Suxamethonium chloride
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| Suxamethonium chloride
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| Systematic (IUPAC) name | |
| 2,2'-[(1,4-dioxobutane-1,4-diyl)bis(oxy)]bis (N,N,N-trimethylethanaminium) | |
| Identifiers | |
| CAS number | |
| ATC code | M03 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C14H30N2O4 |
| Mol. mass | 290.399 g/mol |
| Pharmacokinetic data | |
| Bioavailability | NA |
| Metabolism | By pseudocholinesterase, to succinylmonocholine and choline |
| Half life | ? |
| Excretion | Renal (10%) |
| Therapeutic considerations | |
| Pregnancy cat. | |
| Legal status | |
| Routes | Intravenous |
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Suxamethonium chloride (also known as succinylcholine, scoline, or colloquially as sux) is a medication widely used in emergency medicine and anesthesia to induce muscle relaxation, usually to make endotracheal intubation possible. Suxamethonium is sold under several trade names such as Anectine, and may be referred to as "sux" for short.
Suxamethonium acts as a depolarizing neuromuscular blocker. It imitates the action of acetylcholine at the neuromuscular junction, acting on muscle type nicotinic receptors, but it is not degraded by acetylcholinesterase but by pseudocholinesterase, a plasma cholinesterase. This hydrolysis by pseudocholinesterase is much slower than that of acetylcholine by acetylcholinesterase.
Chemistry
Suxamethonium is a white crystalline substance, it is odourless; solutions have a pH of about 4, the dihydrate melts about 160oC, the anhydrous melts at about 190oC; it is highly soluble in water (1 gram in about 1 mL), soluble in alcohol (1 gram in about 350 mL), slightly soluble in chloroform, and practically insoluble in ether. Suxamethonium is a hygroscopic compound.[1] The compound consists of two acetylcholine molecules that are linked by their acetyl groups.
Effects
There are two phases to the blocking effect of suxamethonium; phase 1 block and phase 2 block, of which the phase 2 block is the principal paralytic effect.
Phase 1 block
The first is due to the prolonged stimulation of the acetylcholine receptor results first in disorganized muscle contractions (fasciculations, considered to be a side effect as mentioned below), as the acetylcholine receptors are stimulated. On stimulation, the acetylcholine receptor becomes a general ion channel, resulting in a high flux of potassium out of the cell, and of sodium into the cell, generating an endplate potential less than the action potential. After this initial firing, the cell enters a refractory period.
Phase 2 block
On continued stimulation, the acetylcholine receptors become desensitised and close. This means that new acetylcholine signals do not cause an action potential; and the continued binding of suxamethonium is ignored. This is the principal paralytic effect of suxamethonium, and wears off as the suxamethonium is degraded, and the acetylcholine receptors return to their normal configuration.
Medical uses
Its medical uses are limited to short-term muscle relaxation in anesthesia and intensive care, usually for facilitation of endotracheal intubation. Despite its many undesired effects on the circulatory system and skeletal muscles (including malignant hyperthermia, a rare but life-threatening disease), it is perennially popular in emergency medicine because it arguably has the fastest onset and shortest duration of action of all muscle relaxants. Both are major points of consideration in the context of trauma care, where paralysis must be induced very quickly and the use of a longer-acting agent might mask the presence of a neurological deficit.
Suxamethonium is quickly degraded by plasma cholinesterase and the duration of effect is usually in the range of a few minutes. When plasma levels of cholinesterase are greatly diminished or an atypical form of cholinesterase is present (an otherwise harmless inherited disorder), paralysis may last much longer.
Side effects
Side effects include fasciculations, muscle pains, acute rhabdomyolysis with hyperkalemia, transient ocular hypertension, constipation[2] and changes in cardiac rhythm including bradycardia, cardiac arrest, and ventricular dysrhythmias. In children with unrecognized neuromuscular diseases, a single injection of suxamethonium can lead to massive release of potassium from skeletal muscles with cardiac arrest.
Suxamethonium does not produce unconsciousness or anesthesia, and its effects may cause considerable psychological distress while simultaneously making it impossible for a patient to communicate. For these reasons, administration of the drug to a conscious patient is strongly contraindicated, except in necessary emergency situations.
Hyperkalemia
The side effect of hyperkalaemia is because the acetylcholine receptor is propped open, allowing continued flow of potassium ions into the extracellular fluid. A typical increase of potassium ion serum concentration on administration of suxamethonium is 0.5 mmol per litre, whereas the normal range of potassium is 3.5 to 5 mmol per litre, i.e. a significant increase.
Hyperkalemia, in turn, results in other side-effects of ventricular fibrillation due to reduced to action potential initiation in the heart.
Death
This drug has occasionally been used as a paralyzing agent for executions by lethal injection, although pancuronium bromide is the preferred agent today because of its longer duration of effect and its absence of fasciculations as a side effect. It has also allegedly been used for murder.[3] For instance, suxamethonium is the drug that is suspected to have been used to murder Nevada State Controller Kathy Augustine.[4]
See also
- Malignant hyperthermia, a rare and fatal side effect of suxamethonium.
- Anesthetics
References
- ↑ Gennaro, Alfonso. Remington: The Science and Practice of Pharmacy, 20th ed. Lippincot, Wiliams and Wilkins, 2000:1336.
- ↑ DiPiro, Joseph, et al. Pharmacotherapy: A Pathophysiologic Approach. 6th ed. McGraw-Hill, 2005:685.
- ↑ i-mass.com : international mass spectrometry web resource. Retrieved on 2007-08-14.
- ↑ Bellisle, Martha. "Chaz Higgs leaves jail", Reno Gazette-Journal, March 27, 2007. Retrieved on 2007-04-02.
External links
Skeletal Muscle relaxants (M03) | |||||||||
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| Peripherally acting (primarily antinicotinic, neuromuscular-blocking drugs) |
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| Centrally Acting |
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| Directly acting | Dantrolene | ||||||||
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
