Acute basophilic leukemia
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| Acute basophilic leukemia Classification and external resources | |
| ICD-O: | 9870/3 |
|---|---|
| MeSH | D015471 |
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Overview
Acute Basophilic Leukemia is a rare form of acute myeloid leukemia where blasts are accompanied by abnormal basophils in all stages of differentiation. It would most likely be classified as M0 without electron microscopic confirmation of basophil lineage.[1]
Presentation
Differentiated (basophilic granules by light microscopy) and poorly differentiated cases ; Majority are poorly differentiated. MPO negative by light microscopy; granules positive in a speckled pattern by electron microscopy. Myeloid antigens are expressed. Diagnosis of poorly differentiated cases made by electron microscopy. May manifest basophil and mast cell granules by EM. Cytogeneticcally heterogeneous but frequently associated with Philadelphia chromosome. There is no clinically distinguishing features but may be more common in children and young adults and carry a poor prognosis.[1]
References
External link
- http://www.meds.com/leukemia/flow/flow with flow cytometry in AML. Atlas .html
WikiDoc Research Resources for Acute basophilic leukemia | |
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| Articles on Acute basophilic leukemia | Most recent articles on Acute basophilic leukemia • Most cited articles on Acute basophilic leukemia • Review articles on Acute basophilic leukemia • Articles on Acute basophilic leukemia in N Eng J Med, Lancet, BMJ |
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| Evidence Based Medicine Regarding Acute basophilic leukemia | Cochrane Collaboration on Acute basophilic leukemia • Bandolier on Acute basophilic leukemia • TRIP on Acute basophilic leukemia |
| Cost Effectiveness of Acute basophilic leukemia | Cost Effectiveness of Acute basophilic leukemia |
| Clinical Trials Involving Acute basophilic leukemia | Ongoing Trials on Acute basophilic leukemia at Clinical Trials.gov • Trial results on Acute basophilic leukemia • Clinical Trials on Acute basophilic leukemia at Google |
| Guidelines / Policies / Government Resources (FDA/CDC) Regarding Acute basophilic leukemia | US National Guidelines Clearinghouse on Acute basophilic leukemia • NICE Guidance on Acute basophilic leukemia • NHS PRODIGY Guidance • FDA on Acute basophilic leukemia • CDC on Acute basophilic leukemia |
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| Genetics, Pharmacogenomics, and Proteinomics of Acute basophilic leukemia | Genetics of Acute basophilic leukemia • Pharmacogenomics of Acute basophilic leukemia • Proteomics of Acute basophilic leukemia |
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
