Uroguanylin: Difference between revisions

Uroguanylin
	Stereo, skeletal formula of uroguanylin
Identifiers
CAS Number	152175-68-3 ;
3D model (JSmol)	Interactive image;
ChemSpider	4589972 ;
ECHA InfoCard	Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value). Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value).
MeSH	uroguanylin
PubChem CID	5488765;
	InChI InChI=1S/C64H102N18O26S4/c1-24(2)13-32-53(96)79-40-23-112-109-20-37(57(100)76-36(64(107)108)14-25(3)4)70-43(86)19-68-61(104)49(29(10)83)82-60(103)39(77-50(93)28(9)69-62(105)47(26(5)6)80-56(99)33(16-42(67)85)75-63(106)48(27(7)8)81-59(40)102)22-111-110-21-38(58(101)71-31(52(95)73-32)11-12-44(87)88)78-55(98)35(18-46(91)92)74-54(97)34(17-45(89)90)72-51(94)30(65)15-41(66)84/h24-40,47-49,83H,11-23,65H2,1-10H3,(H2,66,84)(H2,67,85)(H,68,104)(H,69,105)(H,70,86)(H,71,101)(H,72,94)(H,73,95)(H,74,97)(H,75,106)(H,76,100)(H,77,93)(H,78,98)(H,79,96)(H,80,99)(H,81,102)(H,82,103)(H,87,88)(H,89,90)(H,91,92)(H,107,108)/t28-,29+,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,47-,48-,49-/m0/s1 Key: VQZRYOAXGUCZMI-HWMZBCIHSA-N ;
	SMILES C[C@H]1C(=O)N[C@H]2CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H](NC(=O)CNC(=O)[C@@H](NC2=O)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)C(C)C)CC(=O)N)C(C)C)CC(C)C)CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)N)N;
Properties
Chemical formula	C61H101N17O25S4
Molar mass	1,600.81 g·mol−1
Related compounds
Related compounds	PMDTA
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	Infobox references

guanylate cyclase activator 2B (uroguanylin)
Identifiers
Symbol	GUCA2B
Entrez	2981
HUGO	4683
OMIM	601271
RefSeq	NM_007102
UniProt	Q16661
Other data
Locus	Chr. 1 p34-p33

VisualWikitext

Latest revision as of 17:34, 7 February 2018

Template:Chembox E number

Uroguanylin is a 16 amino acid peptide that is secreted by enterochromaffin cells in the duodenum and proximal small intestine. Guanylin acts as an agonist of the guanylyl cyclase receptor guanylate cyclase 2C (GC-C), and regulates electrolyte and water transport in intestinal and renal epithelia. Its sequence is H-Asn-Asp-Asp-Cys(1)-Glu-Leu-Cys(2)-Val-Asn-Val-Ala-Cys(1)-Thr-Gly-Cys(2)-Leu-OH.

In humans, the uroguanylin peptide is encoded by the GUCA2B gene.^[1]^[2] Uroguanylin may be involved in appetite and perceptions of 'fullness' after eating meals, as suggested by a study into mice.^[3]

References

↑ Miyazato M, Nakazato M, Yamaguchi H, Date Y, Kojima M, Kangawa K, Matsuo H, Matsukura S (February 1996). "Cloning and characterization of a cDNA encoding a precursor for human uroguanylin". Biochemical and Biophysical Research Communications. 219 (2): 644–8. doi:10.1006/bbrc.1996.0287. PMID 8605041.
↑ Miyazato M, Nakazato M, Matsukura S, Kangawa K, Matsuo H (August 1997). "Genomic structure and chromosomal localization of human uroguanylin". Genomics. 43 (3): 359–65. doi:10.1006/geno.1997.4808. PMID 9268639.
↑ Rahbi H, Narayan H, Jones DJ, Ng LL (December 2012). "The uroguanylin system and human disease". Clinical Science. 123 (12): 659–68. doi:10.1042/CS20120021. PMID 22877138.

External links

uroguanylin at the US National Library of Medicine Medical Subject Headings (MeSH)

Stub icon

This biochemistry article is a stub. You can help Wikipedia by expanding it.

[Miyazato-1996-1] Miyazato M, Nakazato M, Yamaguchi H, Date Y, Kojima M, Kangawa K, Matsuo H, Matsukura S (February 1996). "Cloning and characterization of a cDNA encoding a precursor for human uroguanylin". Biochemical and Biophysical Research Communications. 219 (2): 644–8. doi:10.1006/bbrc.1996.0287. PMID 8605041.

[Miyazato-1997-2] Miyazato M, Nakazato M, Matsukura S, Kangawa K, Matsuo H (August 1997). "Genomic structure and chromosomal localization of human uroguanylin". Genomics. 43 (3): 359–65. doi:10.1006/geno.1997.4808. PMID 9268639.

[Rahbi-H-2012-3] Rahbi H, Narayan H, Jones DJ, Ng LL (December 2012). "The uroguanylin system and human disease". Clinical Science. 123 (12): 659–68. doi:10.1042/CS20120021. PMID 22877138.

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
+{{infobox protein
+| Name=guanylate cyclase activator 2B (uroguanylin)
+| HGNCid=4683
+| Symbol=GUCA2B
+| AltSymbols=
+| EntrezGene=2981
+| OMIM=601271
+| RefSeq=NM_007102
+| UniProt=Q16661
+| PDB=
+| ECnumber=
+| Chromosome=1
+| Arm=p
+| Band=34
+| LocusSupplementaryData=-p33
+}}
+{{Chembox
+| ImageFile = Uroguanylin.svg
+| ImageFile_Ref = {{chemboximage|correct|??}}
+| ImageName = Stereo, skeletal formula of uroguanylin
+|Section1={{Chembox Identifiers
+| CASNo = 152175-68-3
+| CASNo_Ref = {{cascite|correct|??}}
+| PubChem = 5488765
+| ChemSpiderID = 4589972
+| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
+| MeSHName = uroguanylin
+| SMILES = C[C@H]1C(=O)N[C@H]2CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H](NC(=O)CNC(=O)[C@@H](NC2=O)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)C(C)C)CC(=O)N)C(C)C)CC(C)C)CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)N)N
+| StdInChI = 1S/C64H102N18O26S4/c1-24(2)13-32-53(96)79-40-23-112-109-20-37(57(100)76-36(64(107)108)14-25(3)4)70-43(86)19-68-61(104)49(29(10)83)82-60(103)39(77-50(93)28(9)69-62(105)47(26(5)6)80-56(99)33(16-42(67)85)75-63(106)48(27(7)8)81-59(40)102)22-111-110-21-38(58(101)71-31(52(95)73-32)11-12-44(87)88)78-55(98)35(18-46(91)92)74-54(97)34(17-45(89)90)72-51(94)30(65)15-41(66)84/h24-40,47-49,83H,11-23,65H2,1-10H3,(H2,66,84)(H2,67,85)(H,68,104)(H,69,105)(H,70,86)(H,71,101)(H,72,94)(H,73,95)(H,74,97)(H,75,106)(H,76,100)(H,77,93)(H,78,98)(H,79,96)(H,80,99)(H,81,102)(H,82,103)(H,87,88)(H,89,90)(H,91,92)(H,107,108)/t28-,29+,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,47-,48-,49-/m0/s1
+| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
+| StdInChIKey = VQZRYOAXGUCZMI-HWMZBCIHSA-N
+| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
+}}
+|Section2={{Chembox Properties
+| C=61 | H=101 | N=17 | O=25 | S=4
+}}
+|Section3={{Chembox Related
+| OtherCompounds = [[PMDTA]]
+}}
+}}
+'''Uroguanylin''' is a 16 [[amino acid]] [[peptide]] that is secreted by [[enterochromaffin cells]] in the [[duodenum]] and proximal [[small intestine]]. Guanylin acts as an [[agonist]] of the [[guanylyl cyclase]] receptor [[guanylate cyclase 2C]] (GC-C), and regulates [[electrolyte]] and [[water]] transport in [[intestinal]] and [[renal]] [[epithelia]]. Its sequence is H-Asn-Asp-Asp-Cys(1)-Glu-Leu-Cys(2)-Val-Asn-Val-Ala-Cys(1)-Thr-Gly-Cys(2)-Leu-OH.
-==Overview==
+In humans, the uroguanylin peptide is encoded by the ''GUCA2B'' [[gene]].<ref name="Miyazato-1996">{{cite journal | vauthors = Miyazato M, Nakazato M, Yamaguchi H, Date Y, Kojima M, Kangawa K, Matsuo H, Matsukura S | title = Cloning and characterization of a cDNA encoding a precursor for human uroguanylin | journal = Biochemical and Biophysical Research Communications | volume = 219 | issue = 2 | pages = 644–8 | date = February 1996 | pmid = 8605041 | doi = 10.1006/bbrc.1996.0287 }}</ref><ref name="Miyazato-1997">{{cite journal | vauthors = Miyazato M, Nakazato M, Matsukura S, Kangawa K, Matsuo H | title = Genomic structure and chromosomal localization of human uroguanylin | journal = Genomics | volume = 43 | issue = 3 | pages = 359–65 | date = August 1997 | pmid = 9268639 | doi = 10.1006/geno.1997.4808 }}</ref> Uroguanylin may be involved in appetite and perceptions of 'fullness' after eating meals, as suggested by a study into mice.<ref name="Rahbi-H-2012">{{cite journal | vauthors = Rahbi H, Narayan H, Jones DJ, Ng LL | title = The uroguanylin system and human disease | journal = Clinical Science | volume = 123 | issue = 12 | pages = 659–68 | date = December 2012 | pmid = 22877138 | doi = 10.1042/CS20120021 }}</ref>
-{{protein
-|Name=guanylate cyclase activator 2B (uroguanylin)
-|caption=
-|image=
-|width=
-|HGNCid=4683
-|Symbol=GUCA2B
-|AltSymbols=
-|EntrezGene=2981
-|OMIM=601271
-|RefSeq=NM_007102
-|UniProt=Q16661
-|PDB=
-|ECnumber=
-|Chromosome=1
-|Arm=p
-|Band=34
-|LocusSupplementaryData=-p33
-}}
-{{SI}}
-'''Uroguanylin''' is a 16 [[amino acid]] [[peptide]] that is secreted by [[enterochromaffin cells]] in the [[duodenum]] and proximal [[small intestine]]. Guanylin acts as an [[agonist]] of the [[guanylyl cyclase]] receptor [[GC-C]] and regulates [[electrolyte]] and [[water]] transport in [[intestinal]] and [[renal]] [[epithelia]].
-==See also==
+== See also ==
 * [[Natriuretic peptide]]
+* [[Plecanatide]] – a medication structurally related to uroguanylin
+== References ==
+{{Reflist}}
-==External links==
+== External links ==
 * {{MeshName|uroguanylin}}
@@ Line 33: / Line 57: @@
 [[Category:Digestive system]]
+{{biochem-stub}}
-{{WikiDoc Help Menu}}
-{{WikiDoc Sources}}

Identifiers
Stereo, skeletal formula of uroguanylin
CAS Number	152175-68-3^Y
3D model (JSmol)	Interactive image
ChemSpider	4589972^Y
ECHA InfoCard	Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value). Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value).
MeSH	uroguanylin
PubChem CID	5488765
InChI InChI=1S/C64H102N18O26S4/c1-24(2)13-32-53(96)79-40-23-112-109-20-37(57(100)76-36(64(107)108)14-25(3)4)70-43(86)19-68-61(104)49(29(10)83)82-60(103)39(77-50(93)28(9)69-62(105)47(26(5)6)80-56(99)33(16-42(67)85)75-63(106)48(27(7)8)81-59(40)102)22-111-110-21-38(58(101)71-31(52(95)73-32)11-12-44(87)88)78-55(98)35(18-46(91)92)74-54(97)34(17-45(89)90)72-51(94)30(65)15-41(66)84/h24-40,47-49,83H,11-23,65H2,1-10H3,(H2,66,84)(H2,67,85)(H,68,104)(H,69,105)(H,70,86)(H,71,101)(H,72,94)(H,73,95)(H,74,97)(H,75,106)(H,76,100)(H,77,93)(H,78,98)(H,79,96)(H,80,99)(H,81,102)(H,82,103)(H,87,88)(H,89,90)(H,91,92)(H,107,108)/t28-,29+,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,47-,48-,49-/m0/s1^Y Key: VQZRYOAXGUCZMI-HWMZBCIHSA-N^Y
SMILES C[C@H]1C(=O)N[C@H]2CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H](NC(=O)CNC(=O)[C@@H](NC2=O)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)C(C)C)CC(=O)N)C(C)C)CC(C)C)CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)N)N
Properties
Chemical formula	C₆₁H₁₀₁N₁₇O₂₅S₄
Molar mass	1,600.81 g·mol⁻¹
Related compounds
Related compounds	PMDTA
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Uroguanylin: Difference between revisions

Latest revision as of 17:34, 7 February 2018

See also

References

External links

Navigation menu