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'''Zinc fingers and homeoboxes protein 1''' is a [[protein]] that in humans is encoded by the ''ZHX1'' [[gene]].<ref name="pmid10441475">{{cite journal |vauthors=Yamada K, Printz RL, Osawa H, Granner DK | title = Human ZHX1: cloning, chromosomal location, and interaction with transcription factor NF-Y | journal = Biochem Biophys Res Commun | volume = 261 | issue = 3 | pages = 614–21 |date=Sep 1999 | pmid = 10441475 | pmc =  | doi = 10.1006/bbrc.1999.1087 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ZHX1 zinc fingers and homeoboxes 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11244| accessdate = }}</ref>
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| image = PBB_Protein_ZHX1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2ecb.
| PDB = {{PDB2|2ecb}}, {{PDB2|2ghf}}
| Name = Zinc fingers and homeoboxes 1
| HGNCid = 12871
| Symbol = ZHX1
| AltSymbols =;
| OMIM = 604764
| ECnumber = 
| Homologene = 5225
| MGIid = 109271
| GeneAtlas_image1 = PBB_GE_ZHX1_gnf1h00108_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
  | Process = {{GNF_GO|id=GO:0045892 |text = negative regulation of transcription, DNA-dependent}}  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 11244
    | Hs_Ensembl = ENSG00000165156
    | Hs_RefseqProtein = NP_001017926
    | Hs_RefseqmRNA = NM_001017926
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 124329878
    | Hs_GenLoc_end = 124355728
    | Hs_Uniprot = Q9UKY1
    | Mm_EntrezGene = 22770
    | Mm_Ensembl = ENSMUSG00000022361
    | Mm_RefseqmRNA = NM_001042438
    | Mm_RefseqProtein = NP_001035903
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 57877389
    | Mm_GenLoc_end = 57906552
    | Mm_Uniprot = Q5DTL2
  }}
}}
'''Zinc fingers and homeoboxes 1''', also known as '''ZHX1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ZHX1 zinc fingers and homeoboxes 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11244| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 1 of this gene family. In addition to forming homodimers, this protein heterodimerizes with members 2 and 3 of the zinc fingers and homeoboxes family. Alternative splicing results in multiple transcript variants encoding the same protein.<ref name="entrez">{{cite web | title = Entrez Gene: ZHX1 zinc fingers and homeoboxes 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11244| accessdate = }}</ref>
| summary_text = The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 1 of this gene family. In addition to forming homodimers, this protein heterodimerizes with members 2 and 3 of the zinc fingers and homeoboxes family. Alternative splicing results in multiple transcript variants encoding the same protein.<ref name="entrez">{{cite web | title = Entrez Gene: ZHX1 zinc fingers and homeoboxes 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11244| accessdate = }}</ref>
}}
}}
==Interactions==
ZHX1 has been shown to [[Protein-protein interaction|interact]] with [[NFYA]].<ref name=pmid10441475 /><ref name=pmid10571058>{{cite journal |doi=10.1016/S0014-5793(99)01311-3 |last=Yamada |first=K |authorlink= |author2=Osawa H |author3=Granner D K  |date=Oct 1999 |title=Identification of proteins that interact with NF-YA |journal=FEBS Lett. |volume=460 |issue=1 |pages=41–5 |publisher= |location = NETHERLANDS| issn = 0014-5793| pmid = 10571058 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Yamada K, Printz RL, Osawa H, Granner DK |title=Human ZHX1: cloning, chromosomal location, and interaction with transcription factor NF-Y. |journal=Biochem. Biophys. Res. Commun. |volume=261 |issue= 3 |pages= 614-21 |year= 1999 |pmid= 10441475 |doi= 10.1006/bbrc.1999.1087 }}
*{{cite journal  |vauthors=Yamada K, Osawa H, Granner DK |title=Identification of proteins that interact with NF-YA. |journal=FEBS Lett. |volume=460 |issue= 1 |pages= 41–5 |year= 1999 |pmid= 10571058 |doi=10.1016/S0014-5793(99)01311-3 }}
*{{cite journal  | author=Yamada K, Osawa H, Granner DK |title=Identification of proteins that interact with NF-YA. |journal=FEBS Lett. |volume=460 |issue= 1 |pages= 41-5 |year= 1999 |pmid= 10571058 |doi=  }}
*{{cite journal   |vauthors=Hirano S, Yamada K, Kawata H, etal |title=Rat zinc-fingers and homeoboxes 1 (ZHX1), a nuclear factor-YA-interacting nuclear protein, forms a homodimer. |journal=Gene |volume=290 |issue= 1–2 |pages= 107–14 |year= 2002 |pmid= 12062805 |doi=10.1016/S0378-1119(02)00553-X }}
*{{cite journal | author=Hirano S, Yamada K, Kawata H, ''et al.'' |title=Rat zinc-fingers and homeoboxes 1 (ZHX1), a nuclear factor-YA-interacting nuclear protein, forms a homodimer. |journal=Gene |volume=290 |issue= 1-2 |pages= 107-14 |year= 2002 |pmid= 12062805 |doi=  }}
*{{cite journal   |vauthors=Yamada K, Kawata H, Matsuura K, etal |title=Functional analysis and the molecular dissection of zinc-fingers and homeoboxes 1 (ZHX1). |journal=Biochem. Biophys. Res. Commun. |volume=297 |issue= 2 |pages= 368–74 |year= 2002 |pmid= 12237128 |doi=10.1016/S0006-291X(02)02203-9 }}
*{{cite journal | author=Yamada K, Kawata H, Matsuura K, ''et al.'' |title=Functional analysis and the molecular dissection of zinc-fingers and homeoboxes 1 (ZHX1). |journal=Biochem. Biophys. Res. Commun. |volume=297 |issue= 2 |pages= 368-74 |year= 2002 |pmid= 12237128 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Yamada K, Kawata H, Shou Z, etal |title=Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3. |journal=Biochem. J. |volume=373 |issue= Pt 1 |pages= 167–78 |year= 2003 |pmid= 12659632 |doi= 10.1042/BJ20021866 | pmc=1223464 }}
*{{cite journal | author=Yamada K, Kawata H, Shou Z, ''et al.'' |title=Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3. |journal=Biochem. J. |volume=373 |issue= Pt 1 |pages= 167-78 |year= 2003 |pmid= 12659632 |doi= 10.1042/BJ20021866 }}
*{{cite journal   |vauthors=Kawata H, Yamada K, Shou Z, etal |title=Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor. |journal=Biochem. J. |volume=373 |issue= Pt 3 |pages= 747–57 |year= 2003 |pmid= 12741956 |doi= 10.1042/BJ20030171 | pmc=1223552 }}
*{{cite journal | author=Kawata H, Yamada K, Shou Z, ''et al.'' |title=Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor. |journal=Biochem. J. |volume=373 |issue= Pt 3 |pages= 747-57 |year= 2003 |pmid= 12741956 |doi= 10.1042/BJ20030171 }}
*{{cite journal   |vauthors=Lehner B, Semple JI, Brown SE, etal |title=Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. |journal=Genomics |volume=83 |issue= 1 |pages= 153–67 |year= 2004 |pmid= 14667819 |doi=10.1016/S0888-7543(03)00235-0 }}
*{{cite journal | author=Lehner B, Semple JI, Brown SE, ''et al.'' |title=Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. |journal=Genomics |volume=83 |issue= 1 |pages= 153-67 |year= 2004 |pmid= 14667819 |doi=  }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Brandenberger R, Wei H, Zhang S, etal |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{cite journal | author=Brandenberger R, Wei H, Zhang S, ''et al.'' |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707-16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{cite journal   |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal   |vauthors=Goehler H, Lalowski M, Stelzl U, etal |title=A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. |journal=Mol. Cell |volume=15 |issue= 6 |pages= 853–65 |year= 2004 |pmid= 15383276 |doi= 10.1016/j.molcel.2004.09.016 }}
*{{cite journal | author=Goehler H, Lalowski M, Stelzl U, ''et al.'' |title=A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. |journal=Mol. Cell |volume=15 |issue= 6 |pages= 853-65 |year= 2004 |pmid= 15383276 |doi= 10.1016/j.molcel.2004.09.016 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Stelzl U, Worm U, Lalowski M, etal |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
*{{cite journal | author=Stelzl U, Worm U, Lalowski M, ''et al.'' |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957-68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
*{{cite journal   |vauthors=Lim J, Hao T, Shaw C, etal |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal   |vauthors=Liu G, Clement LC, Kanwar YS, etal |title=ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome. |journal=J. Biol. Chem. |volume=281 |issue= 51 |pages= 39681–92 |year= 2007 |pmid= 17056598 |doi= 10.1074/jbc.M606664200 }}
*{{cite journal | author=Liu G, Clement LC, Kanwar YS, ''et al.'' |title=ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome. |journal=J. Biol. Chem. |volume=281 |issue= 51 |pages= 39681-92 |year= 2007 |pmid= 17056598 |doi= 10.1074/jbc.M606664200 }}
*{{cite journal   |vauthors=Kim SH, Park J, Choi MC, etal |title=Zinc-fingers and homeoboxes 1 (ZHX1) binds DNA methyltransferase (DNMT) 3B to enhance DNMT3B-mediated transcriptional repression. |journal=Biochem. Biophys. Res. Commun. |volume=355 |issue= 2 |pages= 318–23 |year= 2007 |pmid= 17303076 |doi= 10.1016/j.bbrc.2007.01.187 }}
*{{cite journal | author=Kim SH, Park J, Choi MC, ''et al.'' |title=Zinc-fingers and homeoboxes 1 (ZHX1) binds DNA methyltransferase (DNMT) 3B to enhance DNMT3B-mediated transcriptional repression. |journal=Biochem. Biophys. Res. Commun. |volume=355 |issue= 2 |pages= 318-23 |year= 2007 |pmid= 17303076 |doi= 10.1016/j.bbrc.2007.01.187 }}
}}
}}
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{{refend}}
{{PDB Gallery|geneid=11244}}
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Revision as of 01:08, 19 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Zinc fingers and homeoboxes protein 1 is a protein that in humans is encoded by the ZHX1 gene.[1][2]

The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 1 of this gene family. In addition to forming homodimers, this protein heterodimerizes with members 2 and 3 of the zinc fingers and homeoboxes family. Alternative splicing results in multiple transcript variants encoding the same protein.[2]

Interactions

ZHX1 has been shown to interact with NFYA.[1][3]

References

  1. ↑ 1.0 1.1 Yamada K, Printz RL, Osawa H, Granner DK (Sep 1999). "Human ZHX1: cloning, chromosomal location, and interaction with transcription factor NF-Y". Biochem Biophys Res Commun. 261 (3): 614–21. doi:10.1006/bbrc.1999.1087. PMID 10441475.
  2. ↑ 2.0 2.1 "Entrez Gene: ZHX1 zinc fingers and homeoboxes 1".
  3. ↑ Yamada, K; Osawa H; Granner D K (Oct 1999). "Identification of proteins that interact with NF-YA". FEBS Lett. NETHERLANDS. 460 (1): 41–5. doi:10.1016/S0014-5793(99)01311-3. ISSN 0014-5793. PMID 10571058.

Further reading



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