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*{{cite journal |vauthors=Hirano S, Yamada K, Kawata H, etal |title=Rat zinc-fingers and homeoboxes 1 (ZHX1), a nuclear factor-YA-interacting nuclear protein, forms a homodimer. |journal=Gene |volume=290 |issue= 1–2 |pages= 107–14 |year= 2002 |pmid= 12062805 |doi=10.1016/S0378-1119(02)00553-X }} | *{{cite journal |vauthors=Hirano S, Yamada K, Kawata H, etal |title=Rat zinc-fingers and homeoboxes 1 (ZHX1), a nuclear factor-YA-interacting nuclear protein, forms a homodimer. |journal=Gene |volume=290 |issue= 1–2 |pages= 107–14 |year= 2002 |pmid= 12062805 |doi=10.1016/S0378-1119(02)00553-X }} | ||
*{{cite journal |vauthors=Yamada K, Kawata H, Matsuura K, etal |title=Functional analysis and the molecular dissection of zinc-fingers and homeoboxes 1 (ZHX1). |journal=Biochem. Biophys. Res. Commun. |volume=297 |issue= 2 |pages= 368–74 |year= 2002 |pmid= 12237128 |doi=10.1016/S0006-291X(02)02203-9 }} | *{{cite journal |vauthors=Yamada K, Kawata H, Matsuura K, etal |title=Functional analysis and the molecular dissection of zinc-fingers and homeoboxes 1 (ZHX1). |journal=Biochem. Biophys. Res. Commun. |volume=297 |issue= 2 |pages= 368–74 |year= 2002 |pmid= 12237128 |doi=10.1016/S0006-291X(02)02203-9 }} | ||
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }} | ||
*{{cite journal |vauthors=Yamada K, Kawata H, Shou Z, etal |title=Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3. |journal=Biochem. J. |volume=373 |issue= Pt 1 |pages= 167–78 |year= 2003 |pmid= 12659632 |doi= 10.1042/BJ20021866 | pmc=1223464 }} | *{{cite journal |vauthors=Yamada K, Kawata H, Shou Z, etal |title=Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3. |journal=Biochem. J. |volume=373 |issue= Pt 1 |pages= 167–78 |year= 2003 |pmid= 12659632 |doi= 10.1042/BJ20021866 | pmc=1223464 }} | ||
*{{cite journal |vauthors=Kawata H, Yamada K, Shou Z, etal |title=Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor. |journal=Biochem. J. |volume=373 |issue= Pt 3 |pages= 747–57 |year= 2003 |pmid= 12741956 |doi= 10.1042/BJ20030171 | pmc=1223552 }} | *{{cite journal |vauthors=Kawata H, Yamada K, Shou Z, etal |title=Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor. |journal=Biochem. J. |volume=373 |issue= Pt 3 |pages= 747–57 |year= 2003 |pmid= 12741956 |doi= 10.1042/BJ20030171 | pmc=1223552 }} | ||
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*{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }} | *{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }} | ||
*{{cite journal |vauthors=Brandenberger R, Wei H, Zhang S, etal |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }} | *{{cite journal |vauthors=Brandenberger R, Wei H, Zhang S, etal |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }} | ||
*{{cite journal |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 }} | *{{cite journal |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |bibcode=2004PNAS..10112130B }} | ||
*{{cite journal |vauthors=Goehler H, Lalowski M, Stelzl U, etal |title=A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. |journal=Mol. Cell |volume=15 |issue= 6 |pages= 853–65 |year= 2004 |pmid= 15383276 |doi= 10.1016/j.molcel.2004.09.016 }} | *{{cite journal |vauthors=Goehler H, Lalowski M, Stelzl U, etal |title=A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. |journal=Mol. Cell |volume=15 |issue= 6 |pages= 853–65 |year= 2004 |pmid= 15383276 |doi= 10.1016/j.molcel.2004.09.016 }} | ||
*{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | ||
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Zinc fingers and homeoboxes protein 1 is a protein that in humans is encoded by the ZHX1 gene.[1][2]
The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 1 of this gene family. In addition to forming homodimers, this protein heterodimerizes with members 2 and 3 of the zinc fingers and homeoboxes family. Alternative splicing results in multiple transcript variants encoding the same protein.[2]
Interactions
ZHX1 has been shown to interact with NFYA.[1][3]
References
- ↑ 1.0 1.1 Yamada K, Printz RL, Osawa H, Granner DK (Sep 1999). "Human ZHX1: cloning, chromosomal location, and interaction with transcription factor NF-Y". Biochem Biophys Res Commun. 261 (3): 614–21. doi:10.1006/bbrc.1999.1087. PMID 10441475.
- ↑ 2.0 2.1 "Entrez Gene: ZHX1 zinc fingers and homeoboxes 1".
- ↑ Yamada, K; Osawa H; Granner D K (Oct 1999). "Identification of proteins that interact with NF-YA". FEBS Lett. NETHERLANDS. 460 (1): 41–5. doi:10.1016/S0014-5793(99)01311-3. ISSN 0014-5793. PMID 10571058.
Further reading
- Yamada K, Osawa H, Granner DK (1999). "Identification of proteins that interact with NF-YA". FEBS Lett. 460 (1): 41–5. doi:10.1016/S0014-5793(99)01311-3. PMID 10571058.
- Hirano S, Yamada K, Kawata H, et al. (2002). "Rat zinc-fingers and homeoboxes 1 (ZHX1), a nuclear factor-YA-interacting nuclear protein, forms a homodimer". Gene. 290 (1–2): 107–14. doi:10.1016/S0378-1119(02)00553-X. PMID 12062805.
- Yamada K, Kawata H, Matsuura K, et al. (2002). "Functional analysis and the molecular dissection of zinc-fingers and homeoboxes 1 (ZHX1)". Biochem. Biophys. Res. Commun. 297 (2): 368–74. doi:10.1016/S0006-291X(02)02203-9. PMID 12237128.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Yamada K, Kawata H, Shou Z, et al. (2003). "Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3". Biochem. J. 373 (Pt 1): 167–78. doi:10.1042/BJ20021866. PMC 1223464. PMID 12659632.
- Kawata H, Yamada K, Shou Z, et al. (2003). "Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor". Biochem. J. 373 (Pt 3): 747–57. doi:10.1042/BJ20030171. PMC 1223552. PMID 12741956.
- Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–65. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
- Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
- Liu G, Clement LC, Kanwar YS, et al. (2007). "ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome". J. Biol. Chem. 281 (51): 39681–92. doi:10.1074/jbc.M606664200. PMID 17056598.
- Kim SH, Park J, Choi MC, et al. (2007). "Zinc-fingers and homeoboxes 1 (ZHX1) binds DNA methyltransferase (DNMT) 3B to enhance DNMT3B-mediated transcriptional repression". Biochem. Biophys. Res. Commun. 355 (2): 318–23. doi:10.1016/j.bbrc.2007.01.187. PMID 17303076.
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