D-amino acid oxidase

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D-amino-acid oxidase
Identifiers
Symbol	DAO (DAAO)
Entrez	1610
HUGO	2671
OMIM	124050
RefSeq	NM_001917
UniProt	P14920
Other data
EC number	1.4.3.3
Locus	Chr. 12 q24

D-amino acid oxidase (DAAO) is a peroxisomal enzyme containing FAD as cofactor spread from yeasts to human. It is not present in bacteria nor in plants. Its function is to oxidize D-amino acids to the corresponding imino acids producing ammonia and oxygen peroxide. Recently mammalian D-amino acid has been connected to the brain D-serine metabolism and to the regulation of the glutamatergic neurotransmission.

See also

• D-amino acid dehydrogenase
• D-amino acid oxidase activator

External links

• MeSH D-Amino-Acid+Oxidase
• http://www.calzyme.com/commerce/catalog/spcategory.jsp?category_id=1043

References

• Pollegioni L. et al (2007). "Physiological functions of D-amino acid oxidases: from yeast to humans.". Cell Mol Life Sci 64 (11): 1373-94. PMID 17396222.

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