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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Ubiquilin-1''' is a [[protein]] that in humans is encoded by the ''UBQLN1'' [[gene]].<ref name="pmid9303440">{{cite journal | vauthors = Ozaki T, Hishiki T, Toyama Y, Yuasa S, Nakagawara A, Sakiyama S | title = Identification of a new cellular protein that can interact specifically with DAN | journal = DNA Cell Biol | volume = 16 | issue = 8 | pages = 985–91 |date=Oct 1997 | pmid = 9303440 | pmc =  | doi =10.1089/dna.1997.16.985  }}</ref><ref name="pmid10807547">{{cite journal | vauthors = Hanaoka E, Ozaki T, Ohira M, Nakamura Y, Suzuki M, Takahashi E, Moriya H, Nakagawara A, Sakiyama S | title = Molecular cloning and expression analysis of the human DA41 gene and its mapping to chromosome 9q21.2-q21.3 | journal = J Hum Genet | volume = 45 | issue = 3 | pages = 188–91 |date=Jul 2000 | pmid = 10807547 | pmc = | doi = 10.1007/s100380050209 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: UBQLN1 ubiquilin 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29979| accessdate = }}</ref>
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| require_manual_inspection = no
Ubiquilins contain a [[N-terminus|N-terminal]] ubiquitin-like [[protein domain|domain]] and a C-terminal ubiquitin-associated domain. They physically associate with both [[proteasome]]s and ubiquitin [[ligase]]s, and thus are thought to functionally link the ubiquitination machinery to the proteasome to effect in vivo protein degradation.
| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
==Possible Role In Preventing Alzheimers Disease==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Ubiquilin 1
| HGNCid = 12508
| Symbol = UBQLN1
| AltSymbols =; DA41; DSK2; FLJ90054; PLIC-1; XDRP1
| OMIM = 605046
| ECnumber = 
| Homologene = 40881
| MGIid = 1860276
| Function = {{GNF_GO|id=GO:0019900 |text = kinase binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0043234 |text = protein complex}} {{GNF_GO|id=GO:0048471 |text = perinuclear region of cytoplasm}}
| Process = {{GNF_GO|id=GO:0006464 |text = protein modification process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 29979
    | Hs_Ensembl = ENSG00000135018
    | Hs_RefseqProtein = NP_038466
    | Hs_RefseqmRNA = NM_013438
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 85464698
    | Hs_GenLoc_end = 85512938
    | Hs_Uniprot = Q9UMX0
    | Mm_EntrezGene = 56085
    | Mm_Ensembl = ENSMUSG00000005312
    | Mm_RefseqmRNA = NM_026842
    | Mm_RefseqProtein = NP_081118
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 58185786
    | Mm_GenLoc_end = 58225259
    | Mm_Uniprot = Q66K07
  }}
}}
'''Ubiquilin 1''', also known as '''UBQLN1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: UBQLN1 ubiquilin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29979| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Ubiquilin has also been shown to modulate accumulation of presenilin proteins, and is found in lesions associated with [[Alzheimer's]] and [[Parkinson's]] disease. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez"/>
{{PBB_Summary
 
| section_title =
Higher levels of ubiquilin-1 in the brain decreased malformation of the APP molecule which plays a key role in triggering Alzheimers disease.<ref name="pmid21852239">{{cite journal | vauthors = Stieren ES, El Ayadi A, Xiao Y, Siller E, Landsverk ML, Oberhauser AF, Barral JM, Boehning D | title = Ubiquilin-1 Is a Molecular Chaperone for the Amyloid Precursor Protein | journal = J Biol Chem | volume = 286| issue = 41| pages = 35689–98|date=August 2011 | pmid = 21852239 | doi = 10.1074/jbc.M111.243147 | laysummary = https://www.sciencedaily.com/releases/2011/09/110901112537.htm | laysource = Science Daily | pmc=3195644}}</ref> Conversely, lower levels of ubiquilin-1 in the brain were associated with increased malformation of APP.<ref name="pmid21852239"/>
| summary_text = This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: UBQLN1 ubiquilin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29979| accessdate = }}</ref>
 
}}
==Similarity to Other Proteins==
 
Human UBQLN1 shares a high degree of similarity with related ubiquilins including [[UBQLN2]] and [[UBQLN4]].<ref name="pmid24674348">{{cite journal | author = Marín I | title = The ubiquilin gene family: evolutionary patterns and functional insights | journal = BMC Evol Biol | volume = 14| pages = 63 | date=March 2014 | pmid = 24674348 | doi = 10.1186/1471-2148-14-63 | pmc=4230246}}</ref>
 
==Interactions==
 
UBQLN1 has been shown to [[Protein-protein interaction|interact]] with
 
* [[HERPUD1]],<ref name="pmid18307982">{{cite journal | vauthors = Kim TY, Kim E, Yoon SK, Yoon JB | title = Herp enhances ER-associated protein degradation by recruiting ubiquilins | journal = Biochem. Biophys. Res. Commun. | volume = 369 | issue = 2 | pages = 741–6 |date=May 2008 | pmid = 18307982 | doi = 10.1016/j.bbrc.2008.02.086 }}</ref>
* [[Mammalian target of rapamycin|MTOR]],<ref name="pmid11853878">{{cite journal | vauthors = Wu S, Mikhailov A, Kallo-Hosein H, Hara K, Yonezawa K, Avruch J | title = Characterization of ubiquilin 1, an mTOR-interacting protein | journal = Biochim. Biophys. Acta | volume = 1542 | issue = 1–3 | pages = 41–56 |date=January 2002 | pmid = 11853878 | doi = 10.1016/S0167-4889(01)00164-1 }}</ref>
* [[P4HB]],<ref name="pmid12095988">{{cite journal | vauthors = Ko HS, Uehara T, Nomura Y | title = Role of ubiquilin associated with protein-disulfide isomerase in the endoplasmic reticulum in stress-induced apoptotic cell death | journal = J. Biol. Chem. | volume = 277 | issue = 38 | pages = 35386–92 |date=September 2002 | pmid = 12095988 | doi = 10.1074/jbc.M203412200 }}</ref>
* [[PSEN1]]<ref name="pmid11076969">{{cite journal | vauthors = Mah AL, Perry G, Smith MA, Monteiro MJ | title = Identification of Ubiquilin, a Novel Presenilin Interactor That Increases Presenilin Protein Accumulation | journal = J. Cell Biol. | volume = 151 | issue = 4 | pages = 847–62 |date=November 2000 | pmid = 11076969 | pmc = 2169435 | doi = 10.1083/jcb.151.4.847 }}</ref>
* [[PSEN2]],<ref name=pmid11076969/> and
* [[UBE3A]].<ref name="pmid10983987">{{cite journal | vauthors = Kleijnen MF, Shih AH, Zhou P, Kumar S, Soccio RE, Kedersha NL, Gill G, Howley PM | title = The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome | journal = Mol. Cell | volume = 6 | issue = 2 | pages = 409–19 |date=August 2000 | pmid = 10983987 | doi = 10.1016/S1097-2765(00)00040-X }}</ref>
* [[TMCO6]],<ref>{{cite journal | pmid = 25416956 | doi=10.1016/j.cell.2014.10.050 | pmc=4266588 | volume=159 | title=A proteome-scale map of the human interactome network | year=2014 | journal=Cell | pages=1212–26 | vauthors=Rolland T, Taşan M, Charloteaux B, Pevzner SJ, Zhong Q, Sahni N, Yi S, Lemmens I, Fontanillo C, Mosca R, Kamburov A, Ghiassian SD, Yang X, Ghamsari L, Balcha D, Begg BE, Braun P, Brehme M, Broly MP, Carvunis AR, Convery-Zupan D, Corominas R, Coulombe-Huntington J, Dann E, Dreze M, Dricot A, Fan C, Franzosa E, Gebreab F, Gutierrez BJ, Hardy MF, Jin M, Kang S, Kiros R, Lin GN, Luck K, MacWilliams A, Menche J, Murray RR, Palagi A, Poulin MM, Rambout X, Rasla J, Reichert P, Romero V, Ruyssinck E, Sahalie JM, Scholz A, Shah AA, Sharma A, Shen Y, Spirohn K, Tam S, Tejeda AO, Trigg SA, Twizere JC, Vega K, Walsh J, Cusick ME, Xia Y, Barabási AL, Iakoucheva LM, Aloy P, De Las RJ, Tavernier J, Calderwood MA, Hill DE, Hao T, Roth FP, Vidal M}}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal   |vauthors=Ozaki T, Kondo K, Nakamura Y, etal |title=Interaction of DA41, a DAN-binding protein, with the epidermal growth factor-like protein, S(1-5) |journal=Biochem. Biophys. Res. Commun. |volume=237 |issue= 2 |pages= 245–50 |year= 1997 |pmid= 9268694 |doi= 10.1006/bbrc.1997.7122 }}
| citations =
*{{cite journal   |vauthors=Ozaki T, Hanaoka E, Naka M, etal |title=Cloning and characterization of rat BAT3 cDNA |journal=DNA Cell Biol. |volume=18 |issue= 6 |pages= 503–12 |year= 1999 |pmid= 10390159 |doi= 10.1089/104454999315222 }}
*{{cite journal | author=Ozaki T, Kondo K, Nakamura Y, ''et al.'' |title=Interaction of DA41, a DAN-binding protein, with the epidermal growth factor-like protein, S(1-5). |journal=Biochem. Biophys. Res. Commun. |volume=237 |issue= 2 |pages= 245-50 |year= 1997 |pmid= 9268694 |doi= 10.1006/bbrc.1997.7122 }}
*{{cite journal  | vauthors=Wu AL, Wang J, Zheleznyak A, Brown EJ |title=Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane |journal=Mol. Cell |volume=4 |issue= 4 |pages= 619–25 |year= 1999 |pmid= 10549293 |doi=10.1016/S1097-2765(00)80212-9  }}
*{{cite journal | author=Ozaki T, Hishiki T, Toyama Y, ''et al.'' |title=Identification of a new cellular protein that can interact specifically with DAN. |journal=DNA Cell Biol. |volume=16 |issue= 8 |pages= 985-91 |year= 1997 |pmid= 9303440 |doi= }}
*{{cite journal   |vauthors=Kleijnen MF, Shih AH, Zhou P, etal |title=The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome |journal=Mol. Cell |volume=6 |issue= 2 |pages= 409–19 |year= 2000 |pmid= 10983987 |doi=10.1016/S1097-2765(00)00040-X }}
*{{cite journal  | author=Ozaki T, Hanaoka E, Naka M, ''et al.'' |title=Cloning and characterization of rat BAT3 cDNA. |journal=DNA Cell Biol. |volume=18 |issue= 6 |pages= 503-12 |year= 1999 |pmid= 10390159 |doi= 10.1089/104454999315222 }}
*{{cite journal  | vauthors=Mah AL, Perry G, Smith MA, Monteiro MJ |title=Identification of Ubiquilin, a Novel Presenilin Interactor That Increases Presenilin Protein Accumulation |journal=J. Cell Biol. |volume=151 |issue= 4 |pages= 847–62 |year= 2000 |pmid= 11076969 |doi=10.1083/jcb.151.4.847  | pmc=2169435 }}
*{{cite journal | author=Wu AL, Wang J, Zheleznyak A, Brown EJ |title=Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane. |journal=Mol. Cell |volume=4 |issue= 4 |pages= 619-25 |year= 1999 |pmid= 10549293 |doi=  }}
*{{cite journal   |vauthors=Wiemann S, Weil B, Wellenreuther R, etal |title=Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R | pmc=311072 }}
*{{cite journal  | author=Hanaoka E, Ozaki T, Ohira M, ''et al.'' |title=Molecular cloning and expression analysis of the human DA41 gene and its mapping to chromosome 9q21.2-q21.3. |journal=J. Hum. Genet. |volume=45 |issue= 3 |pages= 188-91 |year= 2000 |pmid= 10807547 |doi=  }}
*{{cite journal   |vauthors=Simpson JC, Wellenreuther R, Poustka A, etal |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058  | pmc=1083732 }}
*{{cite journal | author=Kleijnen MF, Shih AH, Zhou P, ''et al.'' |title=The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome. |journal=Mol. Cell |volume=6 |issue= 2 |pages= 409-19 |year= 2000 |pmid= 10983987 |doi=  }}
*{{cite journal   |vauthors=Bedford FK, Kittler JT, Muller E, etal |title=GABA(A) receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1 |journal=Nat. Neurosci. |volume=4 |issue= 9 |pages= 908–16 |year= 2001 |pmid= 11528422 |doi= 10.1038/nn0901-908 }}
*{{cite journal | author=Mah AL, Perry G, Smith MA, Monteiro MJ |title=Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation. |journal=J. Cell Biol. |volume=151 |issue= 4 |pages= 847-62 |year= 2000 |pmid= 11076969 |doi= }}
*{{cite journal   |vauthors=Wu S, Mikhailov A, Kallo-Hosein H, etal |title=Characterization of ubiquilin 1, an mTOR-interacting protein |journal=Biochim. Biophys. Acta |volume=1542 |issue= 1–3 |pages= 41–56 |year= 2002 |pmid= 11853878 |doi=10.1016/S0167-4889(01)00164-1  }}
*{{cite journal | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
*{{cite journal  | vauthors=Ko HS, Uehara T, Nomura Y |title=Role of ubiquilin associated with protein-disulfide isomerase in the endoplasmic reticulum in stress-induced apoptotic cell death |journal=J. Biol. Chem. |volume=277 |issue= 38 |pages= 35386–92 |year= 2002 |pmid= 12095988 |doi= 10.1074/jbc.M203412200 }}
*{{cite journal | author=Simpson JC, Wellenreuther R, Poustka A, ''et al.'' |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287-92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Bedford FK, Kittler JT, Muller E, ''et al.'' |title=GABA(A) receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1. |journal=Nat. Neurosci. |volume=4 |issue= 9 |pages= 908-16 |year= 2001 |pmid= 11528422 |doi= 10.1038/nn0901-908 }}
*{{cite journal   |vauthors=Gao L, Tu H, Shi ST, etal |title=Interaction with a Ubiquitin-Like Protein Enhances the Ubiquitination and Degradation of Hepatitis C Virus RNA-Dependent RNA Polymerase |journal=J. Virol. |volume=77 |issue= 7 |pages= 4149–59 |year= 2003 |pmid= 12634373 |doi=10.1128/JVI.77.7.4149-4159.2003  | pmc=150629  }}
*{{cite journal | author=Wu S, Mikhailov A, Kallo-Hosein H, ''et al.'' |title=Characterization of ubiquilin 1, an mTOR-interacting protein. |journal=Biochim. Biophys. Acta |volume=1542 |issue= 1-3 |pages= 41-56 |year= 2002 |pmid= 11853878 |doi=  }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ko HS, Uehara T, Nomura Y |title=Role of ubiquilin associated with protein-disulfide isomerase in the endoplasmic reticulum in stress-induced apoptotic cell death. |journal=J. Biol. Chem. |volume=277 |issue= 38 |pages= 35386-92 |year= 2002 |pmid= 12095988 |doi= 10.1074/jbc.M203412200 }}
*{{cite journal   |vauthors=Massey LK, Mah AL, Ford DL, etal |title=Overexpression of ubiquilin decreases ubiquitination and degradation of presenilin proteins |journal=J. Alzheimers Dis. |volume=6 |issue= 1 |pages= 79–92 |year= 2004 |pmid= 15004330 |doi=  }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Colland F, Jacq X, Trouplin V, etal |title=Functional Proteomics Mapping of a Human Signaling Pathway |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104  | pmc=442148 }}
*{{cite journal | author=Gao L, Tu H, Shi ST, ''et al.'' |title=Interaction with a ubiquitin-like protein enhances the ubiquitination and degradation of hepatitis C virus RNA-dependent RNA polymerase. |journal=J. Virol. |volume=77 |issue= 7 |pages= 4149-59 |year= 2003 |pmid= 12634373 |doi=  }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Persson P, Stockhausen MT, Påhlman S, Axelson H |title=Ubiquilin-1 is a novel HASH-1-complexing protein that regulates levels of neuronal bHLH transcription factors in human neuroblastoma cells |journal=Int. J. Oncol. |volume=25 |issue= 5 |pages= 1213–21 |year= 2005 |pmid= 15492808 |doi= 10.3892/ijo.25.5.1213}}
*{{cite journal | author=Massey LK, Mah AL, Ford DL, ''et al.'' |title=Overexpression of ubiquilin decreases ubiquitination and degradation of presenilin proteins. |journal=J. Alzheimers Dis. |volume=6 |issue= 1 |pages= 79-92 |year= 2004 |pmid= 15004330 |doi= }}
*{{cite journal   |vauthors=Bertram L, Hiltunen M, Parkinson M, etal |title=Family-based association between Alzheimer's disease and variants in UBQLN1 |journal=N. Engl. J. Med. |volume=352 |issue= 9 |pages= 884–94 |year= 2005 |pmid= 15745979 |doi= 10.1056/NEJMoa042765 }}
*{{cite journal  | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Persson P, Stockhausen MT, Påhlman S, Axelson H |title=Ubiquilin-1 is a novel HASH-1-complexing protein that regulates levels of neuronal bHLH transcription factors in human neuroblastoma cells. |journal=Int. J. Oncol. |volume=25 |issue= 5 |pages= 1213-21 |year= 2005 |pmid= 15492808 |doi=  }}
*{{cite journal | author=Bertram L, Hiltunen M, Parkinson M, ''et al.'' |title=Family-based association between Alzheimer's disease and variants in UBQLN1. |journal=N. Engl. J. Med. |volume=352 |issue= 9 |pages= 884-94 |year= 2005 |pmid= 15745979 |doi= 10.1056/NEJMoa042765 }}
}}
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Latest revision as of 07:43, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ubiquilin-1 is a protein that in humans is encoded by the UBQLN1 gene.[1][2][3]

Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to effect in vivo protein degradation.

Possible Role In Preventing Alzheimers Disease

Ubiquilin has also been shown to modulate accumulation of presenilin proteins, and is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene.[3]

Higher levels of ubiquilin-1 in the brain decreased malformation of the APP molecule which plays a key role in triggering Alzheimers disease.[4] Conversely, lower levels of ubiquilin-1 in the brain were associated with increased malformation of APP.[4]

Similarity to Other Proteins

Human UBQLN1 shares a high degree of similarity with related ubiquilins including UBQLN2 and UBQLN4.[5]

Interactions

UBQLN1 has been shown to interact with

References

  1. ↑ Ozaki T, Hishiki T, Toyama Y, Yuasa S, Nakagawara A, Sakiyama S (Oct 1997). "Identification of a new cellular protein that can interact specifically with DAN". DNA Cell Biol. 16 (8): 985–91. doi:10.1089/dna.1997.16.985. PMID 9303440.
  2. ↑ Hanaoka E, Ozaki T, Ohira M, Nakamura Y, Suzuki M, Takahashi E, Moriya H, Nakagawara A, Sakiyama S (Jul 2000). "Molecular cloning and expression analysis of the human DA41 gene and its mapping to chromosome 9q21.2-q21.3". J Hum Genet. 45 (3): 188–91. doi:10.1007/s100380050209. PMID 10807547.
  3. ↑ 3.0 3.1 "Entrez Gene: UBQLN1 ubiquilin 1".
  4. ↑ 4.0 4.1 Stieren ES, El Ayadi A, Xiao Y, Siller E, Landsverk ML, Oberhauser AF, Barral JM, Boehning D (August 2011). "Ubiquilin-1 Is a Molecular Chaperone for the Amyloid Precursor Protein". J Biol Chem. 286 (41): 35689–98. doi:10.1074/jbc.M111.243147. PMC 3195644. PMID 21852239. Lay summary – Science Daily.
  5. ↑ Marín I (March 2014). "The ubiquilin gene family: evolutionary patterns and functional insights". BMC Evol Biol. 14: 63. doi:10.1186/1471-2148-14-63. PMC 4230246. PMID 24674348.
  6. ↑ Kim TY, Kim E, Yoon SK, Yoon JB (May 2008). "Herp enhances ER-associated protein degradation by recruiting ubiquilins". Biochem. Biophys. Res. Commun. 369 (2): 741–6. doi:10.1016/j.bbrc.2008.02.086. PMID 18307982.
  7. ↑ Wu S, Mikhailov A, Kallo-Hosein H, Hara K, Yonezawa K, Avruch J (January 2002). "Characterization of ubiquilin 1, an mTOR-interacting protein". Biochim. Biophys. Acta. 1542 (1–3): 41–56. doi:10.1016/S0167-4889(01)00164-1. PMID 11853878.
  8. ↑ Ko HS, Uehara T, Nomura Y (September 2002). "Role of ubiquilin associated with protein-disulfide isomerase in the endoplasmic reticulum in stress-induced apoptotic cell death". J. Biol. Chem. 277 (38): 35386–92. doi:10.1074/jbc.M203412200. PMID 12095988.
  9. ↑ 9.0 9.1 Mah AL, Perry G, Smith MA, Monteiro MJ (November 2000). "Identification of Ubiquilin, a Novel Presenilin Interactor That Increases Presenilin Protein Accumulation". J. Cell Biol. 151 (4): 847–62. doi:10.1083/jcb.151.4.847. PMC 2169435. PMID 11076969.
  10. ↑ Kleijnen MF, Shih AH, Zhou P, Kumar S, Soccio RE, Kedersha NL, Gill G, Howley PM (August 2000). "The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome". Mol. Cell. 6 (2): 409–19. doi:10.1016/S1097-2765(00)00040-X. PMID 10983987.
  11. ↑ Rolland T, Taşan M, Charloteaux B, Pevzner SJ, Zhong Q, Sahni N, Yi S, Lemmens I, Fontanillo C, Mosca R, Kamburov A, Ghiassian SD, Yang X, Ghamsari L, Balcha D, Begg BE, Braun P, Brehme M, Broly MP, Carvunis AR, Convery-Zupan D, Corominas R, Coulombe-Huntington J, Dann E, Dreze M, Dricot A, Fan C, Franzosa E, Gebreab F, Gutierrez BJ, Hardy MF, Jin M, Kang S, Kiros R, Lin GN, Luck K, MacWilliams A, Menche J, Murray RR, Palagi A, Poulin MM, Rambout X, Rasla J, Reichert P, Romero V, Ruyssinck E, Sahalie JM, Scholz A, Shah AA, Sharma A, Shen Y, Spirohn K, Tam S, Tejeda AO, Trigg SA, Twizere JC, Vega K, Walsh J, Cusick ME, Xia Y, Barabási AL, Iakoucheva LM, Aloy P, De Las RJ, Tavernier J, Calderwood MA, Hill DE, Hao T, Roth FP, Vidal M (2014). "A proteome-scale map of the human interactome network". Cell. 159: 1212–26. doi:10.1016/j.cell.2014.10.050. PMC 4266588. PMID 25416956.

Further reading

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