The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. The golgins are a family of proteins, of which the protein encoded by this gene is a member, that are localized to the Golgi. This encoded protein has been postulated to play roles in the stacking of Golgi cisternae and in vesicular transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of these variants has not been determined.[2]
↑Marra P, Maffucci T, Daniele T, Tullio GD, Ikehara Y, Chan EK, Luini A, Beznoussenko G, Mironov A, De Matteis MA (Dec 2001). "The GM130 and GRASP65 Golgi proteins cycle through and define a subdomain of the intermediate compartment". Nature Cell Biology. 3 (12): 1101–13. doi:10.1038/ncb1201-1101. PMID11781572.
↑Weide T, Teuber J, Bayer M, Barnekow A (Jun 2003). "MICAL-1 isoforms, novel rab1 interacting proteins". Biochemical and Biophysical Research Communications. 306 (1): 79–86. doi:10.1016/s0006-291x(03)00918-5. PMID12788069.
↑Valsdottir R, Hashimoto H, Ashman K, Koda T, Storrie B, Nilsson T (Nov 2001). "Identification of rabaptin-5, rabex-5, and GM130 as putative effectors of rab33b, a regulator of retrograde traffic between the Golgi apparatus and ER". FEBS Letters. 508 (2): 201–9. doi:10.1016/s0014-5793(01)02993-3. PMID11718716.
↑Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID16189514.
Nakamura N, Lowe M, Levine TP, Rabouille C, Warren G (May 1997). "The vesicle docking protein p115 binds GM130, a cis-Golgi matrix protein, in a mitotically regulated manner". Cell. 89 (3): 445–55. doi:10.1016/S0092-8674(00)80225-1. PMID9150144.
Barr FA, Puype M, Vandekerckhove J, Warren G (Oct 1997). "GRASP65, a protein involved in the stacking of Golgi cisternae". Cell. 91 (2): 253–62. doi:10.1016/S0092-8674(00)80407-9. PMID9346242.
Sohda M, Misumi Y, Yano A, Takami N, Ikehara Y (Feb 1998). "Phosphorylation of the vesicle docking protein p115 regulates its association with the Golgi membrane". The Journal of Biological Chemistry. 273 (9): 5385–8. doi:10.1074/jbc.273.9.5385. PMID9478999.
Lowe M, Rabouille C, Nakamura N, Watson R, Jackman M, Jämsä E, Rahman D, Pappin DJ, Warren G (Sep 1998). "Cdc2 kinase directly phosphorylates the cis-Golgi matrix protein GM130 and is required for Golgi fragmentation in mitosis". Cell. 94 (6): 783–93. doi:10.1016/S0092-8674(00)81737-7. PMID9753325.
Barr FA (Apr 1999). "A novel Rab6-interacting domain defines a family of Golgi-targeted coiled-coil proteins". Current Biology. 9 (7): 381–4. doi:10.1016/S0960-9822(99)80167-5. PMID10209123.
Bouchireb N, Clark MS (1999). "Human golgin-95 gene (GOLGA2). Map position 9q32-34.1". Chromosome Research : An International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology. 7 (6): 501. doi:10.1023/A:1009210232273. PMID10560974.
Linstedt AD, Jesch SA, Mehta A, Lee TH, Garcia-Mata R, Nelson DS, Sztul E (Apr 2000). "Binding relationships of membrane tethering components. The giantin N terminus and the GM130 N terminus compete for binding to the p115 C terminus". The Journal of Biological Chemistry. 275 (14): 10196–201. doi:10.1074/jbc.275.14.10196. PMID10744704.
Majoul I, Straub M, Hell SW, Duden R, Söling HD (Jul 2001). "KDEL-cargo regulates interactions between proteins involved in COPI vesicle traffic: measurements in living cells using FRET". Developmental Cell. 1 (1): 139–53. doi:10.1016/S1534-5807(01)00004-1. PMID11703931.
Valsdottir R, Hashimoto H, Ashman K, Koda T, Storrie B, Nilsson T (Nov 2001). "Identification of rabaptin-5, rabex-5, and GM130 as putative effectors of rab33b, a regulator of retrograde traffic between the Golgi apparatus and ER". FEBS Letters. 508 (2): 201–9. doi:10.1016/S0014-5793(01)02993-3. PMID11718716.
