USO1

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

General vesicular transport factor p115 is a protein that in humans is encoded by the USO1 gene.[1][2][3][4][5][6]

Function

The protein encoded by this gene is a peripheral membrane protein which recycles between the cytosol and the Golgi apparatus during interphase. It is regulated by phosphorylation: dephosphorylated protein associates with the Golgi membrane and dissociates from the membrane upon phosphorylation. Ras-associated protein 1 recruits this protein to coat protein complex II (COPII) vesicles during budding from the endoplasmic reticulum (ER), where it interacts with a set of COPII vesicle-associated SNAREs to form a cis-SNARE complex that promotes targeting to the Golgi apparatus. Transport from the ER to the cis/medial Golgi compartments requires the action of this gene product, GOLGA2, and giantin in a sequential manner.[6]

Interactions

USO1 has been shown to interact with:

References

  1. Sohda M, Misumi Y, Yano A, Takami N, Ikehara Y (March 1998). "Phosphorylation of the vesicle docking protein p115 regulates its association with the Golgi membrane". J Biol Chem. 273 (9): 5385–8. doi:10.1074/jbc.273.9.5385. PMID 9478999.
  2. Nakamura N, Lowe M, Levine TP, Rabouille C, Warren G (June 1997). "The vesicle docking protein p115 binds GM130, a cis-Golgi matrix protein, in a mitotically regulated manner". Cell. 89 (3): 445–55. doi:10.1016/S0092-8674(00)80225-1. PMID 9150144.
  3. Whyte JR, Munro S (June 2002). "Vesicle tethering complexes in membrane traffic". J Cell Sci. 115 (Pt 13): 2627–37. PMID 12077354.
  4. Short B, Haas A, Barr FA (June 2005). "Golgins and GTPases, giving identity and structure to the Golgi apparatus". Biochim Biophys Acta. 1744 (3): 383–95. doi:10.1016/j.bbamcr.2005.02.001. PMID 15979508.
  5. Puthenveedu MA, Linstedt AD (February 2004). "Gene replacement reveals that p115/SNARE interactions are essential for Golgi biogenesis". Proc Natl Acad Sci U S A. 101 (5): 1253–6. doi:10.1073/pnas.0306373101. PMC 337039. PMID 14736916.
  6. 6.0 6.1 "Entrez Gene: VDP vesicle docking protein p115".
  7. 7.0 7.1 7.2 7.3 Shorter J, Beard MB, Seemann J, Dirac-Svejstrup AB, Warren G (April 2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115". J. Cell Biol. 157 (1): 45–62. doi:10.1083/jcb.200112127. PMC 2173270. PMID 11927603.
  8. 8.0 8.1 8.2 Allan BB, Moyer BD, Balch WE (July 2000). "Rab1 recruitment of p115 into a cis-SNARE complex: programming budding COPII vesicles for fusion". Science. 289 (5478): 444–8. doi:10.1126/science.289.5478.444. PMID 10903204.

Further reading