Uroguanylin: Difference between revisions

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'''Uroguanylin''' is a 16 [[amino acid]] [[peptide]] that is secreted by [[enterochromaffin cells]] in the [[duodenum]] and proximal [[small intestine]]. Guanylin acts as an [[agonist]] of the [[guanylyl cyclase]] receptor [[guanylate cyclase 2C]] (GC-C), and regulates [[electrolyte]] and [[water]] transport in [[intestinal]] and [[renal]] [[epithelia]]. Its sequence is H-Asn-Asp-Asp-Cys(1)-Glu-Leu-Cys(2)-Val-Asn-Val-Ala-Cys(1)-Thr-Gly-Cys(2)-Leu-OH.
'''Uroguanylin''' is a 16 [[amino acid]] [[peptide]] that is secreted by [[enterochromaffin cells]] in the [[duodenum]] and proximal [[small intestine]]. Guanylin acts as an [[agonist]] of the [[guanylyl cyclase]] receptor [[guanylate cyclase 2C]] (GC-C), and regulates [[electrolyte]] and [[water]] transport in [[intestinal]] and [[renal]] [[epithelia]]. Its sequence is H-Asn-Asp-Asp-Cys(1)-Glu-Leu-Cys(2)-Val-Asn-Val-Ala-Cys(1)-Thr-Gly-Cys(2)-Leu-OH.


In humans, the uroguanylin peptide is encoded by the ''GUCA2B'' [[gene]].<ref name="Miyazato-1996">{{Cite journal | last1 = Miyazato | first1 = M. | last2 = Nakazato | first2 = M. | last3 = Yamaguchi | first3 = H. | last4 = Date | first4 = Y. | last5 = Kojima | first5 = M. | last6 = Kangawa | first6 = K. | last7 = Matsuo | first7 = H. | last8 = Matsukura | first8 = S. | title = Cloning and characterization of a cDNA encoding a precursor for human uroguanylin. | journal = Biochem Biophys Res Commun | volume = 219 | issue = 2 | pages = 644–8 | date = Feb 1996 | doi = 10.1006/bbrc.1996.0287 | PMID = 8605041 }}</ref><ref name="Miyazato-1997">{{Cite journal | last1 = Miyazato | first1 = M. | last2 = Nakazato | first2 = M. | last3 = Matsukura | first3 = S. | last4 = Kangawa | first4 = K. | last5 = Matsuo | first5 = H. | title = Genomic structure and chromosomal localization of human uroguanylin. | journal = Genomics | volume = 43 | issue = 3 | pages = 359–65 | date = Aug 1997 | doi = 10.1006/geno.1997.4808 | PMID = 9268639 }}</ref> Uroguanylin may be involved in appetite and perceptions of 'fullness' after eating meals, as suggested by a study into mice.<ref name="Rahbi-H-2012">{{Cite journal | last1 = Rahbi | first1 = H. | last2 = Narayan | first2 = H. | last3 = Jones| first3 = D.J. | last4 = Ng | first4 = L.L. | title = The uroguanylin system and human disease. | journal = Clin. Sci. (Lond) | volume = 123 | issue = 12 | pages = 659–668 | date = Dec 2012 | doi = 10.1042/CS20120021 | PMID = 22877138}}</ref>
In humans, the uroguanylin peptide is encoded by the ''GUCA2B'' [[gene]].<ref name="Miyazato-1996">{{cite journal | vauthors = Miyazato M, Nakazato M, Yamaguchi H, Date Y, Kojima M, Kangawa K, Matsuo H, Matsukura S | title = Cloning and characterization of a cDNA encoding a precursor for human uroguanylin | journal = Biochemical and Biophysical Research Communications | volume = 219 | issue = 2 | pages = 644–8 | date = February 1996 | pmid = 8605041 | doi = 10.1006/bbrc.1996.0287 }}</ref><ref name="Miyazato-1997">{{cite journal | vauthors = Miyazato M, Nakazato M, Matsukura S, Kangawa K, Matsuo H | title = Genomic structure and chromosomal localization of human uroguanylin | journal = Genomics | volume = 43 | issue = 3 | pages = 359–65 | date = August 1997 | pmid = 9268639 | doi = 10.1006/geno.1997.4808 }}</ref> Uroguanylin may be involved in appetite and perceptions of 'fullness' after eating meals, as suggested by a study into mice.<ref name="Rahbi-H-2012">{{cite journal | vauthors = Rahbi H, Narayan H, Jones DJ, Ng LL | title = The uroguanylin system and human disease | journal = Clinical Science | volume = 123 | issue = 12 | pages = 659–68 | date = December 2012 | pmid = 22877138 | doi = 10.1042/CS20120021 }}</ref>


==See also==
== See also ==
* [[Natriuretic peptide]]
* [[Natriuretic peptide]]
* [[Plecanatide]] – a medication structurally related to uroguanylin
* [[Plecanatide]] – a medication structurally related to uroguanylin


==References==
== References ==
{{Reflist}}
{{Reflist}}


==External links==
== External links ==
* {{MeshName|uroguanylin}}
* {{MeshName|uroguanylin}}


[[Category:Peptides]]
[[Category:Peptides]]
[[Category:Digestive system]]
[[Category:Digestive system]]


{{biochem-stub}}
{{biochem-stub}}

Latest revision as of 17:34, 7 February 2018

guanylate cyclase activator 2B (uroguanylin)
Identifiers
SymbolGUCA2B
Entrez2981
HUGO4683
OMIM601271
RefSeqNM_007102
UniProtQ16661
Other data
LocusChr. 1 p34-p33
Template:Chembox E number
Uroguanylin
Stereo, skeletal formula of uroguanylin
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value). Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value).
MeSH uroguanylin
Properties
C61H101N17O25S4
Molar mass 1,600.81 g·mol−1
Related compounds
Related compounds
 PMDTA
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Uroguanylin is a 16 amino acid peptide that is secreted by enterochromaffin cells in the duodenum and proximal small intestine. Guanylin acts as an agonist of the guanylyl cyclase receptor guanylate cyclase 2C (GC-C), and regulates electrolyte and water transport in intestinal and renal epithelia. Its sequence is H-Asn-Asp-Asp-Cys(1)-Glu-Leu-Cys(2)-Val-Asn-Val-Ala-Cys(1)-Thr-Gly-Cys(2)-Leu-OH.

In humans, the uroguanylin peptide is encoded by the GUCA2B gene.[1][2] Uroguanylin may be involved in appetite and perceptions of 'fullness' after eating meals, as suggested by a study into mice.[3]

See also

References

  1. ↑ Miyazato M, Nakazato M, Yamaguchi H, Date Y, Kojima M, Kangawa K, Matsuo H, Matsukura S (February 1996). "Cloning and characterization of a cDNA encoding a precursor for human uroguanylin". Biochemical and Biophysical Research Communications. 219 (2): 644–8. doi:10.1006/bbrc.1996.0287. PMID 8605041.
  2. ↑ Miyazato M, Nakazato M, Matsukura S, Kangawa K, Matsuo H (August 1997). "Genomic structure and chromosomal localization of human uroguanylin". Genomics. 43 (3): 359–65. doi:10.1006/geno.1997.4808. PMID 9268639.
  3. ↑ Rahbi H, Narayan H, Jones DJ, Ng LL (December 2012). "The uroguanylin system and human disease". Clinical Science. 123 (12): 659–68. doi:10.1042/CS20120021. PMID 22877138.

External links

Retrieved from "https://www.wikidoc.org/index.php?title=Uroguanylin&oldid=1530343"