Wheeze differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: John Fani Srour, M.D.

Differentiating Wheeze from other Diseases

Overview

The differential diagnosis of wheezing is wide, and the cause of wheezing in a given patient is determined by considering the characteristics of the wheezes and the historical and clinical findings made by the examining physician.

Complete Differential Diagnosis of the Causes of Wheeze

(In alphabetical order)

Complete Differential Diagnosis of the Causes of Wheeze

(By organ system)

Cardiovascular Cardiac asthma ( pulmonary edema), Cardiomegaly, Descending aortic aneurysm, Pulmonary edema

Pulmonary embolism, Right sided aortic arch, Vascular compression/ rings, Heart failure

Chemical / poisoning Dialyzer hypersensitivity syndrome, Food allergies, Peanut Allergy, Chemical poisoning
Dermatologic No underlying causes
Drug Side Effect Medication-induced bronchoconstriction, ACE inhibitors, Sotalol

,Adenosine, Beta blockers, Dipyridamole, Protamine, NSAIDs, Aspirin, Marijuana

Ear Nose Throat Aspiration(foreign particles or foods), Bilateral vocal cord paralysis, Hypertrophied tonsils, Intrathoracic goiter, Laryngeal edema, Laryngocele, Laryngostenosis, Laryngotracheobronchitis, Mobile supraglottic soft tissue, Paroxysmal vocal cord motion, Postextubation granuloma, Postlobectomy bronchial torsion, Postnasal drip syndrome, Postradiation stenosis, Retropharyngeal abscess, Supraglottitis, Vocal cord dysfunction, Vocal cord hematoma, Sinusitis
Endocrine Intrathoracic goiter, Obesity,
Environmental asthma, Byssinosis, Hay fever
Gastroenterologic Gastroesophageal Reflux Disease
Genetic Cystic fibrosis, Milk allergy, Obesity, Primary ciliary dyskinesia, Vascular compression/ rings, Alpha 1-Antitrypsin Deficiency, Ciliary dyskinesia-bronchiectasis,
Hematologic Lymphadenopathy
Iatrogenic Aspiration(foreign particles or foods), Esophageal foreign body, Mendelson's syndrome (aspiration pneumonitis),
Infectious Disease Allergic bronchopulmonary aspergillosis, Cold induced wheezing, Bronchitis, Bronchiolitis, pneumonia, Lymphadenopathy, Retropharyngeal abscess, Tuberculosis, Ascariasis, Hookworm, Paragonimiases - lung infection, Strongyloidiasis, Toxocariasis, Aspergillosis
Musculoskeletal / Ortho Cricoarytenoid arthritis,
Neurologic No underlying causes
Nutritional / Metabolic Obesity
Obstetric/Gynecologic No underlying causes
Oncologic Carcinoid syndrome, Lymphadenopathy, Lymphangitic carcinomatosis, Malignancy (bronchogenic tumors), Bronchial adenomata syndrome, Mastocytosis
Opthalmologic No underlying causes
Overdose / Toxicity chemical poisoning
Psychiatric Psychogenic wheezing
Pulmonary Bronchiectasis, Bronchiolitis, Bronchiolitis obliterans, Bronchitis, Bronchopulmonary dysplasia, Carcinoid syndrome, Chronic obstructive pulmonary disease: Chronic bronchitis and Emphysema, Cold induced wheezing, Cystic fibrosis, Pulmonary hemorrhage, pneumonia, Interstitial lung disease, Postlobectomy bronchial torsion, Postradiation stenosis, Primary ciliary dyskinesia, Pulmonary edema, Pulmonary embolism, Tracheal stenosis, Tracheobronchitis, Tracheobronchomegaly, Tracheomalacia, Wegener's granulomatosis, Pulmonary eosinophilia, Tuberculosis, Alpha 1-Antitrypsin Deficiency, Extrinsic allergic alveolitis, Bronchial adenomata syndrome, Ciliary dyskinesia-bronchiectasis, Tracheobronchopathia osteoplastica, Aspergillosis
Renal / Electrolyte No underlying causes
Rheum / Immune / Allergy Allergic bronchopulmonary aspergillosis, Anaphylaxis, Angioedema, Asthma, Cricoarytenoid arthritis, Immunodeficiency, Interstitial lung disease, Lymphadenopathy, Milk allergy, Relapsing polychondritis, Wegener's granulomatosis, Pulmonary eosinophilia, Extrinsic allergic alveolitis, Graft-versus-host disease, Hay fever, Mastocytosis,
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous Amyloid deposition, Tracheobronchopathia osteochondroplastica
Inflamed airways and bronchoconstriction in asthma. Airways narrowed as a result of the inflammatory response cause wheezing.