Anaplastic thyroid cancer staging

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Anaplastic thyroid cancer Microchapters


Patient Information


Historical Perspective



Differentiating Anaplastic thyroid cancer from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis



History and Symptoms

Physical Examination

Laboratory Findings

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Echocardiography or Ultrasound

Other Imaging Findings

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Medical Therapy



Cost-Effectiveness of Therapy

Future or Investigational Therapies

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Case #1

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]


According to the American Joint Committee on Cancer (AJCC)[1] there are 4 stages of anaplastic thyroid cancer based on the clinical features and findings on imaging. Each stage is assigned a letter and a number that designate the tumor size, number of lymph node regions involved, and metastasis.


  • No generally accepted staging system is available for anaplastic thyroid cancer. Because the prognosis for anaplastic thyroid cancer is so poor, all anaplastic thyroid cancer are classified as stage IV according to International Union Against Cancer (UICC) staging, regardless of tumor size, nodal status, and either absence or presence of distant metastasis.
  • Undifferentiated (anaplastic) carcinomas are highly malignant cancers of the thyroid. They may be subclassified as small cell or large cell carcinomas. Both grow rapidly and extend to structures beyond the thyroid. Both small cell and large cell carcinomas present as hard, ill-defined masses, often with extension into the structures surrounding the thyroid. Small cell anaplastic thyroid carcinoma must be carefully distinguished from lymphoma. This tumor usually occurs in an older age group and is characterized by extensive local invasion and rapid progression. Five-year survival with this tumor is poor. Death is usually from uncontrolled local cancer in the neck, usually within months of diagnosis.[2]
Anaplastic thyroid cancer
Stage T N M
IVA T4a Any N M0
IVB T4b Any N M1
IVC Any T Any N M1


  1. Stage Information for Thyroid Cancer (2015). Accessed on October, 29 2015
  2. Thyroid Cancer (2015). Accessed on November, 19 2015