral) |
| Protein binding | 85% |
| Metabolism | Hepatic oxidation |
| Half life | 4 to 10 hours |
| Excretion | Renal (60 to 70%) |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | Intravenous |
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Overview
Enoximone (INN, trade name Perfan) is an imidazole phosphodiesterase inhibitor. It is used in the treatment of congestive heart failure.
Selective Phosphodiesterase inhibitors (C01CE, G04BE) | |
|---|---|
| PDE1 | Vinpocetine |
| PDE2 | EHNA |
| PDE3 | Amrinone, Bucladesine, Enoximone, Milrinone |
| PDE4 | Etazolate, HT-0712, Ibudilast, Mesembrine, Rolipram |
| PDE5 | Avanafil, Sildenafil, Tadalafil, Udenafil, Vardenafil |
Cardiac stimulants excluding cardiac glycosides (C01C) | |
|---|---|
| Adrenergic and dopaminergic agents | Etilefrine • Isoprenaline • Norepinephrine • Dopamine • Norfenefrine • Phenylephrine • Dobutamine • Oxedrine • Metaraminol • Methoxamine • Mephentermine • Dimetofrine • Prenalterol • Dopexamine • Gepefrine • Ibopamine • Midodrine • Octopamine • Fenoldopam • Cafedrine • Arbutamine • Theodrenaline • Epinephrine |
| Phosphodiesterase inhibitors (PDE3I) | Amrinone • Milrinone • Enoximone • Bucladesine |
| Other cardiac stimulants | Angiotensinamide • Xamoterol • Levosimendan |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
