Cirrhosis laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Aditya Govindavarjhulla, M.B.B.S. [2] Sudarshana Datta, MD [3]

Overview

A range of laboratory values may be obtained in the evaluation of cirrhosis, in order to determine disease severity and causation. Liver function tests, complete blood count, basic metabolic panel and coagulation factors are standard in the evaluation of cirrhosis. More specific testing for markers and serum enzymes may be performed when certain etiologies are suspected.

Laboratory Findings

  • Laboratory abnormalities may be the first indication of cirrhosis.

Liver function tests:

Hematologic abnormalities:  [29]

FibroTest

Other laboratory studies performed in newly diagnosed cirrhosis may include:

Combinations of tests

  • Another method is the Lok index[39]
  • A more recent meta-analysis has focused on the diagnosis of cirrhosis among patients with hepatitis C[41] using the Lok index:
    • < 0.2 has negative likelihood ratio of 0.21
    • > 0.6 has positive likelihood ratio of 4.4

References

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