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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''NEDD4-liثثبقثke E3 ubiquitin-protein ligase WWP2''' also known as '''atrophin-1-interacting protein 2''' (AIP2) or '''WW domain-containing protein 2''' (WWP2) is an [[enzyme]] that in humans is encoded by the ''WWP2'' [[gene]].<ref name="pmid9169421">{{cite journal | vauthors = Pirozzi G, McConnell SJ, Uveges AJ, Carter JM, Sparks AB, Kay BK, Fowlkes DM | title = Identification of novel human WW domain-containing proteins by cloning of ligand targets | journal = J Biol Chem | volume = 272 | issue = 23 | pages = 14611–6 | date = Jun 1997 | pmid = 9169421 | pmc =  | doi = 10.1074/jbc.272.23.14611 }}</ref><ref name="pmid12167593">{{cite journal | vauthors = McDonald FJ, Western AH, McNeil JD, Thomas BC, Olson DR, Snyder PM | title = Ubiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na(+) channel | journal = Am J Physiol Renal Physiol | volume = 283 | issue = 3 | pages = F431–6 | date = Aug 2002 | pmid = 12167593 | pmc = | doi = 10.1152/ajprenal.00080.2002 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: WWP2 WW domain containing E3 ubiquitin protein ligase 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11060| accessdate = }}</ref>
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = WW domain containing E3 ubiquitin protein ligase 2
| HGNCid = 16804
| Symbol = WWP2
| AltSymbols =; AIP2; WWp2-like
| OMIM = 602308
| ECnumber = 
| Homologene = 48490
| MGIid = 1914144
| Function = {{GNF_GO|id=GO:0004842 |text = ubiquitin-protein ligase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016874 |text = ligase activity}}
| Component = {{GNF_GO|id=GO:0000151 |text = ubiquitin ligase complex}} {{GNF_GO|id=GO:0005622 |text = intracellular}}
| Process = {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}} {{GNF_GO|id=GO:0046718 |text = entry of virus into host cell}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 11060
    | Hs_Ensembl = ENSG00000198373
    | Hs_RefseqProtein = NP_008945
    | Hs_RefseqmRNA = NM_007014
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 68353749
    | Hs_GenLoc_end = 68533144
    | Hs_Uniprot = O00308
    | Mm_EntrezGene = 66894
    | Mm_Ensembl = ENSMUSG00000031930
    | Mm_RefseqmRNA = NM_025830
    | Mm_RefseqProtein = NP_080106
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 110325527
    | Mm_GenLoc_end = 110447724
    | Mm_Uniprot = Q3TXI7
  }}
}}
'''WW domain containing E3 ubiquitin protein ligase 2''', also known as '''WWP2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: WWP2 WW domain containing E3 ubiquitin protein ligase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11060| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of the NEDD4-like protein family. The family of proteins is known to possess [[ubiquitin ligase|ubiquitin-protein ligase]] activity. The encoded protein contains 4 tandem [[WW domain]]s. The WW domain is a protein motif consisting of 35 to 40 amino acids and is characterized by 4 conserved aromatic residues. The WW domain may mediate specific protein–protein interactions. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the NEDD4-like protein family. The family of proteins is known to possess ubiquitin-protein ligase activity. The encoded protein contains 4 tandem WW domains. The WW domain is a protein motif consisting of 35 to 40 amino acids and is characterized by 4 conserved aromatic residues. The WW domain may mediate specific protein-protein interactions. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: WWP2 WW domain containing E3 ubiquitin protein ligase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11060| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
WWP2 has been shown to [[Protein–protein interaction|interact]] with [[SCNN1B]]<ref name="pmid12167593" /><ref name="pmid11244092">{{cite journal | vauthors = Harvey KF, Dinudom A, Cook DI, Kumar S | title = The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel | journal = J. Biol. Chem. | volume = 276 | issue = 11 | pages = 8597–601 | date = March 2001 | pmid = 11244092 | doi = 10.1074/jbc.C000906200 }}</ref> and [[ATN1]].<ref name="pmid9647693">{{cite journal | vauthors = Wood JD, Yuan J, Margolis RL, Colomer V, Duan K, Kushi J, Kaminsky Z, Kleiderlein JJ, Sharp AH, Ross CA | title = Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins | journal = Mol. Cell. Neurosci. | volume = 11 | issue = 3 | pages = 149–60 | date = June 1998 | pmid = 9647693 | doi = 10.1006/mcne.1998.0677 }}</ref>
 
== Clinical significance ==
 
Full-length WWP2 (WWP2-FL), together with [[N-terminus|N-terminal]], (WWP2-N); [[C-terminus|C-terminal]] (WWP2-C) isoforms bind to [[SMAD (protein)|SMAD]] proteins.  WWP2-FL interacts with [[Mothers against decapentaplegic homolog 2|SMAD2]], [[Mothers against decapentaplegic homolog 3|SMAD3]] and [[Mothers against decapentaplegic homolog 7|SMAD7]] in the [[TGF beta signaling pathway|TGF-β pathway]]. The WWP2-N isoform interacts with SMAD2 and SMAD3, whereas WWP2-C interacts only with SMAD7. Disruption of interactions between WWP2 and SMAD7 can stabilize SMAD7 protein levels and prevent TGF-β induced [[Epithelial-mesenchymal transition]]. Hence inhibiting WWP2 may in turn lead to the disabling of an inhibitor that normally controls cell growth and [[tumorogenesis]]. In tissue cultures lacking the inhibitor [[SMAD7]], cancer cells spread rapidly, so that silencing WWP2 prevented the spread.<ref name=Soond_2011>{{cite journal | vauthors = Soond SM, Chantry A | title = Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGFβ signalling and EMT | journal = Oncogene | volume = 30 | issue = 21 | pages = 2451–62 | year = 2011 | pmid = 21258410 | doi = 10.1038/onc.2010.617 | laysummary = http://www.bbc.co.uk/news/health-12254242 | laysource = BBC News }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Jonsson AB | title = Identification of a human cDNA clone that mediates adherence of pathogenic Neisseria to non-binding cells. | journal = FEMS Microbiol. Lett. | volume = 162 | issue = 1 | pages = 25–30 | year = 1998 | pmid = 9595660 | doi = 10.1111/j.1574-6968.1998.tb12974.x }}
| citations =
* {{cite journal | vauthors = Wood JD, Yuan J, Margolis RL, Colomer V, Duan K, Kushi J, Kaminsky Z, Kleiderlein JJ, Sharp AH, Ross CA | title = Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins. | journal = Mol. Cell. Neurosci. | volume = 11 | issue = 3 | pages = 149–60 | year = 1998 | pmid = 9647693 | doi = 10.1006/mcne.1998.0677 }}
*{{cite journal | author=Pirozzi G, McConnell SJ, Uveges AJ, ''et al.'' |title=Identification of novel human WW domain-containing proteins by cloning of ligand targets. |journal=J. Biol. Chem. |volume=272 |issue= 23 |pages= 14611-6 |year= 1997 |pmid= 9169421 |doi=  }}
* {{cite journal | vauthors = Winberg G, Matskova L, Chen F, Plant P, Rotin D, Gish G, Ingham R, Ernberg I, Pawson T | title = Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases. | journal = Mol. Cell. Biol. | volume = 20 | issue = 22 | pages = 8526–35 | year = 2000 | pmid = 11046148 | pmc = 102158 | doi = 10.1128/MCB.20.22.8526-8535.2000 }}
*{{cite journal  | author=Jonsson AB |title=Identification of a human cDNA clone that mediates adherence of pathogenic Neisseria to non-binding cells. |journal=FEMS Microbiol. Lett. |volume=162 |issue= 1 |pages= 25-30 |year= 1998 |pmid= 9595660 |doi= }}
* {{cite journal | vauthors = Harvey KF, Shearwin-Whyatt LM, Fotia A, Parton RG, Kumar S | title = N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein. | journal = J. Biol. Chem. | volume = 277 | issue = 11 | pages = 9307–17 | year = 2002 | pmid = 11748237 | doi = 10.1074/jbc.M110443200 }}
*{{cite journal | author=Wood JD, Yuan J, Margolis RL, ''et al.'' |title=Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins. |journal=Mol. Cell. Neurosci. |volume=11 |issue= 3 |pages= 149-60 |year= 1998 |pmid= 9647693 |doi= 10.1006/mcne.1998.0677 }}
* {{cite journal | vauthors = Galinier R, Gout E, Lortat-Jacob H, Wood J, Chroboczek J | title = Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases. | journal = Biochemistry | volume = 41 | issue = 48 | pages = 14299–305 | year = 2003 | pmid = 12450395 | doi = 10.1021/bi020125b }}
*{{cite journal | author=Winberg G, Matskova L, Chen F, ''et al.'' |title=Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases. |journal=Mol. Cell. Biol. |volume=20 |issue= 22 |pages= 8526-35 |year= 2000 |pmid= 11046148 |doi= }}
* {{cite journal | vauthors = Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM | title = Functional proteomics mapping of a human signaling pathway. | journal = Genome Res. | volume = 14 | issue = 7 | pages = 1324–32 | year = 2004 | pmid = 15231748 | pmc = 442148 | doi = 10.1101/gr.2334104 }}
*{{cite journal | author=Harvey KF, Shearwin-Whyatt LM, Fotia A, ''et al.'' |title=N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein. |journal=J. Biol. Chem. |volume=277 |issue= 11 |pages= 9307-17 |year= 2002 |pmid= 11748237 |doi= 10.1074/jbc.M110443200 }}
* {{cite journal | vauthors = Shearwin-Whyatt LM, Brown DL, Wylie FG, Stow JL, Kumar S | title = N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking. | journal = J. Cell Sci. | volume = 117 | issue = Pt 16 | pages = 3679–89 | year = 2005 | pmid = 15252135 | doi = 10.1242/jcs.01212 }}
*{{cite journal | author=McDonald FJ, Western AH, McNeil JD, ''et al.'' |title=Ubiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na(+) channel. |journal=Am. J. Physiol. Renal Physiol. |volume=283 |issue= 3 |pages= F431-6 |year= 2002 |pmid= 12167593 |doi= 10.1152/ajprenal.00080.2002 }}
* {{cite journal | vauthors = Rougier JS, van Bemmelen MX, Bruce MC, Jespersen T, Gavillet B, Apothéloz F, Cordonier S, Staub O, Rotin D, Abriel H | title = Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteins. | journal = Am. J. Physiol., Cell Physiol. | volume = 288 | issue = 3 | pages = C692–701 | year = 2005 | pmid = 15548568 | doi = 10.1152/ajpcell.00460.2004 }}
*{{cite journal  | author=Galinier R, Gout E, Lortat-Jacob H, ''et al.'' |title=Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases. |journal=Biochemistry |volume=41 |issue= 48 |pages= 14299-305 |year= 2003 |pmid= 12450395 |doi=  }}
* {{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network. | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY | title = A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. | journal = Cell | volume = 125 | issue = 4 | pages = 801–14 | year = 2006 | pmid = 16713569 | doi = 10.1016/j.cell.2006.03.032 }}
*{{cite journal | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
* {{cite journal | vauthors = Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP | title = A probability-based approach for high-throughput protein phosphorylation analysis and site localization. | journal = Nat. Biotechnol. | volume = 24 | issue = 10 | pages = 1285–92 | year = 2006 | pmid = 16964243 | doi = 10.1038/nbt1240 }}
*{{cite journal | author=Shearwin-Whyatt LM, Brown DL, Wylie FG, ''et al.'' |title=N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking. |journal=J. Cell. Sci. |volume=117 |issue= Pt 16 |pages= 3679-89 |year= 2005 |pmid= 15252135 |doi= 10.1242/jcs.01212 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rougier JS, van Bemmelen MX, Bruce MC, ''et al.'' |title=Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteins. |journal=Am. J. Physiol., Cell Physiol. |volume=288 |issue= 3 |pages= C692-701 |year= 2005 |pmid= 15548568 |doi= 10.1152/ajpcell.00460.2004 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{Ligases CO CS and CN}}
{{Enzymes}}
{{Portal bar|Molecular and Cellular Biology|border=no}}
 
[[Category:EC 6.3.2]]
 
 
{{gene-16-stub}}

Revision as of 22:38, 8 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
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View/Edit Human

NEDD4-liثثبقثke E3 ubiquitin-protein ligase WWP2 also known as atrophin-1-interacting protein 2 (AIP2) or WW domain-containing protein 2 (WWP2) is an enzyme that in humans is encoded by the WWP2 gene.[1][2][3]

Function

This gene encodes a member of the NEDD4-like protein family. The family of proteins is known to possess ubiquitin-protein ligase activity. The encoded protein contains 4 tandem WW domains. The WW domain is a protein motif consisting of 35 to 40 amino acids and is characterized by 4 conserved aromatic residues. The WW domain may mediate specific protein–protein interactions. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[3]

Interactions

WWP2 has been shown to interact with SCNN1B[2][4] and ATN1.[5]

Clinical significance

Full-length WWP2 (WWP2-FL), together with N-terminal, (WWP2-N); C-terminal (WWP2-C) isoforms bind to SMAD proteins. WWP2-FL interacts with SMAD2, SMAD3 and SMAD7 in the TGF-β pathway. The WWP2-N isoform interacts with SMAD2 and SMAD3, whereas WWP2-C interacts only with SMAD7. Disruption of interactions between WWP2 and SMAD7 can stabilize SMAD7 protein levels and prevent TGF-β induced Epithelial-mesenchymal transition. Hence inhibiting WWP2 may in turn lead to the disabling of an inhibitor that normally controls cell growth and tumorogenesis. In tissue cultures lacking the inhibitor SMAD7, cancer cells spread rapidly, so that silencing WWP2 prevented the spread.[6]

References

  1. ↑ Pirozzi G, McConnell SJ, Uveges AJ, Carter JM, Sparks AB, Kay BK, Fowlkes DM (Jun 1997). "Identification of novel human WW domain-containing proteins by cloning of ligand targets". J Biol Chem. 272 (23): 14611–6. doi:10.1074/jbc.272.23.14611. PMID 9169421.
  2. ↑ 2.0 2.1 McDonald FJ, Western AH, McNeil JD, Thomas BC, Olson DR, Snyder PM (Aug 2002). "Ubiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na(+) channel". Am J Physiol Renal Physiol. 283 (3): F431–6. doi:10.1152/ajprenal.00080.2002. PMID 12167593.
  3. ↑ 3.0 3.1 "Entrez Gene: WWP2 WW domain containing E3 ubiquitin protein ligase 2".
  4. ↑ Harvey KF, Dinudom A, Cook DI, Kumar S (March 2001). "The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel". J. Biol. Chem. 276 (11): 8597–601. doi:10.1074/jbc.C000906200. PMID 11244092.
  5. ↑ Wood JD, Yuan J, Margolis RL, Colomer V, Duan K, Kushi J, Kaminsky Z, Kleiderlein JJ, Sharp AH, Ross CA (June 1998). "Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins". Mol. Cell. Neurosci. 11 (3): 149–60. doi:10.1006/mcne.1998.0677. PMID 9647693.
  6. ↑ Soond SM, Chantry A (2011). "Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGFβ signalling and EMT". Oncogene. 30 (21): 2451–62. doi:10.1038/onc.2010.617. PMID 21258410. Lay summary – BBC News.

Further reading

  • Jonsson AB (1998). "Identification of a human cDNA clone that mediates adherence of pathogenic Neisseria to non-binding cells". FEMS Microbiol. Lett. 162 (1): 25–30. doi:10.1111/j.1574-6968.1998.tb12974.x. PMID 9595660.
  • Wood JD, Yuan J, Margolis RL, Colomer V, Duan K, Kushi J, Kaminsky Z, Kleiderlein JJ, Sharp AH, Ross CA (1998). "Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins". Mol. Cell. Neurosci. 11 (3): 149–60. doi:10.1006/mcne.1998.0677. PMID 9647693.
  • Winberg G, Matskova L, Chen F, Plant P, Rotin D, Gish G, Ingham R, Ernberg I, Pawson T (2000). "Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases". Mol. Cell. Biol. 20 (22): 8526–35. doi:10.1128/MCB.20.22.8526-8535.2000. PMC 102158. PMID 11046148.
  • Harvey KF, Shearwin-Whyatt LM, Fotia A, Parton RG, Kumar S (2002). "N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein". J. Biol. Chem. 277 (11): 9307–17. doi:10.1074/jbc.M110443200. PMID 11748237.
  • Galinier R, Gout E, Lortat-Jacob H, Wood J, Chroboczek J (2003). "Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases". Biochemistry. 41 (48): 14299–305. doi:10.1021/bi020125b. PMID 12450395.
  • Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
  • Shearwin-Whyatt LM, Brown DL, Wylie FG, Stow JL, Kumar S (2005). "N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking". J. Cell Sci. 117 (Pt 16): 3679–89. doi:10.1242/jcs.01212. PMID 15252135.
  • Rougier JS, van Bemmelen MX, Bruce MC, Jespersen T, Gavillet B, Apothéloz F, Cordonier S, Staub O, Rotin D, Abriel H (2005). "Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteins". Am. J. Physiol., Cell Physiol. 288 (3): C692–701. doi:10.1152/ajpcell.00460.2004. PMID 15548568.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
  • Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.


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